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rho-Associated Kinases

A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
Also Known As:
ROCK Protein Kinases; ROCK-I Protein Kinase; ROCK-II Protein Kinase; ROK Kinase; p160 rhoA-Binding Kinase ROKalpha; p160ROCK; rho-Associated Coiled-Coil Containing Protein Kinase 1; rho-Associated Coiled-Coil Containing Protein Kinase 2; rho-Associated Coiled-Coil Kinase; rho-Associated Kinase 1; rho-Associated Kinase 2; rho-Associated Kinase alpha; rho-Associated Kinase beta; rho-Associated Protein Kinase alpha; rho-Associated Protein Kinase beta; rho-Kinase; Coiled-Coil Kinase, rho-Associated; Protein Kinases, ROCK; ROCK I Protein Kinase; ROCK II Protein Kinase; p160 rhoA Binding Kinase ROKalpha; rho Associated Coiled Coil Containing Protein Kinase 1; rho Associated Coiled Coil Containing Protein Kinase 2; rho Associated Coiled Coil Kinase; rho Associated Kinase; rho Associated Kinase 1; rho Associated Kinase 2; rho Associated Kinase alpha; rho Associated Kinase beta; rho Associated Kinases; rho Associated Protein Kinase alpha; rho Associated Protein Kinase beta; rho Kinase; rho-Associated Kinase
Networked: 1279 relevant articles (71 outcomes, 207 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Shimokawa, Hiroaki: 69 articles (10/2015 - 02/2002)
2. Liao, James K: 31 articles (10/2015 - 07/2002)
3. Kaibuchi, Kozo: 23 articles (09/2010 - 02/2002)
4. Fukumoto, Yoshihiro: 19 articles (06/2014 - 01/2004)
5. Takeshita, Akira: 19 articles (03/2007 - 02/2002)
6. Li, Tao: 16 articles (05/2015 - 06/2006)
7. Noma, Kensuke: 14 articles (10/2015 - 05/2003)
8. Webb, R Clinton: 14 articles (06/2013 - 12/2002)
9. Liu, Liangming: 13 articles (05/2015 - 06/2005)
10. Shimokawa, H: 13 articles (10/2007 - 01/2000)

Related Diseases

1. Pulmonary Hypertension (Ayerza Syndrome)
2. Fibrosis (Cirrhosis)
3. Hypertension (High Blood Pressure)
4. Inflammation
5. Cardiovascular Diseases (Cardiovascular Disease)

Related Drugs and Biologics

1. fasudil (AT 877)
2. Y 27632
3. Monocrotaline
4. GTP Phosphohydrolases (GTPases)
5. hydroxyfasudil
6. Angiotensin II
7. Phosphotransferases (Kinase)
8. Glucose (Dextrose)
9. Calcium
10. Nitric Oxide (Nitrogen Monoxide)

Related Therapies and Procedures

1. Oral Administration
2. Ligation
3. Stents
4. Airway Management
5. Stem Cell Transplantation