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Thiosugars

Sugar analogs in which the ring oxygen is replaced by a sulfur.

Also Known As:

Thio-Sugars; Thio Sugars

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Thiosugars: 6

Experts

1.	Witczak, Zbigniew J: 4 articles (01/2020 - 01/2003)
2.	Poplawski, Tomasz: 2 articles (01/2020 - 01/2017)
3.	Sarnik, Joanna: 2 articles (01/2020 - 01/2017)
4.	Bielski, Roman: 1 article (01/2020)
5.	Gajek, Arkadiusz: 1 article (01/2020)
6.	Olejniczak, Agnieszka: 1 article (01/2020)
7.	Pawelczyk, Jakub: 1 article (01/2020)
8.	Rykowski, Sebastian: 1 article (01/2020)
9.	Sliwinski, Tomasz: 1 article (01/2020)
10.	Toma, Monika: 1 article (01/2020)

Related Diseases

1.	Virus Diseases (Viral Diseases) 05/16/2017 - "The replacement of oxygen atoms in sugars with sulfur forms thio-sugars, which are potentially useful for the treatment of diabetes and some bacterial and viral infections. "
2.	Neoplasms (Cancer) 01/01/2017 - "The data indicates that thio-sugars may become drug alternatives for the cancer treatment but such undertaking needs further studies." 01/01/2020 - "(1-4)-Thiodisaccharides, thiosugars with the 1-4-thio bridge, were recently shown to induce oxidative stress, as well as, apoptosis in cancer cells in the low micromolar range; however, the detailed mechanism of their anticancer action still remains unknown. " 01/01/2017 - "Thio-sugars have been described as potent inhibitors of cancer cell growth but the detailed mechanism of action remains unknown. "
3.	Inflammation (Inflammations) 12/01/2017 - "In this paper, we have included the description of experiments in ex vivo regulation of IL-10 and synthesis of thio-sugars and poly-sugars to produce radiopharmaceuticals for monitoring inflammation. "
4.	Communicable Diseases (Infectious Diseases) 11/01/2023 - "Thio sugars are effective inhibitors of glycosylases, have considerable therapeutic potential, and are used as drugs in the treatment of diabetes and infectious diseases. "
5.	Carcinoma (Carcinomatosis) 01/02/2003 - "Concentrations of thio-sugars that decreased tumor cell line viability by 50% (IC(50)), measured via the MTT assay, ranged from 6.4 to 38.3 microg/mL. The effect of alpha-(1-->4)-3'-deoxythiodisaccharide derivatives were most profound on human pancreatic epithelial carcinoma (PANC-1) cells with compounds 8 and 9 having IC(50) values of 6.4 microg/mL and 8.2 microg/mL, respectively. "

Related Drugs and Biologics

1.	Sugars
2.	Sulfur
3.	Oxygen (Dioxygen)
4.	Radiopharmaceuticals
5.	Interleukin-10 (Interleukin 10)