|1.||Kangawa, Kenji: 130 articles (09/2015 - 01/2002)|
|2.||Hosoda, Hiroshi: 62 articles (11/2014 - 01/2002)|
|3.||Nakazato, Masamitsu: 51 articles (09/2015 - 01/2002)|
|4.||Inui, Akio: 37 articles (09/2015 - 05/2003)|
|5.||Ghigo, Ezio: 33 articles (11/2015 - 03/2002)|
|6.||Cummings, David E: 30 articles (04/2014 - 05/2002)|
|7.||Kojima, Masayasu: 29 articles (09/2015 - 02/2002)|
|8.||Aydin, Suleyman: 28 articles (10/2015 - 01/2007)|
|9.||Tschöp, Matthias H: 28 articles (01/2014 - 01/2003)|
|10.||Akamizu, Takashi: 26 articles (01/2014 - 09/2002)|
|1.||Weight Loss (Weight Reduction)
03/01/2014 - "Duodenal-jejunal bypass liner implantation provokes rapid weight loss and improved glycemic control, accompanied by elevated fasting ghrelin levels."
11/01/2002 - "We have tested this hypothesis in individuals with widely varying body mass and fat distribution and evaluated whether the improved GH concentrations on weight loss are associated with enhanced ghrelin levels. "
05/01/2011 - "Future directions for investigating relationships between ghrelin and behavioural factors, examining the efficacy of behavioural programmes in reducing ghrelin and improving weight loss maintenance are discussed."
08/01/2007 - "Collectively, these results suggest that in patients with metabolic syndrome, improved adiposity signaling and increased postprandial CCK concentrations may act together as a possible compensatory control mechanism to maintain low intakes and facilitate weight loss, despite an increase in fasting ghrelin concentrations and subjective measures of hunger."
03/01/2006 - "Weight loss is associated with an improved postprandial plasma ghrelin response to a carbohydrate meal, whereas the response to a fat meal is not modified."
12/01/2015 - "The synergy of ghrelin agonists and physical exercise could be beneficial in conditions where muscle wasting is present, such as that found in patients with advanced cancer. "
09/01/2015 - "In this study, we examined the effects of ghrelin on cancer promotion in vivo using murine intestinal carcinogenesis models. "
01/01/2013 - "Moreover, in vitro studies showed the capability of ghrelin to modulate tumor cell functions such as cell proliferation, apoptosis and invasiveness, although with variable and even paradoxical effects in different cell models. "
12/01/2012 - "Further studies using in vivo models are required to determine whether ghrelin has a role in cancer progression."
12/01/2012 - "Some single nucleotide polymorphisms in the ghrelin and GHSR genes have shown associations with cancer risk; however, larger studies are required. "
01/01/2011 - "Ghrelin is a very promising treatment option for cardiac cachexia, with the analogue BIM-28131 (RM-131) being the most effective compound."
09/18/2001 - "Chronic subcutaneous administration of ghrelin improved LV dysfunction and attenuated the development of LV remodeling and cardiac cachexia in rats with CHF."
05/01/2014 - "Several studies indicate that ghrelin administration is a valid treatment for cachexia because it improves muscle mass and function, likely by restoring a positive energy balance. "
01/01/2013 - "These effects of ghrelin have been confirmed in multiple types of cachexia in both laboratory and human studies, suggesting a positive future for cachexia treatments."
01/01/2013 - "In this chapter, we review the mechanisms of action of ghrelin and present the available data in animal models and human trials using ghrelin or ghrelin mimetics in different settings of cachexia."
10/09/2008 - "Loss of ghrelin signaling is protective against diet-induced obesity, suggesting that ghrelin plays a significant homeostatic role in conditions of metabolic stress. "
01/01/2013 - "The main goal of this study was to develop a safe and effective anti-ghrelin vaccine for obesity, through the chemical conjugation of ghrelin with a virus like particle, namely NS1 protein tubules from the Bluetongue Virus (BTV) using a hetero-bifunctional cross linker. "
01/01/2012 - "As it appears to play a role in diet-induced obesity, blocking the action of ghrelin is likely to be effective for treating and preventing obesity. "
01/01/2013 - "The discovery of GOAT helped to redefine the ghrelin research field and enabled the development of another target molecule for potential therapies aimed to prevent/treat diabetes and obesity."
01/01/2005 - "Additionally, the efficacy of different treatment strategies against obesity seems to be related to modifications in plasma ghrelin levels. "
|5.||Body Weight (Weight, Body)
12/01/2013 - "The percent excess body weight loss was significantly greater in the high-ghrelin group, without differences in the patient backgrounds between the two groups (p = 0.015). "
11/01/2012 - "Significant reduction of body weight and level of serum ghrelin can be achieved with minimal morbidity by LSG or LMGBP in patients with PWS."
09/18/2001 - "CHF rats treated with ghrelin, however, showed a significantly greater increase in body weight than those given placebo (+10% versus +3%, P<0.05). "
10/01/2013 - "Ghrelin, a 28 amino acid peptide, is effective in control of appetite and body weight. "
01/01/2015 - "At the same time, the ghrelin agonist improved spatial learning in the mice, raised their activity levels, and reduced their body weight and fat mass. "
|7.||Glucagon-Like Peptide 1 (GLP 1)
|8.||Insulin-Like Growth Factor I (IGF-1)
|3.||Renal Dialysis (Hemodialysis)
|5.||Gastric Bypass (Roux-en-Y Gastric Bypass)