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Malformations of Cortical Development

Abnormalities in the development of the CEREBRAL CORTEX. These include malformations arising from abnormal neuronal and glial CELL PROLIFERATION or APOPTOSIS (Group I); abnormal neuronal migration (Group II); and abnormal establishment of cortical organization (Group III). Many INBORN METABOLIC BRAIN DISORDERS affecting CNS formation are often associated with cortical malformations. They are common causes of EPILEPSY and developmental delay.
Also Known As:
Cerebral Cortical Dysplasia; Cortical Dysplasia; Cortical Dysplasia, Cerebral; Malformations of Cerebral Cortex Development; Cerebral Cortical Dysplasias; Cortical Development Malformation; Cortical Development Malformations; Cortical Dysplasia, Generalized; Cortical Dysplasias; Development Malformation, Cortical; Dysplasia, Cerebral Cortical; Dysplasia, Cortical; Dysplasia, Generalized Cortical; Generalized Cortical Dysplasias; Generalized Cortical Dysplasia
Networked: 376 relevant articles (10 outcomes, 54 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hippocampal Sclerosis
2. Drug Resistant Epilepsy
3. Tuberous Sclerosis (Bourneville's Disease)
4. Seizures (Absence Seizure)
5. Neoplasms (Cancer)

Experts

1. Vinters, Harry V: 18 articles (02/2021 - 02/2004)
2. Mathern, Gary W: 16 articles (01/2020 - 02/2004)
3. Aronica, Eleonora: 13 articles (01/2022 - 05/2003)
4. Crino, Peter B: 10 articles (11/2022 - 03/2002)
5. Cepeda, Carlos: 10 articles (01/2020 - 06/2004)
6. Levine, Michael S: 9 articles (01/2020 - 06/2004)
7. Najm, Imad M: 6 articles (12/2017 - 04/2004)
8. Ying, Zhong: 6 articles (12/2017 - 04/2004)
9. Dobyns, William B: 6 articles (09/2015 - 09/2010)
10. André, Véronique M: 6 articles (01/2012 - 06/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Malformations of Cortical Development:
1. trans-sodium crocetinate (crocetin)IBA
2. Tryptophan (L-Tryptophan)FDA Link
3. MTOR InhibitorsIBA
4. mitomycin C-dextranIBA
5. LacosamideFDA Link
6. Proteins (Proteins, Gene)FDA Link
7. Carmustine (FIVB)FDA Link
8. Anticonvulsants (Antiepileptic Drugs)IBA
9. Glutamate Receptors (Glutamate Receptor)IBA
10. alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA

Therapies and Procedures

1. Therapeutics
2. Operative Surgical Procedures
3. Lasers (Laser)
4. Ketogenic Diet
5. Transcranial Magnetic Stimulation