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Steroidogenic Factor 1

A transcription factor and member of the nuclear receptor family NR5 that is expressed throughout the adrenal and reproductive axes during development. It plays an important role in sexual differentiation, formation of primary steroidogenic tissues, and their functions in post-natal and adult life. It regulates the expression of key steroidogenic enzymes.
Also Known As:
AD4BP Protein; Ad4-Binding Protein; Adrenal 4 Binding Protein; FTZF1 Protein; Fushi Tarazu Factor Homolog 1; NR5A1 Protein; Nuclear Receptor 5A1 Protein; SF-1 Transcription Factor; Steroid Hormone Receptor Ad4BP; Ad4 Binding Protein; Transcription Factor, SF-1
Networked: 142 relevant articles (3 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Parker, Keith L: 9 articles (10/2009 - 01/2002)
2. Achermann, John C: 6 articles (07/2012 - 03/2007)
3. Lin, Lin: 6 articles (07/2012 - 03/2007)
4. Lalli, Enzo: 5 articles (03/2020 - 02/2005)
5. Bashamboo, Anu: 4 articles (12/2018 - 10/2010)
6. Morohashi, Ken-Ichirou: 4 articles (11/2016 - 04/2003)
7. Majdic, Gregor: 4 articles (01/2016 - 02/2002)
8. Biebermann, Heike: 4 articles (05/2014 - 01/2008)
9. Köhler, Birgit: 4 articles (05/2014 - 01/2008)
10. López, Miguel: 3 articles (10/2021 - 11/2018)

Related Diseases

1. Wilms Tumor (Wilm's Tumor)
2. Dosage-sensitive sex reversal
01/01/2020 - "Changes in AMH may be mediated by steroidogenic factor 1 (SF1), an enhancer of AMH, and dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX1), that antagonizes SF1. "
02/01/2007 - "A variety of transcription factors including Wilms tumor gene (Wt-1), steroidogenic factor 1 (Sf-1), dosage-sensitive sex reversal, adrenal hypoplasia congenita on the X-chromosome, Gene 1 (Dax-1), and pre-B-cell transcription factor 1 (Pbx1) have been defined as necessary for regular adrenocortical development. "
04/01/2015 - "Rats were killed 6 hours after the injection, and the adrenal glands were collected for measurement of steroidogenic acute regulatory protein, steroidogenic factor 1, and dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 messenger RNAs and protein using real-time quantitative polymerase chain reaction and Western immunoblotting, respectively. "
04/01/2006 - "Taking advantage of these cells, we have examined the effect of ACTH on DAX-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on X-chromosome, gene 1) and SF-1 (steroidogenic factor 1), two transcription factors known to respectively repress and activate adrenocortical steroidogenesis by acting on common target genes. "
12/01/2005 - "Differential regulation of STAR mRNA was concomitant with the presence of the stimulatory transcription factor steroidogenic factor 1, and absence of the inhibitory transcription factor dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene-1, transcripts. "
3. Obesity
4. Familial Hypoadrenocorticism
06/26/2019 - "The etiologies of the 49 cases were adrenoleukodystrophy (ALD; n = 22), X-linked adrenal hypoplasia congenital (X-AHC; n = 20), autoimmune polyglandular syndrome (APS; n = 3), triple A syndrome (n = 2), steroidogenic factor 1 (SF-1) gene mutation (n = 1) and adrenalectomy (n = 1). "
12/01/2005 - "We analyzed mRNA by slot-blot hybridization and also quantified mRNA for transcription factors necessary for adrenocortical development by quantitative real-time PCR: steroidogenic factor 1 and dosage-sensitive sex reversal, adrenal hypoplasia congenital, critical region on the X chromosome (DAX-1). "
08/01/2004 - "Placebo-treated ArKO ovaries have increased Sox9 (15-fold; P < 0.001), Müllerian-inhibiting substance (2.9-fold), Lrh-1 (7.7-fold), and dosage-sensitive sex reversal adrenal hypoplasia congenital critical region on the X chromosome gene 1 (12-fold) expression compared with Wt at 10 wk. Steroidogenic factor 1 was similar to Wt. Consistent with increased serum T levels and Leydig cells in their ovaries, placebo-treated ArKO ovaries had increased 17alpha-hydroxylase, 17beta-hydroxysteroid dehydrogenase type-3, and 17beta-hydroxysteroid dehydrogenase type-1 expression compared with Wt at 10 wk. E2 treatment for 3 wk improved the ovarian phenotype, decreased development of Sertoli cells, decreased the expression of Sox9, Lrh-1, and the steroidogenic enzymes in ArKO ovaries, and induced ovulation in some cases. "
08/01/2004 - "We measured mRNA expression of Sertoli cell, Sry-like HMG box protein 9 (Sox9); three upstream transcription factors, liver receptor homolog-1 (Lrh-1), steroidogenic factor 1, and dosage-sensitive sex reversal adrenal hypoplasia congenital critical region on the X chromosome gene 1; and one downstream factor, Müllerian-inhibiting substance. "
01/01/2001 - "Here, we consider mutations in KAL in X-linked Kallmann syndrome; DAX1 in X-linked adrenal hypoplasia congenita; the related orphan nuclear receptor, steroidogenic factor-1; leptin and prohormone convertase-1, which may influence GnRH release and processing; the GnRH receptor; the pituitary transcription factors, HESX-1, LHX3 and PROP-1; and the gonadotropins, follicle stimulating hormone (FSH) and luteinizing hormone (LH). "
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Enzymes
2. Glucose (Dextrose)
3. Insulin (Novolin)
4. Lipids
5. Protein Isoforms (Isoforms)
6. Dihydrotachysterol (AT 10)
7. 3 (or 17)-beta-hydroxysteroid dehydrogenase
8. Transcription Factors (Transcription Factor)
9. DNA (Deoxyribonucleic Acid)
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Lasers (Laser)
2. Drug Therapy (Chemotherapy)
3. Castration
4. Adrenalectomy