|1.||Leibel, Rudolph L: 3 articles (05/2011 - 11/2002)|
|2.||Eizirik, Eduardo: 2 articles (02/2015 - 01/2012)|
|3.||O'Brien, Stephen J: 2 articles (02/2015 - 01/2012)|
|4.||Menotti-Raymond, Marilyn: 2 articles (02/2015 - 01/2012)|
|5.||Barsh, Gregory S: 2 articles (02/2015 - 01/2012)|
|6.||David, Victor A: 2 articles (02/2015 - 01/2012)|
|7.||Schneider, Alexsandra: 2 articles (02/2015 - 01/2012)|
|8.||Wolff, George L: 2 articles (11/2007 - 10/2005)|
|9.||Nonogaki, Katsunori: 2 articles (05/2007 - 12/2006)|
|10.||Oka, Yoshitomo: 2 articles (05/2007 - 12/2006)|
|1.||Melanoma (Melanoma, Malignant)
11/01/1995 - "This study demonstrates that murine agouti protein causes both a time- and concentration-dependent suppression of melanogenesis in B16 F1 murine melanoma cells. "
01/01/2013 - "Agouti signaling protein (ASIP) locus on chromosome 20q11 is implicated, as shown by genome-wide association studies, in phenotype variation and melanoma risk. "
03/01/2002 - "We sought to characterize the agouti signaling protein gene (ASIP) in a group of white subjects, to assess whether ASIP was a determinant of human pigmentation and whether this gene may be associated with increased melanoma risk. "
08/01/2008 - "Gray horses carrying a loss-of-function mutation in ASIP (agouti signaling protein) had a higher incidence of melanoma, implying that increased melanocortin-1 receptor signaling promotes melanoma development in Gray horses. "
07/06/2005 - "Variants of the melanocortin-1 receptor (MC1R) gene have been associated with fair pigmentation and melanoma risk, and a polymorphism of the Agouti Signaling Protein (ASIP) gene has been associated with dark pigmentation. "
11/01/2007 - "In the present study, we ascertained whether agouti signaling protein (ASIP) levels in A(vy)/a or a/a livers are associated with hepatocyte proliferation as a possible factor in promotion of hepatocellular tumor formation. "
02/01/1996 - "Ectopic expression of the agouti protein results in enhanced susceptibility to tumor formation in tissues which are already sensitized to neoplastic transformation by their strain genome. "
05/01/1994 - "This review seeks to summarize the current state of knowledge regarding the obesity, stimulation of somatic growth, and enhancement of tumor formation caused by the A(vy) mutation, and to interpret these pleiotropic effects in terms of the normal function of the agouti protein."
01/01/2012 - "Beside its role in melanogenesis, the agouti signaling protein (ASIP) has been related to obesity. "
05/27/2011 - "The ubiquitous overexpression of agouti-signaling protein (ASP), a paracrine-signaling molecule that regulates pigment-type switching in the hair follicle of the mouse, is responsible for the obesity and yellow pelage of the Yellow mouse (A(y)). "
06/01/2007 - "Avy/agouti (Avy) mice have late onset obesity related to overexpression of agouti signaling protein (ASP) in the hypothalamus. "
09/01/2006 - "The hypomorphic allele suppresses the yellow pigmentation and obesity of the A(y) mouse that ubiquitously overexpresses agouti signaling protein (ASP). "
11/01/2002 - "The mouse coat color mutant mahoganoid (md) darkens coat color and decreases the obesity of A(y) mice that ectopically overexpress agouti-signaling protein. "
|4.||Body Weight (Weight, Body)
06/01/1999 - "The larger mean brain weight and retention, during caloric restriction, of the somewhat greater prerestriction Avy/A mean body weight compared with prerestriction A/a mice were consonant with the hypothesis that ectopic agouti protein affects somatic growth directly or indirectly. "
05/01/2007 - "Milnacipran suppressed food intake and body weight in wild-type mice and in A(y) mice, which have ectopic expression of the agouti protein. "
02/01/1998 - "Agouti protein and Agouti-related protein (Agrp) are paracrine-signaling molecules that normally regulate pigmentation and body weight, respectively. "
05/28/1999 - "Agouti protein and Agouti-related protein (Agrp) regulate pigmentation and body weight, respectively, by antagonizing melanocortin receptor signaling. "
03/11/1999 - "Agouti protein and agouti-related protein are homologous paracrine signalling molecules that normally regulate hair colour and body weight, respectively, by antagonizing signalling through melanocortin receptors. "
01/01/2012 - "We have sequenced the coding region of the Agouti Signaling Protein (ASIP) gene in multiple leopard and Asian golden cat individuals, and identified distinct mutations strongly associated with melanism in each of them. "
01/01/2009 - "We focused on two genes known to cause melanism in other taxa, Mc1r and its antagonist, the agouti signaling protein (Agouti). "
02/01/2015 - "We identify mutations of Agouti signaling protein (ASIP) or the Melanocortin 1 receptor (MC1R) as independent causes of melanism in three closely related South American species: the pampas cat (Leopardus colocolo), the kodkod (Leopardus guigna), and Geoffroy's cat (Leopardus geoffroyi). "
|1.||Melanocyte-Stimulating Hormones (MSH)
|3.||Melanocortin Receptors (Melanocortin Receptor)
|4.||Type 1 Melanocortin Receptor
|7.||Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)
|8.||Monophenol Monooxygenase (Tyrosinase)
|9.||Messenger RNA (mRNA)