Group VI Phospholipases A2

A calcium-independent phospholipase A2 group that may play a role in membrane phospholipid remodeling and homeostasis by controling the levels of PHOSPHATIDYLCHOLINE in mammalian cell membranes.

Also Known As:

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Alhans, Ruby: 1 article (12/2021)
2.	Chaudhari, Pradip: 1 article (12/2021)
3.	Dhotre, Ranjeeta: 1 article (12/2021)
4.	Dugge, Rucha: 1 article (12/2021)
5.	Gardi, Nilesh: 1 article (12/2021)
6.	Gera, Poonam: 1 article (12/2021)
7.	Gupta, Neha: 1 article (12/2021)
8.	Kowtal, Pradnya: 1 article (12/2021)
9.	Mohanty, Bhabani: 1 article (12/2021)
10.	Pansare, Kshama: 1 article (12/2021)

Related Diseases

1.	Insulinoma 05/14/1999 - "Studies of the role of group VI phospholipase A2 in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells."
2.	Neuroaxonal Dystrophies (Neuroaxonal Dystrophy, Late Infantile) 07/01/2006 - "We mapped a locus for infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation (NBIA) to chromosome 22q12-q13 and identified mutations in PLA2G6, encoding a calcium-independent group VI phospholipase A2, in NBIA, INAD and the related Karak syndrome. "
3.	Hypertrophy 01/01/2023 - "Based on our transcriptome experiment results as well as literature reports, we selected glycerophospholipid metabolizing enzymes group VI phospholipase A2 (PLA2G6) and diacylglycerol kinase ζ (DGK-ζ) as targets to further explore the potential mechanism through which momordicine I inhibited ISO-induced cardiomyocyte hypertrophy. "
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/30/2021 - "Aspirin Inhibition of Group VI Phospholipase A2 Induces Synthetic Lethality in AAM Pathway Down-Regulated Gingivobuccal Squamous Carcinoma."
5.	Karak Syndrome 07/01/2006 - "We mapped a locus for infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation (NBIA) to chromosome 22q12-q13 and identified mutations in PLA2G6, encoding a calcium-independent group VI phospholipase A2, in NBIA, INAD and the related Karak syndrome. "

Related Drugs and Biologics

1.	Arachidonic Acid (Vitamin F)
2.	Phospholipids (Phosphatides)
3.	Lysophosphatidylcholines (Lysophosphatidylcholine)
4.	Fatty Acids (Saturated Fatty Acids)
5.	Secretagogues
6.	Glycerophospholipids (Phosphoglycerides)
7.	Diacylglycerol Kinase
8.	Enzymes
9.	Calcium
10.	Aspirin (Acetylsalicylic Acid)