|1.||Tschöp, Matthias H: 8 articles (01/2014 - 03/2008)|
|2.||Hellström, P M: 6 articles (06/2013 - 01/2009)|
|3.||Ghigo, Ezio: 6 articles (01/2013 - 02/2002)|
|4.||Holst, Birgitte: 6 articles (01/2010 - 11/2003)|
|5.||Zigman, Jeffrey M: 5 articles (01/2015 - 12/2005)|
|6.||Culler, Michael D: 5 articles (01/2015 - 01/2005)|
|7.||Perez-Tilve, Diego: 5 articles (01/2014 - 03/2008)|
|8.||Ejskjaer, N: 5 articles (11/2013 - 06/2009)|
|9.||Wang, Ping: 5 articles (01/2010 - 09/2004)|
|10.||Wu, Rongqian: 5 articles (01/2010 - 09/2004)|
01/01/2015 - "Overexpression of GHS-R1a receptor was identified in cells of different types of tumors (e.g. "
03/01/2008 - "GHS-R1a protein was absent in the majority of adrenal tumors. "
12/01/2007 - "Our results showed that ghrelin receptor was expressed in cancers throughout the gastrointestinal tract, mainly in the cytoplasm of mucosal layer cells. "
01/01/2005 - "Downregulation ofGHS-R1a in adrenal tumors and the presence of high levels of GHS-R1b transcripts in adrenocortical tissue suggest a role for these receptors in adrenal function and growth. "
01/01/2005 - "At variance, GHS-R1b was overexpressed in both benign and malignant adrenocortical tumors. "
01/01/2010 - "(1) To compare ghrelin receptor expression between clinically stable CF subjects with normal BMI, CF subjects with cachexia and healthy controls. "
11/01/2015 - "Mechanisms of anorexia-cachexia syndrome and rational for treatment with selective ghrelin receptor agonist."
12/01/2014 - "Anamorelin HCl (ANAM) is a novel, orally active, ghrelin receptor agonist in clinical development for the treatment of cancer cachexia. "
04/01/2014 - "Anamorelin hydrochloride is an orally active ghrelin receptor agonist in development by Helsinn, for the treatment of non-small-cell lung cancer (NSCLC) cachexia. "
11/01/2001 - "Future studies are necessary to investigate putative mechanisms of ghrelin resistance such as a possible impairment of intracellular ghrelin receptor signaling in pathophysiological states presenting with cachexia."
03/01/2008 - "Mice deficient for either Ghr or its receptor (the growth hormone secretagogue receptor, GHS-R1a) seem to exhibit enhanced protection against high-fat diet-induced obesity but do not show a substantial metabolic phenotype on a standard diet. "
01/01/2010 - "It is suggested that inverse agonist and antagonist against the ghrelin receptor provide an interesting possibility in the development of drugs for treatment of obesity and diabetes and that improved structural understanding of the receptor function facilitates the drug development."
01/01/2010 - "Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity."
03/01/2006 - "By combination of the observations from this study with those related to the phenotype of subjects carrying another natural ghrelin receptor mutation, Phe279Leu, having identical molecular-pharmacological properties, it is proposed that selective lack of ghrelin receptor constitutive signaling leads to a syndrome characterized not only by short stature, but also by obesity that apparently develops during puberty."
01/01/2005 - "No evidence of relationship between ghrelin receptor gene polymorphisms and body mass regulation was found, however, until now there is no study on relationships between these polymorphisms and metabolic complications of obesity. "
09/01/2004 - "Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis."
11/01/2005 - "Plasma levels of ghrelin, a newly-identified endogenous ligand for growth hormone secretagogue receptor and a potent vasodilatory peptide, are significantly reduced in sepsis. "
01/01/2010 - "Recently we have shown that ghrelin, a stomach-derived peptide which is an endogenous ligand for the growth hormone secretagogue receptor (GHSR-1a), is beneficial in attenuating the inflammatory response, organ injury and mortality in an experimental model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). "
08/01/2009 - "Ghrelin treatment, mediated through ghrelin receptors in the brain, attenuates sepsis-induced inflammation and mortality. "
08/01/2009 - "Ghrelin reduces serum HMGB1 levels and ameliorates gut barrier dysfunction in sepsis by vagus nerve activation via central ghrelin receptors. "
05/01/2015 - "Learning more about the properties of neurons in the spinal defecation center and the roles of ghrelin receptors in the defecation reflex will accelerate the development of improved treatments of constipation. "
05/01/2015 - "A ghrelin receptor agonist is an effective colokinetic in rats with diet-induced constipation."
01/01/2009 - "Oral administration of ghrelin receptor agonists that enter the central nervous system could possibly be used to relieve acute cases of constipation or to clear the bowel for colonoscopy."
12/01/2015 - "It has been recently demonstrated that the ghrelin receptor agonist, HM01, caused defecation in rats that were treated to provide a model for the constipation of Parkinson's disease. "
05/01/2015 - "Recent publications indicate that the activation of the ghrelin receptors in the spinal cord can alleviate constipation due to dietary causes, Parkinsonism, and SCI in rodents. "
|5.||HMGB1 Protein (HMG1)
|9.||Growth Hormone (Somatotropin)
|1.||Drug Therapy (Chemotherapy)
|5.||Gastric Bypass (Roux-en-Y Gastric Bypass)