Classical Lissencephalies and Subcortical Band Heterotopias

42  relevant articles (1 outcomes, 1 trials/studies) found for this Disease

Agyria-Pachygyria-Band Spectrum; Double Cortex Syndrome; Isolated Lissencephaly Sequence; Lissencephaly Syndrome, Miller-Dieker; Lissencephaly, Miller-Dieker; Subcortical Laminar Heterotopia; Type 1 Lissencephaly; X-Linked Lissencephaly; Agyria Pachygyria Band Spectrum; Band Heterotopia, Lissencephaly-Subcortical; Classical Lissencephalies; Classical Lissencephaly; Heterotopia, Lissencephaly-Subcortical Band; Heterotopia, Subcortical Laminar; Heterotopias, Lissencephaly-Subcortical Band; Heterotopias, Subcortical Band; Heterotopias, Subcortical Laminar; Lissencephalies, Type 1; Lissencephalies, X-Linked; Lissencephaly Subcortical Band Heterotopia; Lissencephaly Syndrome, Miller Dieker; Lissencephaly, Classical; Lissencephaly, Miller Dieker; Lissencephaly, X Linked; Lissencephaly-Subcortical Band Heterotopias; Miller Dieker Syndrome; Miller-Dieker Lissencephaly; Miller-Dieker Lissencephaly Syndrome; Subcortical Band Heterotopias; Syndrome, Double Cortex; Syndrome, Miller-Dieker; Syndrome, Miller-Dieker Lissencephaly; Type 1 Lissencephalies; X Linked Lissencephaly; X-Linked Lissencephalies; Heterotopia, Subcortical Band; Lissencephalies, Classical; Lissencephaly, Type 1; Lissencephaly, X-Linked; Lissencephaly-Subcortical Band Heterotopia; Miller-Dieker Syndrome; Subcortical Band Heterotopia

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Seizures (Seizure)
2.	Classical Lissencephalies and Subcortical Band Heterotopias
3.	Lissencephaly
4.	Neuronal Migration Disorders
5.	Syndrome
18 Diseases and 19 more articles analyzed in the Research Interface, order at left...

Experts

1.	Nanba, Yukiko: 1 article (09/2007)
2.	Ohno, Kousaku: 1 article (09/2007)
3.	Oka, Akira: 1 article (09/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Classical Lissencephalies and Subcortical Band Heterotopias:

1.	lamotrigine (Lamictal)FDA LinkGeneric 05/01/1999 - "In patients with subcortical laminar heterotopia, atonic and generalized tonic-clonic seizures can be substantially reduced or eliminated by corpus callosotomy or treatment with lamotrigine." 05/01/1999 - "Treatment of seizures in subcortical laminar heterotopia with corpus callosotomy and lamotrigine." Get all the results and reference details, order at left...
2.	Nonsense Codon (Nonsense Mutation)IBA 10/01/2008 - "In the present study, we investigated a subpopulation of GABAergic interneurons in the brain of an infant with XLAG, who had a novel nonsense mutation of the ARX gene, compared with those of age-matched normal controls and Miller-Dieker syndrome" Get all the results and reference details, order at left...
3.	Platelet Activating FactorIBA 04/01/2008 - "Lis1 was identified as a mutated gene in classical lissencephaly patients, and turned out to be a beta-subunit of platelet activating factor acetylhydrolase" 02/01/2001 - "The Miller-Dieker syndrome locus (LIS-1) encodes the platelet activating factor acetylhydrolase-1, beta1 subunit" 05/01/1998 - "The 45K subunit of platelet-activating factor acetylhydrolase (PAFAH-45K) is the product of a candidate gene for Miller-Dieker lissencephaly" 07/21/1994 - "Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]" 01/01/1999 - "Platelet-activating factor (PAF), a phospholipid signaling molecule found in brain, modulates several neural functions and is implicated in the human developmental brain disorder Miller-Dieker Lissencephaly (MDL)" Get all the results and reference details, order at left...
4.	Genetic Markers (Genetic Marker)IBA 07/01/1994 - "DNA markers YNZ22.1 and YNH37.3 were studied by Southern blotting in 14 patients with typical (11 cases) and atypical (3 cases) type 1 Lissencephaly, all with normal high resolution karyotype" 08/01/1991 - "DNA markers YNZ22.1, YNH37.3, 144D6 and VAW508 were studied in a patient with the isolated lissencephaly sequence (ILS)" 09/01/1991 - "DNA markers YNZ22.1, YNH37.3, 144D6, and VAW508 were studied in five patients with the Miller-Dieker syndrome, 17 patients with the isolated lissencephaly sequence, one patient with a non-classified lissencephaly, and nine patients with an atypical cortical dysplasia" Get all the results and reference details, order at left...
5.	1-Alkyl-2-acetylglycerophosphocholine Esterase (PAF Acetylhydrolase)IBA 12/29/1995 - "Its gamma-subunit (which, formerly, we called the 29-kDa subunit) acts as a catalytic subunit, whereas the alpha-subunit (45 kDa) is the bovine homolog of the product of human LIS-1, the causative gene of Miller-Dieker lissencephaly, indicating that this intracellular PAF acetylhydrolase plays a key role in brain development" 11/01/1997 - "Although the mutation of several genes, including cyclin-dependent kinase 5 (Cdk 5), p35 and LIS1, 45 kDa subunits of platelet-activating factor acetylhydrolase (PAF-AH) Ib, in Miller-Dieker lissencephaly syndrome (MDS) has been reported to cause abnormal laminar structure in the brain, no abnormality was found in yotari by Western blotting with antibodies (Ab's) against these molecules" Get all the results and reference details, order at left...
6.	Complementary DNA (cDNA)IBA 08/01/1996 - "Previously, we isolated several cDNA clones of the LIS1 gene implicated in Miller-Dieker syndrome" 11/20/1995 - "We report here the isolation of a novel cDNA, designated LIS2, that maps to chromosome 2p11.2 by in situ hybridization and demonstrates extremely high sequence similarity to the recently identified LIS1 gene involved in Miller-Dieker lissencephaly at 17p13.3. Specific probes for LIS2 revealed a pattern of expression resembling that of LIS1, although LIS2 is less abundant" Get all the results and reference details, order at left...
7.	Staphylococcal Protein A (A, Protein)IBA 07/21/1994 - "Sequence analysis revealed a striking identity (99%) of the subunit with a protein encoded by the causative gene (LIS-1) for Miller-Dieker lissencephaly, a human brain malformation manifested by a smooth cerebral surface and abnormal neuronal migration" 02/01/1999 - "Mutations in the X-linked gene doublecortin, which encodes a protein with no dear structural homologues, are found in pedigrees in which affected females show "double cortex" syndrome (DC; also known as subcortical band heterotopia or laminar heterotopia) and affected males show X-linked lissencephaly" Get all the results and reference details, order at left...
8.	Dynein ATPase (Dynein)IBA 03/01/2007 - "Classical lissencephaly is caused by mutations in LIS1, which encodes a WD-repeat protein involved in cytoplasmic dynein regulation, mitosis and nuclear migration" 11/01/2007 - "These functions are dependent on their interactions with the retrograde microtubule motor dynein and with its regulator Lis1--a product of the causal gene for isolated lissencephaly sequence (ILS) and Miller-Dieker lissencephaly" Get all the results and reference details, order at left...
9.	DNA (Deoxyribonucleic Acid)IBA 07/01/2006 - "Ten patients were evaluated for the following aspects: classical cytogenetics by karyotyping using solid staining and G-banding; molecular cytogenetics using fluorescent in situ hybridization with a specific probe for the critical region of isolated lissencephaly sequence; and molecular analysis using deoxyribonucleic acid sequencing" 09/01/1991 - "Prenatal diagnosis by DNA analysis allowed exclusion of the recurrence of Miller-Dieker syndrome in a subsequent pregnancy." Get all the results and reference details, order at left...
10.	Carbon MonoxideIBA 06/01/1990 - "It detects two NotI fragments (180 and 320 kb), one of which (320 kb) was shared by YNZ22 and YNH37, two probes previously shown to be co-deleted in all patients with the Miller-Dieker syndrome (MDS)" 12/25/1993 - "The relationship of ABR to Miller-Dieker syndrome, a neurological disorder co-mapping to 17p13.3, is discussed." Get all the results and reference details, order at left...
34 Drugs and Important Bio-Agents and 42 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Anesthesia 01/01/2006 - "We report changes in the biochemical parameters of a patient with double cortex syndrome who was on a KD and who had been scheduled for the treatment of dental caries under sevoflurane anesthesia and acetate Ringer administration" Get all the results and reference details, order at left...
1 Therapies and Procedures and 1 more articles analyzed in the Research Interface, order at left...