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Agouti Signaling Protein

A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.
Also Known As:
ASIP Protein; Agouti Protein; Agouti Switch Protein
Networked: 54 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Leibel, Rudolph L: 3 articles (05/2011 - 11/2002)
2. Eizirik, Eduardo: 2 articles (02/2015 - 01/2012)
3. O'Brien, Stephen J: 2 articles (02/2015 - 01/2012)
4. Menotti-Raymond, Marilyn: 2 articles (02/2015 - 01/2012)
5. Barsh, Gregory S: 2 articles (02/2015 - 01/2012)
6. David, Victor A: 2 articles (02/2015 - 01/2012)
7. Schneider, Alexsandra: 2 articles (02/2015 - 01/2012)
8. Wolff, George L: 2 articles (11/2007 - 10/2005)
9. Nonogaki, Katsunori: 2 articles (05/2007 - 12/2006)
10. Oka, Yoshitomo: 2 articles (05/2007 - 12/2006)

Related Diseases

1. Melanoma (Melanoma, Malignant)
2. Neoplasms (Cancer)
3. Obesity
4. Body Weight (Weight, Body)
5. Melanosis (Freckles)

Related Drugs and Biologics

1. Melanocyte-Stimulating Hormones (MSH)
2. Ligands
3. Melanocortin Receptors (Melanocortin Receptor)
4. Type 1 Melanocortin Receptor
5. Agouti-Related Protein
6. Leptin
7. Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)
8. Monophenol Monooxygenase (Tyrosinase)
9. Messenger RNA (mRNA)
10. Hormones

Related Therapies and Procedures

1. Caloric Restriction