Non-Receptor Type 3 Protein Tyrosine Phosphatase

A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an amino-terminal FERM domain, an intervening region containing one or more PDZ domains, and a carboxyl-terminal phosphatase domain. Expression of this phosphatase subtype has been observed in BONE MARROW; fetal LIVER; LYMPH NODES; and T LYMPHOCYTES.

Also Known As:

Networked: 12 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ma, Shao: 3 articles (01/2020 - 01/2014)
2.	Ma, Rong: 2 articles (01/2020 - 05/2015)
3.	Suresh, Padmanaban S: 2 articles (01/2019 - 01/2014)
4.	Chen, Guan: 2 articles (05/2015 - 01/2014)
5.	He, Haitao: 1 article (04/2020)
6.	Shang, Jiaqi: 1 article (04/2020)
7.	Xu, Rui: 1 article (04/2020)
8.	Yang, Qing: 1 article (04/2020)
9.	Zhang, Renwen: 1 article (04/2020)
10.	Zhang, Shu: 1 article (04/2020)

Related Diseases

1.	Glioma (Gliomas) 01/01/2016 - "In this study, we examined protein-tyrosine phosphatase H1 (PTPH1) in human gliomas. " 01/01/2019 - "Protein Tyrosine Phosphatase H1/Protein Tyrosine Phosphatase Non receptor Type 3 (PTPH1/PTPN3) is upregulated and/or mutated in glioma, ovarian, gastric, and colorectal cancers. "
2.	Ductal Carcinoma 01/01/2020 - "The objective of this study was to determine if MLNR combined with protein-tyrosine phosphatase H1 (PTPH1) pathological expression can be used to predict the prognosis of patients with breast invasive ductal carcinoma (IDC) better than one factor only. " 01/01/2020 - "Prognostic Significance of Metastatic Lymph Nodes Ratio (MLNR) Combined with Protein-Tyrosine Phosphatase H1 (PTPH1) Expression in Operable Breast Invasive Ductal Carcinoma."
3.	Neoplasms (Cancer) 01/01/2023 - "The human protein tyrosine phosphatase non-receptor type 3 (PTPN3) is a phosphatase containing a PDZ (PSD-95/Dlg/ZO-1) domain that has been found to play both tumor-suppressive and tumor-promoting roles in various cancers, despite limited knowledge of its cellular partners and signaling functions. " 01/01/2019 - "The human protein tyrosine phosphatase non-receptor type 3 (PTPN3) is a PDZ (PSD-95/Dlg/ZO-1) domain-containing phosphatase with a tumor-suppressive or a tumor-promoting role in many cancers. " 09/25/2023 - "Six candidate target genes (glypican 4; forkhead box C1; protein tyrosine phosphatase non-receptor type 3; hydroxycarboxylic acid receptor 1; major facilitator superfamily domain containing 11; and tumor-associated calcium signal transducer 2) were downregulated in the affected submandibular gland tissue. "
4.	Colorectal Neoplasms (Colorectal Cancer) 01/15/2006 - "Protein tyrosine phosphatase H1, a member of the ubiquitous protein tyrosine phosphatase (PTP) superfamily of enzymes, is an important signaling molecule, mutant forms of which have been found in human colorectal cancers. " 01/01/2019 - "Protein Tyrosine Phosphatase H1/Protein Tyrosine Phosphatase Non receptor Type 3 (PTPH1/PTPN3) is upregulated and/or mutated in glioma, ovarian, gastric, and colorectal cancers. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2014 - "Here, we tested the hypothesis that the protein-tyrosine phosphatase H1 (PTPH1) may regulate ER tyrosine phosphorylation and thereby impact breast cancer antihormone sensitivity. " 01/01/2014 - "Protein-tyrosine phosphatase H1 increases breast cancer sensitivity to antiestrogens by dephosphorylating estrogen receptor at Tyr537." 05/30/2015 - "Protein tyrosine phosphatase H1 (PTPH1) dephosphorylates the tyrosine kinase EGFR, disrupts its interaction with the nuclear receptor ER, and increases breast cancer sensitivity to small molecule tyrosine kinase inhibitors (TKIs). "

Related Drugs and Biologics

1.	Phosphoric Monoester Hydrolases (Phosphatases)
2.	Non-Receptor Type 3 Protein Tyrosine Phosphatase
3.	Glypicans
4.	Estrogen Receptor Modulators (Antiestrogen)
5.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
6.	Protein Tyrosine Phosphatases
7.	Oncogene Proteins (Oncogene Protein)
8.	Tyrosine (L-Tyrosine)
9.	Estrogen Receptors
10.	Proteins (Proteins, Gene)