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Neonatal Alloimmune Thrombocytopenia

A condition in newborns caused by immunity of the mother to PLATELET ALLOANTIGENS on the fetal platelets. The PLATELETS, coated with maternal ANTIBODIES, are destroyed and removed by the fetal MONONUCLEAR PHAGOCYTE SYSTEM. Affected infants may have INTRACRANIAL HEMORRHAGES.
Also Known As:
Thrombocytopenia, Neonatal Alloimmune; Alloimmune Thrombocytopenia, Neonatal; Alloimmune Thrombocytopenias, Neonatal; Neonatal Alloimmune Thrombocytopenias; Neonatal Thrombocytopenias; Thrombocytopenia, Neonatal; Thrombocytopenias, Neonatal; Thrombocytopenias, Neonatal Alloimmune; Neonatal Thrombocytopenia
Networked: 445 relevant articles (15 outcomes, 24 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Thrombocytopenia (Thrombopenia)
2. Intracranial Hemorrhages (Intracranial Hemorrhage)
3. Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
4. Hemorrhage
5. Thrombasthenia (Glanzmann Thrombasthenia)

Experts

1. Santoso, Sentot: 18 articles (06/2015 - 02/2002)
2. Aster, Richard H: 9 articles (06/2015 - 08/2004)
3. Kroll, Hartmut: 9 articles (09/2013 - 03/2005)
4. Bein, Gregor: 8 articles (06/2015 - 02/2009)
5. Curtis, Brian R: 8 articles (06/2015 - 08/2004)
6. Husebekk, Anne: 7 articles (06/2015 - 08/2005)
7. McFarland, Janice G: 7 articles (06/2015 - 09/2005)
8. Peterson, Julie A: 7 articles (05/2014 - 09/2005)
9. Bakchoul, Tamam: 7 articles (03/2014 - 02/2009)
10. Kaplan, C: 7 articles (08/2013 - 06/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neonatal Alloimmune Thrombocytopenia:
1. AntibodiesIBA
2. Immunoglobulins (Immunoglobulin)IBA
3. Inosine Triphosphate (ITP)IBA
4. Intravenous Immunoglobulins (IVIG)FDA Link
5. human 1a alloantigen (HPA-1a)IBA
6. Immunoglobulin G (IgG)IBA
7. gamma-Globulins (gamma-Globulin)IBA
8. Prednisolone (Predate)FDA LinkGeneric
9. DNA (Deoxyribonucleic Acid)IBA
10. Prednisone (Sone)FDA LinkGeneric

Therapies and Procedures

1. Platelet Transfusion (Blood Platelet Transfusions)
2. Splenectomy
3. Transplantation (Transplant Recipients)
12/01/2003 - "The alloimmune thrombocytopenias are classified into neonatal alloimmune thrombocytopenia, post-transfusion purpura, passive alloimmune thrombocytopenia, transplantation-associated alloimmune thrombocytopenia, and platelet transfusion refractoriness. "
06/01/2001 - "Although consensus may be less evident on specific triggers for 'difficult' patients, the following triggers, listed by progressively increasing levels, have been proposed in the literature and have found general agreement: a stable oncohematological recipient: 10.000; lumbar puncture in a stable pediatric leukemic patient: 10.000; thrombocytopenia secondary to gpIIb/IIIa receptor inhibitors [corrected]:10.000; bone marrow aspiration and biopsy: 20.000; gastrointestinal endoscopy in cancer: 20.000-40.000; disseminated intravascular coagulation: 20.000-50.000; fiber-optic bronchoscopy in a bone marrow transplant recipient: 20.000-50.000; neonatal alloimmune thrombocytopenia: 30.000; major surgery in leukemia: 50.000; thrombocytopenia secondary to massive transfusion: 50.000; invasive procedures in cirrhosis: 50.000; cardiopulmonary bypass: 50.000-60.000; liver biopsy: 50.000-100.000; a nonbleeding premature infant: 60.000; neurosurgery: 100.000. "
01/01/2005 - "Human platelet alloantigens (HPA) are important in neonatal alloimmune thrombocytopenia (NAIT), posttransfusion purpura (PTP), platelet transfusion refractoriness, passive alloimmune thrombocytopenia, and transplantation-associated alloimmune thrombocytopenia. "
01/01/1998 - "These antibodies are responsible for fetal and neonatal alloimmune thrombocytopenia, posttransfusion purpura, passive alloimmune thrombocytopenia and transplantation-associated thrombocytopenia and may contribute to platelet transfusion refractoriness together with HLA antibodies. "
4. Immunotherapy
5. Cesarean Section (Caesarean Section)