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Transforming Growth Factor beta1 (TGF beta 1)

A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
Also Known As:
TGF beta 1; TGF-beta-1; TGF-beta1 Latency-Associated Protein; TGF-beta1LAP; Transforming Growth Factor beta 1 Latency Associated Peptide; Transforming Growth Factor beta I; Latency-Associated Protein, TGF-beta1; TGF beta1 Latency Associated Protein; TGF beta1LAP; TGF-beta1; Transforming Growth Factor-beta1
Networked: 5914 relevant articles (174 outcomes, 858 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Kim, Seong-Jin: 18 articles (03/2010 - 01/2002)
2. Lan, Hui Y: 10 articles (05/2010 - 03/2005)
3. Liu, Yong: 10 articles (03/2010 - 01/2003)
4. Chen, Ying: 9 articles (04/2014 - 03/2005)
5. Margetts, Peter J: 9 articles (02/2010 - 10/2001)
6. Jakowlew, Sonia B: 9 articles (06/2008 - 05/2002)
7. Zhang, Wei: 8 articles (02/2020 - 06/2003)
8. Li, Yong: 8 articles (08/2015 - 09/2003)
9. Watanabe, Kenichi: 8 articles (07/2015 - 09/2004)
10. Wang, Xin: 8 articles (06/2014 - 09/2007)

Related Diseases

1. Fibrosis (Cirrhosis)
2. Proteinuria
3. Neoplasms (Cancer)
4. Inflammation (Inflammations)
5. Wounds and Injuries (Trauma)

Related Drugs and Biologics

1. Messenger RNA (mRNA)
2. Proteins (Proteins, Gene)
3. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4. Collagen
5. Transforming Growth Factor beta (TGF-beta)
6. Interleukin-10 (Interleukin 10)
7. Intercellular Signaling Peptides and Proteins (Growth Factors)
8. Peptides (Polypeptides)
9. Transforming Growth Factor beta2
10. Fibronectins (Fibronectin)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Lung Transplantation
4. Immunomodulation
5. Oral Administration