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Withanolides

Ergostane derivatives of 28 carbons with oxygens at C1, C22, and C26 positions and the side chain cyclized. They are found in WITHANIA plant genus and have cytotoxic and other effects.
Networked: 81 relevant articles (7 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Cohen, Mark S: 6 articles (12/2019 - 12/2011)
2. Chang, Fang-Rong: 5 articles (11/2022 - 05/2007)
3. Kaul, Sunil C: 5 articles (10/2022 - 12/2014)
4. Wadhwa, Renu: 5 articles (10/2022 - 12/2014)
5. Gunatilaka, A A Leslie: 5 articles (01/2021 - 02/2014)
6. Subramanian, Chitra: 5 articles (12/2019 - 03/2013)
7. Kuang, Haixue: 4 articles (03/2022 - 07/2019)
8. Timmermann, Barbara N: 4 articles (12/2019 - 12/2011)
9. Wu, Yang-Chang: 4 articles (02/2019 - 05/2007)
10. Nicotra, Viviana E: 4 articles (01/2019 - 05/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Psoriasis (Pustulosis Palmaris et Plantaris)
3. Inflammation (Inflammations)
4. Melanoma (Melanoma, Malignant)
06/10/2020 - "New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells."
01/01/2018 - "We have reported for the first time that Viwithan with 5% withanolides has a potent cytotoxic effect, particularly against B16F1 murine melanoma cells among the different cancer cell lines tested. "
12/27/2011 - "Using a MTS viability assay, eight withanolides (1, 2, 3, 7, 8, 15, 16, and 19) and four acetylated derivatives (1a, 1b, 2a, and 2b) showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986), melanoma (B16F10 and SKMEL-28), and normal fetal fibroblast (MRC-5) cells with IC₅₀ values in the range between 0.067 and 9.3 μM."
01/01/2017 - "All withanolides were evaluated for their cytotoxic activity against a panel of tumor cell lines including LNCaP (androgen-sensitive human prostate adenocarcinoma), 22Rv1 (androgen-resistant human prostate adenocarcinoma), ACHN (human renal adenocarcinoma), M14 (human melanoma), SK-MEL-28 (human melanoma), and normal human foreskin fibroblast cells. "
01/01/2018 - "Interestingly, we found that Viwithan was particularly very effective against B16F1 melanoma cells with a half maximal inhibitory concentration value of 220 μg/mlThe microscopic observations following acridine orange/ethidium bromide staining and DNA fragmentation assays clearly indicated that Viwithan might initiate late apoptosis in B16F1 cellsThe binding affinity of withanolides in Viwithan with antiapoptotic proteins of B-cell lymphoma 2 family was predicted using AutoDock tool. "
5. B-Cell Lymphoma (Lymphoma, B Cell)

Related Drugs and Biologics

1. withanone
2. Proteins (Proteins, Gene)
3. Ashwagandha
4. withaferin A
5. Phytochemicals
6. Lactones
7. Imiquimod (Aldara)
8. 3- rhamnopyranosyl(1- 4)- glucopyranosyl- 12- diacetoxy- 20- hydroxywitha- 5,24- dienolide
9. Messenger RNA (mRNA)
10. Cell Surface Receptors

Related Therapies and Procedures

1. Anesthesia
2. Chemoprevention
3. Therapeutics
4. Ayurvedic Medicine (Siddha Medicine)
5. Immunotherapy