|1.||Takai, Shinji: 57 articles (08/2014 - 02/2002)|
|2.||Miyazaki, Mizuo: 51 articles (08/2014 - 02/2002)|
|3.||Jin, Denan: 33 articles (08/2014 - 02/2002)|
|4.||Muramatsu, Michiko: 19 articles (06/2009 - 09/2002)|
|5.||Urata, Hidenori: 14 articles (12/2015 - 09/2002)|
|6.||Pejler, Gunnar: 11 articles (02/2014 - 03/2009)|
|7.||Fukuda, Yoshiaki: 11 articles (10/2011 - 02/2002)|
|8.||Takai, S: 10 articles (01/2013 - 07/2000)|
|9.||Tomimori, Yoshiaki: 10 articles (10/2011 - 02/2002)|
|10.||Sakaguchi, Masato: 10 articles (04/2005 - 05/2002)|
05/01/2004 - "We recently found that cardiac chymase was activated significantly and survival rate markedly improved by treatment with chymase inhibitors after myocardial infarction (MI) in hamsters. "
04/01/2010 - "We found that combined chymase and ACE inhibition, relative to ACE inhibition alone, improved LV function, decreased adverse cardiac remodeling, and improved survival after myocardial infarction in hamsters. "
01/01/2010 - "Cardiac dysfunction after myocardial infarction was also attenuated by chymase inhibition. "
08/01/2004 - "For example, cardiac chymase was activated earlier than ACE and this activation lasted longer than that of ACE after myocardial infarction (MI) in hamsters. "
05/01/2004 - "An antiarrhythmic effect of a chymase inhibitor after myocardial infarction."
04/01/2010 - "These results suggest that chymase inhibitors could be a useful addition to ACE inhibitor therapy in the treatment of heart failure."
08/01/2008 - "In the group of heart failure patients, the odds ratio of chymase-1 GG genotype having a nonischemic etiology was 2.48 (95% CI 1.23-5.00). "
08/01/2008 - "The chymase-1 -1903 GG genotype was associated with a nonischemic heart failure etiology (chi = 6.67, P = 0.009). "
11/20/2005 - "A dual Ang II forming pathway from both ACE and chymase in the hamster hearts plays an important role during the development of heart failure. "
09/28/1999 - "Mast cells cause apoptosis of cardiomyocytes and proliferation of other intramyocardial cells via the activity of RMCP 1. Our results suggest that mast cell chymase may play a role in the progression of heart failure, because loss of cardiomyocytes and proliferation of nonmyocardial cells exaggerate its pathophysiology."
|3.||Atopic Dermatitis (Atopic Eczema)
11/01/2002 - "Therapeutic potential of a specific chymase inhibitor in atopic dermatitis."
01/01/2001 - "Absence of association between a variant of the mast cell chymase gene and atopic dermatitis in an Italian population."
06/01/1999 - "Association between mast cell chymase genotype and atopic eczema: comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory disease."
09/01/1998 - "No evidence for an association between a variant of the mast cell chymase gene and atopic dermatitis based on case-control and haplotype-relative-risk analyses."
04/01/2005 - "In this study we sought to determine the role of mast cell chymase in atopic dermatitis (AD) in comparison with its role in psoriasis and normal skin. "
08/20/2012 - "Chymase inhibition prevents myocardial fibrosis through the attenuation of NOX4-associated oxidative stress in diabetic hamsters."
08/01/2012 - "The results indicate an important role for chymase in inducing fibrosis through TGF-β1 activation, parallel with Ang II effects."
08/01/2012 - "Similar to HG-stimulated RMCs, control RMCs treated with chymase responded with increased expression of TGF-β1, Smad 3 and fibrosis markers. "
08/01/2012 - "RMCs exposed to HG presented increases in chymase activity and expression, together with upregulation in fibrosis markers and in the TGF-β1 signaling pathway. "
10/01/2011 - "It may also attenuate fibrosis induced by activated chymase after AMI-R."
10/01/2012 - "Such studies, to date, with respect to IBD at least, are descriptive in the clinical context; nonetheless, preclinical studies implicate chymase in the pathogenesis of gut inflammation. "
11/15/2009 - "However, in this study, we show that one of the substances stored within MC granule, chymase, in fact has a protective role in allergic airway inflammation, indicating that MCs may possess both harmful and protective activities in connection with this type of disease. "
04/01/2005 - "Recent studies have demonstrated that chymase inhibitors inhibit skin inflammation. "
03/27/2015 - "Since chymase is released from cardiac mast cells during stress (e.g., volume/pressure overload, inflammation), we hypothesized that GPR30-related cardioprotection after E2 loss might occur through its opposing actions on cardiac mast cell proliferation and chymase production. "
01/03/2014 - "Here we explored the contribution of MCPT4 and human chymase to the control of danger-induced inflammation. "
|3.||Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
|4.||6- (5- chloro- 2- methoxybenzyl)- 4- alarkylaminocarbonyl- 1,4- diazepane- 2,5- dione
|7.||Transforming Growth Factor beta (TGF-beta)
|9.||Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)
|1.||Surgical Instruments (Clip)
|2.||Renal Dialysis (Hemodialysis)
|4.||Angioplasty (Angioplasty, Transluminal)