Phospholipases A2 (Phospholipase A2)

10/18/1990 - "Inhibitors of phospholipase A2 might therefore act to reduce the effects of inflammation, so structural information about the binding of phospholipase A2 to its substrates could be helpful in the design of therapeutic drugs. "
01/01/2017 - "The goal of present study was to elucidate the pathophysiological roles of lysosomal phospholipase A2 (LPLA2) in intraocular pressure (IOP) levels and ocular inflammation. "
01/01/2023 - "Due to the involvement of phospholipase A2 (PLA2) in inflammatory pathways, explant tissues were treated with IL-1β to mimic inflammation observed in OA. "
01/01/2023 - "Furthermore, membrane DHA can be released by phospholipase A2 and act as a substrate for the synthesis of bioactive metabolites that regulate synaptogenesis, neurogenesis, inflammation, and oxidative stress. "
03/01/2018 - "To evaluate the effect of phospholipase A2 (PLA2) inhibitors on inflammation in a genetic UC mouse model. "

11/01/1986 - "Potential therapeutic efficacy of inhibitors of human phospholipase A2 in septic shock."
01/01/1999 - "The study aims at elucidating the mechanism involved in the cell dysfunction or impairment and the protective effects of phospholipase A2 (PLA2) inhibitors in endotoxin shock. "
11/01/1991 - "A predictive model for the clearance of soluble phospholipase A2 during septic shock."
01/01/1992 - "Massive elevations of serum phospholipase A2 activity have been documented in patients with septic shock. "
11/01/1991 - "Circulating phospholipase A2 (PLA2) has been recognized as a mediator of cardiovascular collapse in septic shock. "

10/01/2007 - "85-kDa cytosolic phospholipase A2 group IValpha gene promoter polymorphisms in patients with severe asthma: a gene expression and case-control study."
01/01/2013 - "The involvement of phospholipases A2 in asthma and chronic obstructive pulmonary disease."
12/01/2015 - "We investigated whether bee venom phospholipase A2 (bvPLA2) exerts protective effects that are mediated via Tregs in OVA-induced asthma model. "
02/01/2019 - "[Association of cytoplasmic phospholipase A2 gene polymorphism with bronchial asthma and response to montelukast in children]."
01/01/2008 - "Plasma phospholipase A2 activity in patients with asthma: association with body mass index and cholesterol concentration."

11/01/2008 - "Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease."
03/01/2011 - "Phospholipases A2 and neural membrane dynamics: implications for Alzheimer's disease."
12/01/2010 - "Differential roles of phospholipases A2 in neuronal death and neurogenesis: implications for Alzheimer disease."
12/01/2009 - "Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease."
01/01/2009 - "Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease."

01/01/1995 - "Phospholipase A2 activity of peripheral-blood mononuclear leukocytes in psoriasis."
02/01/1994 - "We report for the first time the detection of transcripts of nonpancreatic phospholipase A2 (npPLA2, type II) and cytosolic (c) PLA2 in human skin, and overexpression of npPLA2 in involved skin from patients with psoriasis (plaque psoriasis and pustular psoriasis). "
02/01/1994 - "This implies that a phospholipase A2 (PLA2) may be involved in the pathogenesis of psoriasis. "
09/01/1990 - "Phospholipase A2 (PL-A2) has been known to be activated in either affected or un-affected skin of patients with psoriasis vulgaris. "
09/01/1990 - "[Phospholipase A2 activating factor in sera of patients with psoriasis vulgaris]."