SH2 Domain-Containing Protein Tyrosine Phosphatases

A subcategory of protein tyrosine phosphatases that contain SH2 type SRC HOMOLOGY DOMAINS. Many of the proteins in this class are recruited to specific cellular targets such as a cell surface receptor complexes via their SH2 domain.

Also Known As:

SH2 Domain-Containing Protein Tyrosine Phosphatase; SH2 Domain-Containing Protein-Tyrosine-Phosphatases; Src Homology-2 (SH2) Domain-Containing Phosphatase; Src Homology-2 (SH2) Domain-Containing Phosphatases; Domain-Containing Protein-Tyrosine-Phosphatases, SH2; Protein-Tyrosine-Phosphatases, SH2 Domain-Containing; SH2 Domain Containing Protein Tyrosine Phosphatase; SH2 Domain Containing Protein Tyrosine Phosphatases

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bocchinfuso, Gianfranco: 2 articles (01/2021 - 01/2017)
2.	Flex, Elisabetta: 2 articles (01/2021 - 01/2017)
3.	Martinelli, Simone: 2 articles (01/2021 - 01/2017)
4.	Pannone, Luca: 2 articles (01/2021 - 01/2017)
5.	Tartaglia, Marco: 2 articles (01/2021 - 01/2017)
6.	Chen, Lydia: 1 article (05/2022)
7.	Du, Li: 1 article (05/2022)
8.	Feng, Gen-Sheng: 1 article (05/2022)
9.	Liu, Jacey J: 1 article (05/2022)
10.	Long, Yanyan: 1 article (05/2022)

Related Diseases

1.	Noonan Syndrome (Female Pseudo-Turner Syndrome) 01/01/2017 - "Germline mutations in PTPN11, the gene encoding the Src-homology 2 (SH2) domain-containing protein tyrosine phosphatase (SHP2), cause Noonan syndrome (NS), a relatively common, clinically variable, multisystem disorder. " 01/01/2021 - "Among them, Noonan syndrome (NS) and Noonan syndrome with multiple lentigines (NSML) are allelic conditions principally associated with dominant mutations in PTPN11, which encodes the nonreceptor SH2 domain-containing protein tyrosine phosphatase SHP2. " 07/31/2020 - "Both fetuses had normal karyotype; however, after additional analysis, pathogenic variants of the PTPN11 gene (encoding SH2 domain-containing protein tyrosine phosphatase) were found, previously frequently described as somatic variants in hematological malignancies in postnatal life, but not previously described with severe prenatal phenotype of Noonan syndrome. " 09/01/2018 - "Due to the involvement of SHP2 (SH2 domain-containing protein-tyrosine phosphatase) in human disease, including Noonan syndrome and cancer, several inhibitors targeting SHP2 have been developed. "
2.	Neoplasms (Cancer) 01/01/2023 - "Pharmaceutical SH2 domain-containing protein tyrosine phosphatase 2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity." 05/01/2016 - "The altered expression of SHP-1 (SH2 domain-containing protein tyrosine phosphatase) as a consequence of promoter hypermethylation or mutations has evidently been linked to cancer development. " 09/01/2018 - "Due to the involvement of SHP2 (SH2 domain-containing protein-tyrosine phosphatase) in human disease, including Noonan syndrome and cancer, several inhibitors targeting SHP2 have been developed. " 06/08/2017 - "The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 1 (SHP-1), a non-receptor protein tyrosine phosphatase, has been reported as a negative regulator of phosphorylated signal transducer and activator of transcription 3 (STAT3) and linked to tumor development. "
3.	LEOPARD Syndrome (Syndrome, LEOPARD) 01/01/2021 - "Among them, Noonan syndrome (NS) and Noonan syndrome with multiple lentigines (NSML) are allelic conditions principally associated with dominant mutations in PTPN11, which encodes the nonreceptor SH2 domain-containing protein tyrosine phosphatase SHP2. "
4.	Hematologic Neoplasms (Hematological Malignancy) 07/31/2020 - "Both fetuses had normal karyotype; however, after additional analysis, pathogenic variants of the PTPN11 gene (encoding SH2 domain-containing protein tyrosine phosphatase) were found, previously frequently described as somatic variants in hematological malignancies in postnatal life, but not previously described with severe prenatal phenotype of Noonan syndrome. "
5.	Virus Diseases (Viral Diseases) 06/01/2006 - "We have previously shown that the SH2 domain-containing protein tyrosine phosphatase SHP-1 plays a critical role in controlling virus infection in CNS glia in vivo and in vitro. "

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