Hereditary Angioedema

Subscribe to Selected New Research on Hereditary Angioedema

386 relevant articles (22 outcomes, 19 trials/studies) found for this Disease

Description: An inherited disorder that is characterized by subcutaneous and submucosal EDEMA in the upper RESPIRATORY TRACT and GASTROINTESTINAL TRACT.

Also Known As:

Angioedema, Hereditary; Hereditary Angioneurotic Edema; Angioedemas, Hereditary; Angioneurotic Edema, Hereditary; Angioneurotic Edemas, Hereditary; Edema, Hereditary Angioneurotic; Edemas, Hereditary Angioneurotic; Hereditary Angioedemas; Hereditary Angioneurotic Edemas

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 18449

Vascular Diseases: 7172

Angioedema: 1146

Hereditary Angioedema: 386

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 420

Inborn Genetic Diseases: 548

Hereditary Angioedema: 386

Skin and Connective Tissue Diseases

Skin Diseases: 5932

Vascular Skin Diseases: 2

Urticaria: 3296

Angioedema: 1146

Hereditary Angioedema: 386

Immune System Diseases: 1232

Hypersensitivity: 35960

Immediate Hypersensitivity: 1235

Urticaria: 3296

Angioedema: 1146

Hereditary Angioedema: 386

Related Diseases

1.	Angioedema
2.	Edema
3.	Urticaria (Hives)
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
5.	Menorrhagia
61 Diseases and 106 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Bork, Konrad: 8 articles (02/2008 - 05/2003)
2.	Varga, Lilian: 5 articles (05/2008 - 04/2005)
3.	Füst, George: 5 articles (05/2008 - 04/2005)
4.	Farkas, Henriette: 5 articles (05/2008 - 04/2005)
5.	Széplaki, Gábor: 5 articles (05/2008 - 04/2005)
6.	Karádi, István: 3 articles (05/2008 - 04/2005)
7.	Lehmann, Andreas: 2 articles (08/2008 - 08/2002)
8.	Prohászka, Zoltán: 2 articles (05/2008 - 04/2007)
9.	Drouet, Christian: 2 articles (02/2008 - 12/2006)
10.	Hardt, Jochen: 2 articles (02/2008 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hereditary Angioedema:

1.	Danazol (Azol)FDA LinkGeneric 01/01/1988 - "A 24-year-old woman, having familial hereditary angioneurotic edema (HAE) treated with danazol, developed an anti-Ro-positive lupus featured by a mild erythematous eruption that seemed initially to decrease and then worsened under danazol, and dramatically improved after danazol was withdrawn" 05/01/1980 - "Danazol is an effective agent for the prophylaxis of the recurrent attacks of mucocutaneous and visceral swelling which occur in patients with hereditary angioedema (HAE)" 04/01/1979 - "Danazol, an attentuated androgen, has been suggested as an effective agent for the prophylaxis of attacks of hereditary angioedema" 04/01/1999 - "PURPOSE: This study evaluated the efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial or dental procedures" 04/01/1999 - "The efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial and dental procedures." Get all the results and reference details, order at left...
2.	Complement System Proteins (Complement)IBA 03/01/1999 - "After C1 inhibitor has for many years been proven beneficial in acute treatment of hereditary angioedema, a growing number of reports now suggests that C1 inhibitor provides an effective means to protect against complement-mediated inflammatory tissue damage" 09/01/2007 - "DISCUSSION: Based on the presence of the typical clinical features and the positive results on the complement tests, we diagnosed hereditary angioedema" 03/01/1992 - "Complement study of the patient's family members revealed that he was one of 5 patients in 3 generations with hereditary angioneurotic edema (HANE)" 07/01/1984 - "Studies of complement autoactivatability in hereditary angioedema: direct relationship to functional C-1-INA and the effect of classical pathway activators." 05/01/1978 - "Since the genes for several disorders of the complement system have been found to be linked to the HLA loci on chromosome 6, studies of the inhibitor of the activated first component of complement (Cl INH) and HLA in two families with hereditary angioedema (HAE) were undertaken" Get all the results and reference details, order at left...
3.	Stanozolol (Winstrol)FDA Link 12/01/1987 - "Thus, stanozolol appears to be a safe and effective agent for management of hereditary angioedema when patients are continually monitored to define the minimal effective dose or the feasibility of stopping the drug." 09/01/2007 - "CONCLUSION: Stanozolol is a safe and effective drug for the long-term management of hereditary angioedema" 09/01/2007 - "CLINICAL IMPLICATIONS: Stanozolol may be used in the long-term treatment of patients with hereditary angioedema provided such patients are closely supervised with routine clinical, biochemical, and radiologic assessments." 09/01/2007 - "OBJECTIVE: To assess the frequencies of various side effects of the attenuated androgen stanozolol in a population of patients with hereditary angioedema treated for 20 to 40 years" 09/01/2007 - "Hereditary angioedema: Safety of long-term stanozolol therapy." Get all the results and reference details, order at left...
4.	SteroidsIBA 02/01/1986 - "Prolonged preventive treatment of hereditary angioneurotic edema with anabolic androgenic steroids]" 01/01/1980 - "Prophylactic treatment of hereditary angioneurotic edema with anabolic steroids." 07/01/1991 - "However, several additional diagnostic possibilities should be pursued in patients with angioedema, such as hereditary angioedema caused by C1-esterase inhibitor deficiency, because anabolic steroids are effective in the treatment of these conditions." 11/01/1994 - "Serial laboratory examinations revealed: [table: see text] CONCLUSIONS: We believe that the occurrence of abdominal pain, facial swelling, and difficulty swallowing suggests that this patient may have experienced a mild, generalized flare of hereditary angioedema during the postoperative period in spite of prophylactic therapy with both anabolic steroids and C1 INH concentrate" 03/01/1989 - "Recognition of their side-effects and complications, comparison of their efficacy with other forms of therapy and more critical evaluation of their value has reduced the range of their definitive indications to a limited number of relatively uncommon situations; these comprise primary hyperplasminaemia, menorrhagia in women in whom oestrogens are contraindicated or in those with von Willebrand's disease, severe traumatic hyphaema, dental extraction in haemophiliacs and hereditary angioedema in patients in whom treatment with anabolic steroids is contraindicated" Get all the results and reference details, order at left...
5.	icatibantIBA 06/01/2007 - "CONCLUSION: Icatibant was effective in treating acute attacks of hereditary angioedema" 01/01/2004 - "Positive results from an icatibant formulation comparative study, in patients with acute attacks of hereditary angioedema, were announced in August 2004; IV and SC formulations showed no difference in efficacy and safety" 01/01/2004 - "The US FDA granted icatibant, for the treatment of hereditary angioedema, fast-track designation in July 2004.In January 2003, the European Agency for the Evaluation of Medicinal Products granted icatibant orphan drug status in Europe for the treatment of angioedema" 12/01/2006 - "Novel pharmacotherapy of acute hereditary angioedema with bradykinin B2-receptor antagonist icatibant." 06/01/2007 - "OBJECTIVE: To assess whether the selective bradykinin receptor-2 antagonist Icatibant is effective in acute edema attacks of hereditary angioedema" Get all the results and reference details, order at left...
6.	BradykininIBA 09/01/2008 - "Studies of the mechanisms of bradykinin generation in hereditary angioedema plasma." 09/01/2008 - "CONCLUSIONS: All parameters indicative of activation of the bradykinin-forming cascade are activated in hereditary angioedema plasma vs normal plasma" 02/01/2008 - "The pathophysiology of hereditary angioedema is presently attributed only to a quantitative/qualitative C1 inhibitor (CI-INH) defect with increased bradykinin release" 01/01/2008 - "However, other systems may play a role in bradykinin's rapid and excessive generation by depleting available levels of C1-inhibitor.There are currently no effective therapies in the United States to treat acute attacks of hereditary angioedema, and currently available agents used to treat hereditary angioedema prophylactically are suboptimal" 01/01/2008 - "CONCLUSIONS: Hereditary angioedema attacks are mediated by bradykinin generated via contact system activation" Get all the results and reference details, order at left...
7.	Tranexamic Acid (AMCA)FDA Link 01/01/1976 - "Six out of 7 Finnish patients suffering from hereditary angioneurotic edema were helped during attacks, by treatment with tranexamic acid (AMCA, Cyklokapron, Kabi) in doses of 1.5 g 3 times daily, follow-up time 3-25 months" 07/01/1991 - "Tranexamic acid in the treatment of hereditary angioedema." 02/01/1985 - "Ten patients with frequent attacks of non-hereditary angioedema were treated with tranexamic acid or placebo in a double blind manner, each period lasting 3 months" 02/01/1985 - "Non-hereditary angioedema treated with tranexamic acid" 08/01/1978 - "Hepatic function and fibrinolysis in patients with hereditary angioedema undergoing long-term treatment with tranexamic acid." Get all the results and reference details, order at left...
8.	Complement C4 (Complement Component 4)IBA 02/01/2004 - "This report describes a patient with hereditary angioedema (HAE) in whom complement C4 values were consistently normal" 02/01/2004 - "Normal complement C4 values do not exclude hereditary angioedema." 07/01/1996 - "A diagnosis of hereditary angioedema was made based on the patient's and family's history and on decreased levels of C1 INH and complement component 4. Standard prophylactic methods were contraindicated due to potential teratogenic effects" 01/01/1988 - "The importance of the examination of C1 inactivator (quantitatively and qualitatively) and of C4 complement fraction in patients with hereditary angioneurotic edema is pointed out." 04/01/2007 - "The association of systemic lupus erythematosus and hereditary angioedema (HAE) has formed the basis of numerous case reports and is hypothesised to result from consumption of complement C4 with consequent impaired clearance of apoptotic cells" Get all the results and reference details, order at left...
9.	Epinephrine (Adrenaline)FDA LinkGeneric 11/01/1999 - "A vote for inhaled adrenaline in the treatment of severe upper airway obstruction caused by piercing of the tongue in hereditary angioedema." 01/01/2001 - "Therapy of acute hereditary angioedema attacks should involve antihistamines, corticosteroids and adrenaline, as well as administration of fresh frozen plasma or infusion of C 1 inhibitor concentrate" 01/01/2005 - "Commonly used agents for airway edema such as glucocorticoids, antihistamines, H1-blockers, and epinephrine tend not to be effective for reducing swelling related to hereditary angioedema." 01/01/2006 - "DISCUSSION: ACE inhibitor-provoked angioedema shares many clinical features with hereditary angioedema (HAE), including a limited effect of steroids, antihistamines and epinephrine" 07/01/1994 - "Treatment of urticaria and acquired angioedema includes histamine receptor blockers, prednisone (for intractable cases), and epinephrine (for respiratory compromise); danazol (Danocrine) or stanozolol (Winstrol) may be useful for prophylaxis of hereditary angioedema." Get all the results and reference details, order at left...
10.	Methyltestosterone (Android)FDA Link 03/01/1977 - "In a double-blind study of four patients with hereditary angioedema, the efficacy of methyltestosterone (taken daily in 10-mg linguet form) in preventing attacks was shown" 03/01/1977 - "Methyltestosterone therapy in hereditary angioedema." 01/01/1980 - "Treatment with 17 alpha-methyltestosterone and with some synthetic androgens prevents attacks of hereditary angioedema (HAE)" 03/01/2004 - "BACKGROUND: The virilizing effects of danazol, stanozolol, and methyltestosterone significantly restrict the usefulness of these agents in the treatment of children with hereditary angioedema (HAE)" Get all the results and reference details, order at left...
125 Drugs and Important Bio-Agents and 361 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Transplants (Transplant) 07/20/2007 - "These results may help to improve therapeutic C1 inhibitor preparations used in the treatment of hereditary angioedema, organ transplant rejection, and heart attack." 08/01/2002 - "Successful off-pump coronary artery bypass graft surgery in a patient with hereditary angioedema." 09/01/2007 - "Important directions are the search for complement inhibitors that (a) interfere with the rejection of transplants; (b) can replace C1 inhibitor in hereditary angioedema, and (c) have a high anti-inflammatory activity in the therapy of rheumatic diseases, diabetes, and other autoimmune disorders" Get all the results and reference details, order at left...
2.	Oral Surgery (Maxillofacial Surgery) 01/01/1993 - "Hereditary angioedema: uncomplicated maxillofacial surgery using short-term C1 inhibitor replacement therapy." 09/01/1988 - "Hereditary angioneurotic edema in oral surgery]" 12/01/1979 - "A case report in which the management of a patient with hereditary angioneurotic edema requiring oral surgery is presented" 06/01/1975 - "Hereditary angioedema: the use of fresh frozen plasma for prophylaxis in patients undergoing oral surgery." 04/01/1999 - "CONCLUSION: The short-term prophylactic use of danazol in patients with hereditary angioedema undergoing oral surgery is an effective preventive measure." Get all the results and reference details, order at left...
3.	Cardiopulmonary Bypass (Heart-Lung Bypass) 04/01/2005 - "Cardiopulmonary bypass in a child with hereditary angioedema." 12/01/2001 - "This case describes the impact of hereditary angioedema and cardiopulmonary bypass on hemostasis as assessed by thrombelastography." 12/01/1993 - "Cardiopulmonary bypass in hereditary angioedema." 08/01/2000 - "C1 esterase inhibitor concentrate during surgery with cardiopulmonary bypass: is there an indication beyond substitution therapy in patients with hereditary angioneurotic edema?" 11/01/2006 - "Uncontrolled kallikrein activation is involved in diseases such as hereditary angioedema, bacterial septic shock and procedures such as cardiopulmonary bypass" Get all the results and reference details, order at left...
4.	Tooth Extraction (Tooth Extractions) 11/01/2003 - "We report a case of a tooth extraction in a patient with hereditary angioedema, for which the C1-inhibitor (C1-INH) concentration administered effectively controlled edema during and after extraction" 08/01/2003 - "Laryngeal edema and death from asphyxiation after tooth extraction in four patients with hereditary angioedema." 01/01/1985 - "Acute airway obstruction following tooth extraction in hereditary angioedema." 01/01/1985 - "Life threatening airway obstruction occurred following a single tooth extraction in a patient who had hereditary angioedema, despite preoperative administration of FFP and danazol" Get all the results and reference details, order at left...
5.	Contraception (Birth Control) 11/01/2008 - "Contraception in hereditary angioedema." 01/01/1990 - "Hereditary angioedema and oral contraception." 03/27/1987 - "Contraception and pregnancy in hereditary angioedema]" Get all the results and reference details, order at left...
27 Therapies and Procedures and 46 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Patient-Physician
Research Summary Report
on Hereditary Angioedema

*WARNING* This specific disease subtype has a relatively small number of significant evidence outcomes. You may proceed to order anyway, or go back to the search field and enter a more general type of the target illness. Once your report has been ordered, however, we can't refund the purchase.

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental.

Free Updates for 1 Year
All 22 Outcomes
Top 125 Key Medications
Top 27 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF for "Psoriasis" >>

Price:

$24.00 & Delivery via PDF download,
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License details >>

Price:

$490.00 access via web interface, 1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m", 1 year subscription

Proceed to Checkout >>