Chemokine CXCL6

A CXC chemokine that has stimulatory and chemotactic activities towards NEUTROPHILS. It has specificity for CXCR1 RECEPTORS and CXCR2 RECEPTORS.

Also Known As:

Chemokine (C-X-C Motif) Ligand 6; Chemokine alpha 3; Granulocyte Chemotactic Protein-2; Small Inducible Cytokine B6; CXCL6, Chemokine; Chemokine, CXCL6; Chemotactic Protein-2, Granulocyte; Granulocyte Chemotactic Protein 2; CXCL6 Chemokine

Networked: 32 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Van Damme, Jo: 3 articles (12/2007 - 01/2004)
2.	Opdenakker, Ghislain: 2 articles (12/2007 - 01/2004)
3.	Put, Willy: 2 articles (12/2007 - 04/2007)
4.	Struyf, Sofie: 2 articles (12/2007 - 04/2007)
5.	Cao, Lei: 1 article (08/2021)
6.	Chen, Juan: 1 article (08/2021)
7.	Li, Xiangping: 1 article (08/2021)
8.	Li, Yueqin: 1 article (08/2021)
9.	Liu, Zhaoqian: 1 article (08/2021)
10.	Mei, Jie: 1 article (08/2021)

Related Diseases

1.	Inflammation (Inflammations) 08/01/2009 - "Previous studies have shown that granulocyte chemotactic protein 2 is up-regulated during mucosal inflammation (e.g. " 12/01/2003 - "GADD45, Bax, SAS, and granulocyte chemotactic protein-2 were overexpressed exclusively following solar-simulated radiation, whereas tape stripping led to the modulation of genes implicated in different pathways (inflammation, cell proliferation, cell differentiation, detoxification, etc.). " 08/01/2009 - "Nevertheless, unlike interleukin-8, a role of granulocyte chemotactic protein 2 in gingival inflammation has not been yet demonstrated. " 07/01/2008 - "Granulocyte chemotactic protein 2 (GCP-2)/CXCL6 is a CXC chemokine expressed by macrophages and epithelial and mesenchymal cells during inflammation. " 11/01/2000 - "We have previously shown that members of the ELR(+) CXC chemokine family, including IL-8; growth-related oncogenes alpha, beta, and gamma; granulocyte chemotactic protein 2; and epithelial neutrophil-activating protein-78, can mediate angiogenesis in the absence of preceding inflammation. "
2.	Periodontitis 08/01/2009 - "In this study we aimed to evaluate the expression of the chemokine granulocyte chemotactic protein 2 in clinically healthy vs. diseased gingival tissues and to explore possible correlations with clinical and microbiological markers of periodontitis. " 08/01/2009 - "The level of expression of granulocyte chemotactic protein 2 correlates with the severity of periodontitis and appears to act as a hitherto unrecognized functional adjunct to interleukin-8 in diseased gingival tissues."
3.	Necrosis 01/01/2010 - "The aim of the present study was to examine the mRNA expression of factors that have been suggested to be involved in both events in the bovine endometrial epithelium, namely bovine granulocyte chemotactic protein 2 (CXCL5), interleukin-1 beta (IL1B), IL6, IL8, tumour necrosis factor (TNF), cyclooxygenase 2 (PTGS2) and haptoglobin (HP). "
4.	Ischemia 01/01/2018 - "In present study, we produced genome-edited MSCs that secreted dual chemokine granulocyte chemotactic protein-2 (GCP-2) and stromal-derived factor-1α (SDF-1α) and determined their therapeutic potential in the context of experimental ischemia. "
5.	Neoplasms (Cancer) 10/01/2001 - "Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercurrent principle." 01/01/2021 - "In the HCC-TME, CAF-derived cardiotrophin-like cytokine factor 1 (CLCF1) increased chemokine (C-X-C motif) ligand 6 (CXCL6) and TGF-β secretion in tumor cells, which subsequently promoted tumor cell stemness in an autocrine manner and TAN infiltration and polarization in a paracrine manner. " 10/01/2001 - "Although intratumoral injection of granulocyte chemotactic protein-2 (GCP-2) had no effect on tumor parameters, needle-free stable expression of the chemokine resulted in enhanced tumor growth. " 03/27/1998 - "Natural forms of the C-X-C chemokine granulocyte chemotactic protein-2 (GCP-2) and the C-C chemokine regulated on activation normal T cell expressed and secreted (RANTES), which miss two NH2-terminal residues, including a Pro in the penultimate position, have been isolated from leukocytes or tumor cells. " 09/01/2004 - "The overexpressions of several genes including CD36, putative lymphocyte G0/G1 switch gene (G0S2), tumor protein D52-like 1 (TPD52L1), chemokine (C-X-C motif) ligand 6, myxovirus resistant gene 1 (MX1), and the down-regulation of the immunoglobulin superfamily containing leucine-rich repeat (ISLR), neurotrimin, insulin-like growth factor 2 associated protein (IGF2A), and apoptosis-related RNA binding protein (NAPOR3) were newly identified. "

Related Drugs and Biologics

1.	Chemokines
2.	Interleukin-8 (Interleukin 8)
3.	Interleukin-1beta (Interleukin 1 beta)
4.	Cyclooxygenase 2 (Cyclooxygenase-2)
5.	Interleukin-6 (Interleukin 6)
6.	Messenger RNA (mRNA)
7.	Haptoglobins
8.	CXC Chemokines
9.	Cytokines
10.	Proteins (Proteins, Gene)