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Pre-B Cell Receptors

Membrane proteins in precursor B-LYMPHOCYTES (pre-B Cells). They are composed of membrane-bound MU IMMUNOGLOBULIN HEAVY CHAINS in complex with SURROGATE LIGHT CHAINS instead of conventional IMMUNOGLOBULIN LIGHT CHAINS. Only successful rearrangement of the VDJ segments, at the Ig heavy chain gene locus (IMMUNOGLOBULIN HEAVY CHAIN GENES), will generate mu heavy chains that can pair with surrogate light chains. Thus formation of the pre-B cell receptors is an important checkpoint in the development of mature B cells.
Also Known As:
Pre-B Cell Receptor; Cell Receptor, Pre-B; Cell Receptors, Pre-B; Pre B Cell Receptor; Pre B Cell Receptors; Receptor, Pre-B Cell; Receptors, Pre-B Cell
Networked: 22 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Müschen, Markus: 9 articles (06/2015 - 03/2004)
2. Hofmann, Wolf-Karsten: 4 articles (08/2009 - 03/2004)
3. Nahar, Rahul: 3 articles (03/2015 - 08/2009)
4. Chen, Zhengshan: 3 articles (03/2015 - 08/2013)
5. Jumaa, Hassan: 3 articles (08/2009 - 06/2005)
6. Feldhahn, Niklas: 3 articles (09/2005 - 03/2004)
7. Klein, Florian: 3 articles (09/2005 - 03/2004)
8. Druker, Brian J: 2 articles (03/2015 - 11/2012)
9. Hurtz, Christian: 2 articles (03/2015 - 08/2013)
10. Melnick, Ari: 2 articles (03/2015 - 08/2013)

Related Diseases

1. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
2. Neoplasms (Cancer)
3. B-Cell Lymphoma (Lymphoma, B Cell)
4. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell)
5. Leukemia

Related Drugs and Biologics

1. Phosphotransferases (Kinase)
2. Galectin 1 (LGALS1)
3. Extracellular Matrix Proteins
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6. Laminin (Merosin)
7. Glycosaminoglycans
8. Glycoproteins (Glycoprotein)
9. Fibronectins (Fibronectin)
10. Antigens