Chemokine CCL21

A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.

Also Known As:

6Ckine; Exodus-2 Chemokine; SLC Chemokine; Secondary Lymphoid-Tissue Chemokine; Thymus-Derived Chemotactic Agent 4; CCL21, Chemokine; Chemokine, CCL21; Chemokine, Exodus-2; Chemokine, SLC; Chemokine, Secondary Lymphoid-Tissue; Exodus 2 Chemokine; Lymphoid-Tissue Chemokine, Secondary; Secondary Lymphoid Tissue Chemokine; Thymus Derived Chemotactic Agent 4; CCL21 Chemokine

Networked: 108 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sharma, Sherven: 4 articles (01/2013 - 04/2004)
2.	Matsushima, K: 4 articles (08/2007 - 04/2000)
3.	Lipp, Martin: 3 articles (01/2014 - 09/2006)
4.	Hillinger, Sven: 3 articles (01/2013 - 04/2004)
5.	Huang, Min: 3 articles (01/2013 - 04/2004)
6.	Dubinett, Steven M: 3 articles (05/2011 - 04/2004)
7.	Wu, Jian: 3 articles (12/2008 - 11/2007)
8.	Broxmeyer, Hal E: 2 articles (01/2021 - 08/2002)
9.	Hromas, Robert: 2 articles (01/2021 - 08/2002)
10.	Zhang, Yong: 2 articles (10/2019 - 07/2013)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 01/01/2001 - "Melanoma-conditioned DC exhibited an increased adhesion capacity to a melanoma cell line in vitro and did not migrate in response to SLC chemokine. " 01/01/2007 - "Here, we report that intratumoral expression of the chemokine CCL21 enhances the efficacy of adoptive T-cell therapy in a mouse model of melanoma. " 05/13/2015 - "The presence of lymph node (LN)-like vasculature in tumours, characterized by expression of peripheral node addressin and chemokine CCL21, is correlated with T-cell infiltration and positive prognosis in breast cancer and melanoma patients. " 04/01/2004 - "CCL21 chemokine regulates chemokine receptor CCR7 bearing malignant melanoma cells." 08/01/2006 - "The antitumor efficacy of human melanoma-associated antigen (hgp100) and chemokine CCL21 in combination with interleukin-12 (IL-12) was evaluated in a syngeneic melanoma mouse model. "
2.	Neoplasms (Cancer) 06/01/2007 - "Previous studies have shown that secondary lymphoid chemokine, CCL21, can be used for modulation of tumor-specific immune responses. " 08/01/2023 - "The chemokine CCL21 regulates immune and cancer cell migration through its receptor CCR7. " 06/15/2023 - "CCL21, a secondary lymphoid tissue chemokine, plays an important role in generating an effective anti-tumor immune response. " 04/29/2014 - "The secondary lymphoid tissue chemokine (CCL21) is closely associated with lymphoid homing and anti-tumor immune responses. " 03/01/2011 - "In agreement with recent reports, expression of the chemokine CCL21 is enhanced after MG/MP activation and correlates with tumor growth. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/03/2011 - "Based on our preclinical findings, we are assessing the efficacy of intratumoral injection of dendritic cells (DC) transduced with an adenoviral vector expressing the secondary lymphoid chemokine (CCL21) gene (Ad-CCL21-DC) in a phase I trial in advanced non-small cell lung cancer (NSCLC). " 12/01/2018 - "When combined with the CCL21 chemokine, which recruits T cells and enhances T-cell responses, additive effects have been demonstrated in non-small cell lung cancer mouse models. "
4.	Infections 07/01/2011 - "Injury, infection and autoimmune triggers increase CNS expression of the chemokine CCL21. " 01/01/2008 - "The migration of Rv and S7 infected MoDC towards secondary lymphoid chemokine (CCL21) was 50% lower after 1 day of infection compared to LPS stimulation. " 11/01/2007 - "Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections." 03/01/2006 - "MCMV infection caused a specific, but transient transcriptional suppression of secondary lymphoid chemokine (CCL21). " 01/15/2015 - "Previous studies proposed that reduced T cell responses during coinfections are due to diminished recruitment of naive T cells through infection-induced decreases in chemokine CCL21. "
5.	Carcinoma (Carcinomatosis) 03/15/2006 - "The antitumor efficiency of dendritic cells transduced with an adenovirus vector expressing secondary lymphoid chemokine (CCL21) was evaluated in a murine model of spontaneous bronchoalveolar cell carcinoma. " 01/01/2004 - "C26 colon carcinoma tumour cell line transduced with CCL21/SLC/6Ckine showed reduced tumorigenicity when injected in vivo into immunocompetent mice. " 08/15/2000 - "These dual properties of mouse 6Ckine/SLC were tested for the induction of an antitumor response by transducing the C26 colon carcinoma tumor cell line with a cDNA encoding mouse 6Ckine/SLC. " 05/15/2002 - "In this study, we found that 4 of 6 (67%) gastric carcinoma cell lines tested expressed functional CCR7 for the chemokine CCL21/6Ckine, as demonstrated by calcium mobilization and actin polymerization assays. " 04/01/2004 - "To establish a more efficient treatment for immunotherapy against solid tumors, we have evaluated the antitumor effect by coexpression of a chemokine CCL21/secondary lymphoid tissue chemokine and a costimulatory molecule LIGHT in colon carcinoma C26. "

Related Drugs and Biologics

1.	Antigens
2.	Interleukin-12 (IL 12)
3.	Paclitaxel (Taxol)
4.	Chemokine CCL21
5.	Vaccines
6.	A-Form DNA (A-DNA)
7.	Folic Acid (Vitamin M)
8.	Lysosomal Membrane Proteins
9.	Therapeutic Uses
10.	CD40 Ligand (CD40L)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Induction Chemotherapy
4.	Length of Stay
5.	Enema (Enemas)