|1.||Li, Jia: 9 articles (01/2015 - 10/2006)|
|2.||Tremblay, Michel L: 9 articles (11/2012 - 04/2002)|
|3.||Oh, Won Keun: 8 articles (07/2014 - 02/2006)|
|4.||Neel, Benjamin G: 8 articles (07/2013 - 06/2004)|
|5.||Ahn, Jong Seog: 8 articles (08/2009 - 02/2006)|
|6.||Zhang, Zhong-Yin: 7 articles (11/2014 - 07/2005)|
|7.||Kim, Bo Yeon: 7 articles (08/2009 - 02/2006)|
|8.||Kennedy, Brian P: 7 articles (10/2007 - 02/2002)|
|9.||Bence, Kendra K: 6 articles (12/2015 - 10/2011)|
|10.||Kahn, Barbara B: 6 articles (07/2013 - 06/2004)|
07/15/2009 - "This study was aimed to investigate the inhibitory activities of fractions and constituents isolated from Gynostemma pentaphyllum on protein tyrosine phosphatase 1B (PTP1B) since it has been proposed as a treatment therapy for type 2 diabetes and obesity. "
08/21/2015 - "Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the treatment of type 2 diabetes and obesity, so a colorimetric method has been developed in this work for PTP1B assay and screening of its inhibitors. "
06/01/2015 - "Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the treatment of type 2 diabetes and obesity. "
02/15/2015 - "Dehydroeuryspongin A (4) inhibited protein tyrosine phosphatase 1B (PTP1B), an important target enzyme for the treatment of type II diabetes and obesity, with an IC50 value of 3.58μM. "
02/01/2015 - "Deletion of protein tyrosine phosphatase 1B rescues against myocardial anomalies in high fat diet-induced obesity: Role of AMPK-dependent autophagy."
|2.||Type 2 Diabetes Mellitus (MODY)
04/24/2015 - "Compounds 1 and 5 exhibited potent inhibitory activity (11.3 and 4.7 μM, respectively) against protein tyrosine phosphatase 1B (PTP1B), which has emerged as a viable target for treatment of type 2 diabetes mellitus. "
08/01/1999 - "Marked impairment of protein tyrosine phosphatase 1B activity in adipose tissue of obese subjects with and without type 2 diabetes mellitus."
07/08/2011 - "Novel protein tyrosine phosphatase 1B inhibitors: interaction requirements for improved intracellular efficacy in type 2 diabetes mellitus and obesity control."
01/01/2015 - "Protein tyrosine phosphatase 1B (PTP1B) is an established therapeutic target for type 2 diabetes mellitus (T2DM) and obesity. "
01/01/2013 - "Pharmacological inhibition of protein tyrosine phosphatase 1B: a promising strategy for the treatment of obesity and type 2 diabetes mellitus."
05/01/2014 - "Recently, we showed that gene deletion or pharmacological inhibition of protein tyrosine phosphatase 1B (PTP1B) improves endothelial dysfunction and reduces the severity of experimental heart failure. "
06/01/2012 - "Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B."
03/01/2009 - "Moreover, new approaches have been recently developed to specifically target the endothelial NO production, for example via inhibition of protein tyrosine phosphatase 1B, that may ultimately lead to new treatment of heart failure based on endothelial protection."
|5.||AIDS-Related Complex (ARC)
04/01/2014 - "SIRT1 improved leptin sensitivity in hypothalamic neurons in vitro and in vivo by downregulating protein-tyrosine phosphatase 1B, T cell protein-tyrosine phosphatase and suppressor of cytokine signalling 3. However, these phenotypes were absent in mice consuming a high-fat, high-sucrose diet due to decreases in ARC SIRT1 protein and hypothalamic NAD(+) levels. "
|2.||Non-Receptor Type 2 Protein Tyrosine Phosphatase
|9.||Protein-Tyrosine Kinases (Tyrosine Kinase)