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Granzymes (Granzyme)

A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.
Also Known As:
Granzyme; Granzyme A; Granzyme B; Cytotoxic Serine Protease B; Cytotoxic T-Lymphocyte Associated 1 Protein; Cytotoxic T-Lymphocyte Proteinase 1; Fragmentin 2; Granzyme C; Granzyme K; Granzyme M; Granzyme-3; Granzyme-Like Protein III; Hanukah Factor; NK-Tryptase-2; Natural Killer Cell Granule Tryptase-2; Cytotoxic T Lymphocyte Associated 1 Protein; Cytotoxic T Lymphocyte Proteinase 1; Granzyme 3; Granzyme Like Protein III; NK Tryptase 2; Natural Killer Cell Granule Tryptase 2
Networked: 2238 relevant articles (56 outcomes, 135 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Granville, David J: 26 articles (01/2022 - 05/2003)
2. Bovenschen, Niels: 21 articles (01/2021 - 06/2008)
3. Trapani, Joseph A: 17 articles (01/2021 - 03/2002)
4. Hodge, Sandra: 14 articles (12/2022 - 12/2006)
5. Simon, Markus M: 14 articles (02/2017 - 07/2002)
6. Bird, Phillip I: 13 articles (01/2021 - 07/2006)
7. Pardo, Julián: 13 articles (01/2021 - 10/2002)
8. Froelich, Christopher J: 13 articles (02/2017 - 10/2002)
9. Smyth, Mark J: 13 articles (01/2015 - 05/2003)
10. Hodge, Greg: 12 articles (12/2022 - 12/2006)

Related Diseases

1. Neoplasms (Cancer)
2. Virus Diseases (Viral Diseases)
3. Infections
4. Human Influenza (Influenza)
5. Colorectal Neoplasms (Colorectal Cancer)

Related Drugs and Biologics

1. Perforin
2. Interleukin-10 (Interleukin 10)
3. Proteins (Proteins, Gene)
4. Interferons
5. Granzymes (Granzyme)
6. Biomarkers (Surrogate Marker)
7. Antigens
8. Vaccines
9. Peptides (Polypeptides)
10. Ligands

Related Therapies and Procedures

1. Immunotherapy
2. Drug Therapy (Chemotherapy)
3. Transplantation
4. Therapeutics
5. Liver Transplantation