A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
Also Known As:
BSC-1 Cell Growth Inhibitor; Cartilage-Inducing Factor-B; Glioblastoma-Derived T-Cell Suppressor Factor; Polyergin; Suppressor Factor, T-Cell, Glioblastoma-Derived; TGF-beta-2; TGF-beta2 Latency-Associated Protein; TGF-beta2LAP; Transforming Growth Factor beta 2 Latency Associated Peptide; BSC 1 Cell Growth Inhibitor; Cartilage Inducing Factor B; Glioblastoma Derived T Cell Suppressor Factor; Latency-Associated Protein, TGF-beta2; TGF beta2 Latency Associated Protein; TGF beta2LAP; TGF-beta2