|1.||Myers, Martin G: 21 articles (12/2014 - 05/2003)|
|2.||Kastin, Abba J: 12 articles (08/2015 - 02/2008)|
|3.||Hsuchou, Hung: 12 articles (08/2015 - 02/2008)|
|4.||Pan, Weihong: 12 articles (08/2015 - 02/2008)|
|5.||Surmacz, Eva: 9 articles (05/2015 - 03/2006)|
|6.||Chua, Streamson C: 9 articles (12/2013 - 03/2004)|
|7.||Tavernier, Jan: 8 articles (11/2015 - 12/2008)|
|8.||Otvos, Laszlo: 6 articles (05/2015 - 01/2011)|
|9.||Wu, Xiaojun: 6 articles (10/2013 - 07/2011)|
|10.||Morton, Gregory J: 6 articles (09/2013 - 05/2003)|
09/01/2014 - "Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor."
04/01/2012 - "This study investigated the efficacy of PostC in the leptin receptor-deficient db/db mice, which possess Type 2 diabetic characteristics including obesity, hyperglycaemia and hyperleptinaemia. "
10/01/2008 - "To test the efficacy of CAT in decreasing obesity and diabetes we used both a model of diet-induced obesity (DIO) and a genetic model of obesity (i.e., mice lacking the leptin receptor). "
07/01/2014 - "Previous studies suggested Leptin Receptor (LEPR) gene Polymorphisms is associated with obesity and OSAS. "
01/01/2012 - "This study evaluated the association between obesity and the K109R, Q223R, and K656N polymorphisms of the leptin receptor (LEPR) locus. "
|2.||Breast Neoplasms (Breast Cancer)
07/01/2011 - "Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer."
03/01/2011 - "The aim of this study was to investigate the relationship of the mutations of leptin receptor gene exon 4, exon 6, exon9, and exon20 with the tumorigenesis of breast cancer. "
05/01/2015 - "Recently, we have read with great interest the article entitled "The association between polymorphisms in the leptin receptor (LEPR) gene and risk of breast cancer: a systematic review and pooled analysis" published online by Wang et al. (Breast Cancer Res Treat 136:231-239, 2012). "
08/01/2014 - "Effect of leptin receptor Q223R polymorphism on breast cancer risk."
01/01/2014 - "Human primary and secondary breast cancer tissues were analysed for SK1 and leptin receptor expression using quantitative real-time polymerase chain reaction (qRT-PCR) assay. "
12/30/2011 - "In a previous study, leptin receptor-deficient wild-type mice became diabetic and suffered from fasting hyperglycemia whereas isogenic AQP9(-/-) knock-out mice remained normoglycemic. "
01/01/2016 - "In summary, downregulation of SGLT1 in an obese type 2 diabetic mouse model with hyperleptinemia is presumably mediated via the short form of the leptin receptor and reduces overt hyperglycemia. "
01/01/2012 - "When leptin receptor mutation is introgressed into the Nidd2/of congenic strain, the rat showed hyperglycemia equivalent to that of the parental OLETF rat. "
07/01/2009 - "Diabetic (db/db) mice have obese and diabetic phenotypes, including hyperglycemia, because of disruption of the leptin receptor. "
02/01/2007 - "In conclusion, 1) the FFA-induced impairment in beta-cell function is accentuated in the presence of a single copy of a mutated leptin receptor gene, independent of hyperglycemia. "
|4.||Body Weight (Weight, Body)
06/01/2009 - "Previous studies have illustrated the importance of leptin receptor (OB-Rb) mediated action on adipocytes in the regulation of body weight. "
10/01/2005 - "Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study."
10/01/2015 - "On the other, the leptin receptor antagonist Allo-aca did not alter body weight or muscle mass in treated mice compared to VEH mice. "
10/01/2014 - "Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake."
10/01/2012 - "Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract."
11/01/2013 - "In the present study we analyzed central nervous system (CNS) morphological and functional consequences of long-term insulin resistance and T2D in db/db mice (leptin receptor KO mice). "
01/01/2001 - "This study demonstrates that the ZDF rat carries a genetic defect in beta-cell transcription that is inherited independently from the leptin receptor mutation and insulin resistance. "
07/01/2011 - "Here, we demonstrate that the expression of Angptl2 in epididymal adipose tissue of C57BL/6J mice shows pulsatility and circadian rhythmicity and that the rhythmicity was disrupted in high-fat-fed and leptin receptor-deficient diabetic db/db mice with insulin resistance. "
05/01/2010 - "Plasma soluble leptin receptor (sOB-R) levels were inversely associated with diabetes risk factors, including adiposity and insulin resistance, and highly correlated with the expression levels of leptin receptor, which is ubiquitously expressed in most tissues. "
02/01/2010 - "The leptin receptor (LEPR) is associated with insulin resistance, a key feature of metabolic syndrome (MetS). "
|2.||Protein Isoforms (Isoforms)
|5.||Biological Markers (Surrogate Marker)
|7.||Gonadotropin-Releasing Hormone (GnRH)
|10.||STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
|1.||Drug Therapy (Chemotherapy)
|2.||Highly Active Antiretroviral Therapy (HAART)