Phospholipases A1 (Phospholipase A1)

A phospholipase that hydrolyzes the acyl group attached to the 1-position of PHOSPHOGLYCERIDES.

Also Known As:

Phospholipase A1; Phosphatidate 1-Acylhydrolase; 1-Acylhydrolase, Phosphatidate; Phosphatidate 1 Acylhydrolase; Lecithinase A1

Networked: 55 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Carboxylic Ester Hydrolases: 62
        Phospholipases: 2589
        Phospholipases A: 58
        Phospholipases A1: 55
        outer membrane phospholipase A: 2
        allergen Dol M I
        Arabidopsis DAD1 protein
        Drosophila PAPLA1 protein
        human LIPI protein
        human PLA1A protein
        mouse Pla1a protein
        rat Pla1a protein
        S cerevisiae Yor022c protein
        Vespa affinis vespapase

Experts

1.	Aoki, Junken: 7 articles (09/2021 - 03/2015)
2.	Kurano, Makoto: 7 articles (02/2021 - 01/2017)
3.	Yatomi, Yutaka: 7 articles (02/2021 - 01/2017)
4.	Igarashi, Koji: 5 articles (01/2021 - 01/2017)
5.	Kano, Kuniyuki: 3 articles (09/2021 - 01/2017)
6.	Shimamoto, Satoshi: 3 articles (01/2021 - 05/2018)
7.	Ikeda, Hitoshi: 3 articles (01/2020 - 01/2017)
8.	Kim, Woo-Jin: 2 articles (03/2022 - 01/2020)
9.	Lee, Si Hyeock: 2 articles (03/2022 - 01/2020)
10.	Yoon, Kyungjae Andrew: 2 articles (03/2022 - 01/2020)

Related Diseases

1.	Hypersensitivity (Allergy) 10/01/2021 - "To evaluate the frequency of phospholipase A1 in Polistes venom allergy (Pol d 1) and its diagnostic role in vespid allergy. " 01/01/2019 - "Insect venom phospholipases A1 and A2: Roles in the envenoming process and allergy." 04/01/2010 - "Recombinant phospholipase A1 (Ves v 1) from yellow jacket venom for improved diagnosis of hymenoptera venom hypersensitivity." 01/01/2020 - "Phospholipase A1 from Thai banded tiger wasp (Vespa affinis) venom also known as Ves a 1 plays an essential role in fatal vespid allergy. "
2.	Neoplasms (Cancer) 07/01/2014 - "In addition, impaired tumor cell differentiation due to the loss of RARRES3 phospholipase A1/A2 activity also contributes to lung metastasis. " 01/01/2022 - "Several studies have reported that phosphatidylserine-specific phospholipase A1 (PLA1A) might be involved in the pathogenesis of cancers. " 07/10/2015 - "Phospholipase A/acyltransferase (PLA/AT)-3 (also known as H-rev107 or AdPLA) was originally isolated as a tumor suppressor and was later shown to have phospholipase A1/A2 activity. " 03/01/2015 - "Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis."
3.	Melanoma (Melanoma, Malignant) 05/01/2018 - "Association between serum autotaxin or phosphatidylserine-specific phospholipase A1 levels and melanoma." 02/01/2021 - "Recent studies revealed that lysophospholipids (LPLs) and related molecules, such as autotaxin (ATX) and phosphatidylserine-specific phospholipase A1 (PS-PLA1 ), are candidates for novel biomarkers in melanoma, glaucoma and diabetic nephropathy. "
4.	Glaucoma 02/01/2021 - "Recent studies revealed that lysophospholipids (LPLs) and related molecules, such as autotaxin (ATX) and phosphatidylserine-specific phospholipase A1 (PS-PLA1 ), are candidates for novel biomarkers in melanoma, glaucoma and diabetic nephropathy. "
5.	Diabetic Retinopathy (Retinopathy, Diabetic) 12/11/2014 - "This study was conducted to measure the levels of PA, LPA, LPA-producing enzymes phospholipase A1/A2 (PLA1A/PLA2, respectively) and acylgylycerol kinase (AGK), the S1P receptor S1PR1, the S1P catabolising enzyme S1P lyase (SPL) and 5-lipoxygenase in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR). "

Related Drugs and Biologics

1.	Venoms
2.	Arthropod Venoms
3.	Phosphatidylserines
4.	Enzymes
5.	Biomarkers (Surrogate Marker)
6.	Phosphotransferases (Kinase)
7.	Lysophospholipids
8.	Lyases
9.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
10.	Sphingosine-1-Phosphate Receptors

Related Therapies and Procedures

1.	Organ Transplantation
2.	Oral Administration