Acetogenins

Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. They are found in ANNONACEAE and other PLANTS. Related compounds cyclize to MACROLIDES.

Also Known As:

Networked: 106 relevant articles (7 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Champy, Pierre: 9 articles (04/2022 - 01/2004)
2.	Li, Xiang: 7 articles (02/2019 - 04/2009)
3.	Chen, Yong: 6 articles (02/2019 - 07/2012)
4.	Kojima, Naoto: 5 articles (05/2022 - 03/2008)
5.	Chang, Fang-Rong: 5 articles (11/2004 - 04/2002)
6.	Liaw, Chih-Chuang: 5 articles (11/2004 - 04/2002)
7.	Wu, Yang-Chang: 5 articles (11/2004 - 04/2002)
8.	Wang, Xiangtao: 4 articles (06/2022 - 01/2016)
9.	Chen, Jianwei: 4 articles (02/2019 - 04/2009)
10.	Tanaka, Tetsuaki: 4 articles (03/2015 - 03/2008)

Related Diseases

1.	Neoplasms (Cancer) 09/04/1995 - "These results show that the Annonaceous acetogenins are an extremely potent class of compounds, and their inhibition of cell growth can be selective for cancerous cells and also effective for drug resistant cancer cells, while exhibiting only minimal toxicity to 'normal' non-cancerous cells." 09/01/2016 - "Annonaceous acetogenins (ACGs) nanosuspensions based on a self-assembly stabilizer and the significantly improved anti-tumor efficacy." 12/21/2016 - "Conclusively, our work demonstrates that acetogenins are effective and selective inducers of the ESR that can block NPC proliferation, and illustrate a previously unappreciated antitumor mechanism of acetogenins that is effective against nasopharyngeal malignancies." 01/01/2015 - "The present analysis suggests that acetogenins can act as yet another important source for obtaining promising lead compounds in order to contribute to cancer prevention, however, in future extensive in-vivo studies in animal models will be needed to provide insight for lead development. " 01/03/2003 - "Studies on mimicry of naturally occurring annonaceous acetogenins: non-THF analogues leading to remarkable selective cytotoxicity against human tumor cells."
2.	Prostatic Neoplasms (Prostate Cancer) 05/10/2017 - "These acetogenins demonstrated potent anti-proliferative activities against human prostate cancer PC-3 cells." 01/01/2016 - "Isolation of three new annonaceous acetogenins from Graviola fruit (Annona muricata) and their anti-proliferation on human prostate cancer cell PC-3." 06/15/2014 - "These three acetogenins demonstrated an antiproliferative against human prostate cancer PC-3 cells. " 06/01/2015 - "Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer." 03/23/2023 - "Targeting Carbohydrate Mimetics of Tetrahydrofuran-Containing Acetogenins to Prostate Cancer."
3.	Edema (Dropsy) 12/15/2011 - "Topical application of acetylenic acetogenins (AAG) from avocado (0.01-1.0mg/ear), was effective in inhibiting both 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema, and in decreasing tissue myeloperoxidase activity (indicative of polymorphonuclear leukocyte influx). "
4.	Choriocarcinoma 10/01/2021 - "Sensitive Tumor Cell Line for Annonaceous Acetogenins and High Therapeutic Efficacy at a Low Dose for Choriocarcinoma Therapy."
5.	Hepatocellular Carcinoma (Hepatoma) 02/05/2019 - "In this study, we used metabolomic method to evaluate the MDR in hepatocellular carcinoma, and investigate regulatory of annonaceous acetogenins on MDR of hepatocellular carcinoma. " 01/01/2015 - "In this study, we showed that annonaceous acetogenins is correlated with the drug resistance reversal in human hepatocellular carcinoma BEL-7402/5-FU and HepG2/ADM cell lines. " 02/05/2019 - "Non-targeted metabolomic analysis on multidrug resistance hepatocellular carcinoma cell and reversal effect of annonaceous acetogenins." 01/01/2015 - "Therefore, we demonstrate that Akt/NF-κB pathway was involved in Annonaceous acetogenins reverses drug resistance of human hepatocellular carcinoma cells." 01/01/2015 - "Annonaceous acetogenins reverses drug resistance of human hepatocellular carcinoma BEL-7402/5-FU and HepG2/ADM cell lines."

Related Drugs and Biologics

1.	Flavonoids
2.	Polyphenols
3.	Stilbenes
4.	Peroxidase (Myeloperoxidase)
5.	Carotenoids (Carotene)
6.	Neurotoxins
7.	annonacin
8.	tetrahydrofuran
9.	Proteins (Proteins, Gene)
10.	Methanol (Carbinol)

Related Therapies and Procedures

1.	Therapeutics
2.	Traditional Medicine (Folk Remedies)
3.	Drug Therapy (Chemotherapy)