|1.||Champy, Pierre: 5 articles (08/2014 - 01/2004)|
|2.||Chang, Fang-Rong: 5 articles (11/2004 - 04/2002)|
|3.||Liaw, Chih-Chuang: 5 articles (11/2004 - 04/2002)|
|4.||Wu, Yang-Chang: 5 articles (11/2004 - 04/2002)|
|5.||Tanaka, Tetsuaki: 4 articles (03/2015 - 03/2008)|
|6.||Yamori, Takao: 4 articles (03/2015 - 03/2008)|
|7.||Kojima, Naoto: 4 articles (03/2015 - 03/2008)|
|8.||Yao, Zhu-Jun: 4 articles (01/2012 - 01/2003)|
|9.||Lannuzel, Annie: 4 articles (07/2007 - 04/2002)|
|10.||Jiang, Sheng: 3 articles (01/2012 - 01/2003)|
09/04/1995 - "These results show that the Annonaceous acetogenins are an extremely potent class of compounds, and their inhibition of cell growth can be selective for cancerous cells and also effective for drug resistant cancer cells, while exhibiting only minimal toxicity to 'normal' non-cancerous cells."
01/01/2015 - "The present analysis suggests that acetogenins can act as yet another important source for obtaining promising lead compounds in order to contribute to cancer prevention, however, in future extensive in-vivo studies in animal models will be needed to provide insight for lead development. "
01/03/2003 - "Studies on mimicry of naturally occurring annonaceous acetogenins: non-THF analogues leading to remarkable selective cytotoxicity against human tumor cells."
10/01/2015 - "Graviola (botanical name: Annona Muricata) contain bioactive compound "annonaceous acetogenins" known for anticancer activity on cancer cell lines. "
01/01/2015 - "Annonaceous acetogenins was a nature compound from Uvaria accuminata and it has show the anti-tumor proliferation activity in many types cancer. "
|2.||Prostatic Neoplasms (Prostate Cancer)
06/15/2014 - "These three acetogenins demonstrated an antiproliferative against human prostate cancer PC-3 cells. "
06/01/2015 - "Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer."
09/23/2011 - "In addition, tomatoes (Lycopersicon esculentum Mill) which contains the powerful antioxidant and anti-prostate cancer agent, lycopene; cabbage (Brassica oleracea) containing indole-3-carbinol; citrus fruits containing pectin; Soursop (Annona muricata) containing annonaceous acetogenins; soya beans (Glycine max) containing isoflavones; chilli pepper (Capsicum annuum) containing capsaicin, and green tea (Camellia sinensis) containing (-) epigallocatechin gallate (EGCG), (-) epicatechin, (-) epicatechin-3-gallate and (-) epigallocatechin -3-gallate which are widely reported to posses prostate cancer chemopreventive compounds are also grown in Nigeria and other African countries. "
12/15/2011 - "Topical application of acetylenic acetogenins (AAG) from avocado (0.01-1.0mg/ear), was effective in inhibiting both 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema, and in decreasing tissue myeloperoxidase activity (indicative of polymorphonuclear leukocyte influx). "
|4.||Parkinsonian Disorders (Parkinsonism)
01/01/2009 - "Annonaceous acetogenins are proposed as environmental neurotoxicants consumed through medicinal and alimentary habits and responsible for atypical parkinsonian syndromes observed in tropical areas. "
12/01/2005 - "Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe."
08/01/2005 - "The development of atypical parkinsonism in Guadeloupe and probably elsewhere, could result from synergistic toxicity, but acetogenins are probably the most potent neurotoxin, acting as mitochondrial complex I inhibitor."
09/23/2009 - "Additionally, acetogenin compounds contained in fruit of pawpaw relatives (soursop or Annona muricata ) and tea made from the leaves of these plants may lead to an increased risk of atypical Parkinsonism later in life with overconsumption of these compounds. "
05/01/2005 - ": The overrepresentation of atypical parkinsonism on Guadeloupe and Guam could be related to the consumption of plants containing (simultaneously) isoquinoline derivates which are toxic for dopaminergic neurons and inhibitors of the mitochondrial respiratory chain such as acetogenins. "
|5.||Hepatocellular Carcinoma (Hepatoma)
01/01/2015 - "In this study, we showed that annonaceous acetogenins is correlated with the drug resistance reversal in human hepatocellular carcinoma BEL-7402/5-FU and HepG2/ADM cell lines. "
01/01/2015 - "Therefore, we demonstrate that Akt/NF-κB pathway was involved in Annonaceous acetogenins reverses drug resistance of human hepatocellular carcinoma cells. "
01/01/2015 - "Annonaceous acetogenins reverses drug resistance of human hepatocellular carcinoma BEL-7402/5-FU and HepG2/ADM cell lines."
05/01/2011 - "It has also been reported that annonaceous acetogenins affect hepatocellular carcinoma (HCC) cells in the G1 phase, leading to apoptosis. "
04/01/2002 - "These new acetogenins exhibited significant activity in in vitro cytotoxic assays against two human hepatoma cell lines, Hep G(2) and 2,2,15. "
|1.||Heterologous Transplantation (Xenotransplantation)