|1.||Hatfield, Dolph L: 9 articles (01/2015 - 05/2006)|
|2.||Carlson, Bradley A: 9 articles (01/2015 - 05/2006)|
|3.||Gladyshev, Vadim N: 9 articles (01/2015 - 05/2006)|
|4.||Yoo, Min-Hyuk: 8 articles (01/2015 - 05/2006)|
|5.||Naranjo-Suarez, Salvador: 3 articles (01/2015 - 01/2012)|
|6.||Tsuji, Petra A: 3 articles (01/2015 - 01/2012)|
|7.||Xu, Xue-Ming: 3 articles (01/2015 - 05/2006)|
|8.||Tobe, Ryuta: 3 articles (01/2015 - 08/2012)|
|9.||Björnstedt, Mikael: 3 articles (05/2012 - 02/2007)|
|10.||Moos, Philip J: 3 articles (01/2011 - 12/2009)|
|1.||Parkinson Disease (Parkinson's Disease)
12/15/2013 - "These experimental findings suggest that the expression of thioredoxin reductase 1 in the substantia nigra pars compacta of Parkinson's disease mice is significantly decreased, and that the enzyme may be associated with disease onset. "
12/15/2013 - "Because neurons are susceptible to oxidative damage and thioredoxin reductase 1 is extensively distributed in the central nervous system and has antioxidant properties, we speculated that the enzyme may be involved in the pathogenesis of Parkinson's disease. "
12/15/2013 - "Downregulation of thioredoxin reductase 1 expression in the substantia nigra pars compacta of Parkinson's disease mice."
12/15/2013 - "Real-time reverse transcription-PCR, western blot analysis and colorimetric assay showed that the levels of thioredoxin reductase 1 mRNA and protein were decreased, along with a significant reduction in thioredoxin reductase activity, in the midbrain of Parkinson's disease mice compared with normal mice. "
|2.||Movement Disorders (Movement Disorder)
03/01/2012 - "Concentrations in excess of 300 μM corresponded to dose dependent loss of cell viability which was associated with enhanced production of H(2)O(2) concomitant to elevation of gene expression for diverse antioxidant enzymes; biliverdin reductase, arsenite inducible RNA associated protein, dithiolethione-inducible gene-1 (DIG-1) and thioredoxin reductase 1. Moreover, Mn initiated significant reduction of gene expression of mitochondrial glutaryl-coenzyme A dehydrogenase (GCDH), an enzyme involved with glutaric acidemia, oxidative stress, lipid peroxidation and striatal degeneration observed in association with severe dystonic-dyskinetic movement disorder. "
|3.||Duodenal Ulcer (Curling's Ulcer)
01/01/2014 - "DSW, which contains selenium, provides intestinal protection against duodenal ulcers through the upregulation of Bcl-2 and thioredoxin reductase 1. "
01/01/2014 - "Deep-sea water containing selenium provides intestinal protection against duodenal ulcers through the upregulation of Bcl-2 and thioredoxin reductase 1."
|4.||Breast Neoplasms (Breast Cancer)
01/01/2010 - "The purpose of this work was to study the prognostic influence in breast cancer of thioredoxin reductase 1 (TXNRD1) and thioredoxin interacting protein (TXNIP), key players in oxidative stress control that are currently evaluated as possible therapeutic targets. "
01/01/2010 - "Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer."
03/09/2005 - "In this study, we have shown that three isothiocyanates, sulforaphane, erucin, and iberin, are potent inducers of thioredoxin reductase 1 (TrxR1) in human breast cancer MCF-7 cells. "
02/01/2015 - "Studies performed in a variety of human primary tumors have shown that thioredoxin reductase 1 (TrxR1) is overexpressed in tumoral tissues compared with corresponding normal tissues. "
09/21/2014 - "The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity."
03/01/2012 - "Mammalian thioredoxin reductase 1 (TrxR1) is considered to be an important anticancer drug target and to be involved in both carcinogenesis and cancer progression. "
11/15/2010 - "Trx1 and thioredoxin reductase 1 (Txnrd1) are upregulated in numerous cancers, and Txnrd1 has been reported to be indispensable for tumorigenesis. "
01/01/2010 - "Thioredoxin reductase 1 (TR1) is a major antioxidant and redox regulator in mammalian cells and appears to function as a double-edged sword in that it has roles in preventing and promoting/sustaining cancer. "
|1.||Messenger RNA (mRNA)
|6.||RNA (Ribonucleic Acid)