BCR-ABL Negative Atypical Chronic Myeloid Leukemia (Leukemia, Myeloid, Philadelphia Negative)

16  relevant articles (0 outcomes, 1 trials/studies) found for this Disease

Leukemia, Myeloid, Philadelphia Negative; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Leukemia, Myelogenous, Ph1 Negative; Leukemia, Myelogenous, Ph1-Negative; Leukemia, Myeloid, Chronic, Atypical; Leukemia, Myeloid, Ph1 Negative; Leukemia, Myeloid, Ph1-Negative; Myelogenous Leukemia, Ph1-Negative; Myeloid Leukemia, Ph1-Negative; aCML; Leukemia, Ph1-Negative Myelogenous; Leukemia, Ph1-Negative Myeloid; Leukemia, Philadelphia-Negative Myeloid; Leukemias, Ph1-Negative Myelogenous; Leukemias, Ph1-Negative Myeloid; Leukemias, Philadelphia-Negative Myeloid; Myelogenous Leukemia, Ph1 Negative; Myelogenous Leukemias, Ph1-Negative; Myeloid Leukemia, Ph1 Negative; Myeloid Leukemia, Philadelphia Negative; Myeloid Leukemias, Ph1-Negative; Myeloid Leukemias, Philadelphia-Negative; Ph1-Negative Myelogenous Leukemia; Ph1-Negative Myelogenous Leukemias; Ph1-Negative Myeloid Leukemia; Ph1-Negative Myeloid Leukemias; Philadelphia-Negative Myeloid Leukemia; Philadelphia-Negative Myeloid Leukemias; aCMLs; Atypical Chronic Myeloid Leukemia; Chronic Myeloid Leukemia, Atypical; Leukemia, Myeloid, Philadelphia-Negative; Myeloid Leukemia, Philadelphia-Negative

Disease Context: Research Results

Related Diseases

1.	BCR-ABL Negative Atypical Chronic Myeloid Leukemia (Leukemia, Myeloid, Philadelphia Negative)
2.	Chromosome Aberrations (Chromosome Abnormalities)
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
4.	Hematologic Neoplasms (Hematological Malignancy)
5.	Hypereosinophilic Syndrome (Loeffler Endocarditis)

Experts

1.	Grand, Francis H: 1 article (11/2007)
2.	Iqbal, Sameena: 1 article (11/2007)
3.	Cross, Nicholas C P: 1 article (11/2007)
4.	Zhang, Lingyan: 1 article (11/2007)
5.	Russell, Nigel H: 1 article (11/2007)
6.	Chase, Andrew: 1 article (11/2007)
7.	Elmaagacli, A H: 1 article (12/2004)
8.	Ottinger, H: 1 article (12/2004)
9.	Koldehoff, M: 1 article (12/2004)
10.	Peceny, R: 1 article (12/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to BCR-ABL Negative Atypical Chronic Myeloid Leukemia:

1.	Antigen Receptors (Antigen Receptor)IBA 03/01/1991 - "Further studies are indicated to ascertain whether antigen receptor gene rearrangement constitutes a molecular marker useful in the diagnosis of aCML." 03/01/1991 - "Cross-lineage rearrangement of antigen receptor genes in atypical chronic myeloid leukemia." Order ALL the reference details at left...
2.	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 05/01/2004 - "We report a case of BCR-ABL-negative atypical chronic myeloid leukemia (CML) with translocation t(4;22) (q12;q11.2) juxtaposing the breakpoint cluster region (BCR) and platelet-derived growth factor receptor-alpha (PDGFRA) genes" 05/01/2004 - "Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia." 06/15/2001 - "H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22)." 10/01/2003 - "Imatinib mesylate elicits positive clinical response in atypical chronic myeloid leukemia involving the platelet-derived growth factor receptor beta." Order ALL the reference details at left...
3.	imatinib (Gleevec)FDA Link 10/15/2004 - "We conclude that TP53BP1-PDGFRB is a novel imatinib target in atypical chronic myeloid leukemia." 06/01/2003 - "Forty-eight patients with AML (n = 10), MDS (n = 8), myelofibrosis (n = 18), atypical chronic myeloid leukemia (CML; n = 7), chronic myelomonocytic leukemia (CMML; n = 3), or polycythemia vera (n = 2) were treated with imatinib 400 mg daily" 10/01/2003 - "Imatinib mesylate elicits positive clinical response in atypical chronic myeloid leukemia involving the platelet-derived growth factor receptor beta." Order ALL the reference details at left...
4.	Pyridinolcarbamate (P23)IBA 11/01/2002 - "To our knowledge, this is the first published case of aCML in which the chromosomal abnormality t(9;22)(p23;ql 1) was detected." 11/01/2002 - "Translocation t(9;22) (p23;q11) in atypical chronic myeloid leukemia (aCML) presenting osteolytic lesions." 04/01/2005 - "We have identified a t(8;9)(p21-23;p23-24) in seven male patients (mean age 50, range 32-74) with diverse hematologic malignancies and clinical outcomes: atypical chronic myeloid leukemia/chronic eosinophilic leukemia (n = 5), secondary acute myeloid leukemia (n = 1), and pre-B-cell acute lymphoblastic leukemia (n = 1)" Order ALL the reference details at left...
5.	T-Cell Antigen Receptors (T-Cell Receptor)IBA 03/01/1991 - "The configuration of immunoglobulin (Ig) and T-cell receptor (TCR) genes was investigated in a case of atypical chronic myeloid leukemia (aCML) lacking a cytogenetically detectable Philadelphia chromosome and molecular evidence of breakpoint cluster region (bcr) rearrangement as determined by 5' and 3' bcr gene probes" Order ALL the reference details at left...
6.	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/01/2007 - "CONCLUSION: Although FLT3 abnormalities are uncommon in aCML, SPTBN1-FLT3 is a novel constitutively active tyrosine kinase that appears to responsive to both targeted signal transduction therapy and immunotherapy." 11/01/2007 - "A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy." Order ALL the reference details at left...
7.	Petroleum (Crude Oil)IBA 04/01/1999 - "We report a new chromosomal reciprocal translocation t(5;10)(q33;q22) in a 49-year-old man with atypical chronic myeloid leukemia (a-CML) and history of occupational exposure to petroleum products including benzene and other hydrocarbons" Order ALL the reference details at left...
8.	OligosaccharidesIBA 11/11/1991 - "Structure of the capsular polysaccharide and the O-side-chain of the lipopolysaccharide from Acetobacter methanolicus MB 58/4 (IMET 10945), and of oligosaccharides resulting from their degradation by the bacteriophage Acml." Order ALL the reference details at left...
9.	Immunoglobulins (Immunoglobulin)IBA 03/01/1991 - "The configuration of immunoglobulin (Ig) and T-cell receptor (TCR) genes was investigated in a case of atypical chronic myeloid leukemia (aCML) lacking a cytogenetically detectable Philadelphia chromosome and molecular evidence of breakpoint cluster region (bcr) rearrangement as determined by 5' and 3' bcr gene probes" Order ALL the reference details at left...
10.	Immunoglobulin G (IgG)IBA 02/01/1999 - "Atypical chronic myeloid leukemia presenting with trilineage dysplasia and IgG (lambda) type monoclonal gammopathy]" Order ALL the reference details at left...

Therapies and Procedures

1.	Hematopoietic Stem Cell Transplantation 12/01/2004 - "We evaluated the outcome of aCML after allogeneic hematopoietic stem cell transplantation (HSCT)" 12/01/2004 - "Outcome of hematopoietic stem cell transplantation in patients with atypical chronic myeloid leukemia." Order ALL the reference details at left...
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/01/1993 - "A 17-year-old woman was admitted for bone marrow transplantation with the diagnosis of atypical Philadelphia-negative chronic myelogenous leukemia (aCML), cytogenetically characterized by trisomy 8 as the sole chromosome aberration" Order ALL the reference details at left...
3.	Isogeneic Transplantation 12/01/2004 - "Our findings suggest that the outcome of allogeneic or syngeneic transplantation in patients with aCML may not be worse than the outcome of transplantation for BCR-ABL-positive CML." Order ALL the reference details at left...
4.	Transplantation (Transplant Recipients) 12/01/2004 - "Our findings suggest that the outcome of allogeneic or syngeneic transplantation in patients with aCML may not be worse than the outcome of transplantation for BCR-ABL-positive CML." Order ALL the reference details at left...
5.	Immunotherapy 11/01/2007 - "CONCLUSION: Although FLT3 abnormalities are uncommon in aCML, SPTBN1-FLT3 is a novel constitutively active tyrosine kinase that appears to responsive to both targeted signal transduction therapy and immunotherapy." 11/01/2007 - "A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy." Order ALL the reference details at left...