HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Presenilin-2

Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.
Also Known As:
Presenilin 2
Networked: 246 relevant articles (2 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Manabe, Takayuki: 6 articles (05/2010 - 08/2002)
2. Pizzo, Paola: 5 articles (05/2013 - 03/2004)
3. Hong, Jin Tae: 5 articles (02/2012 - 09/2005)
4. Imaizumi, Kazunori: 5 articles (10/2007 - 08/2002)
5. Pozzan, Tullio: 4 articles (10/2012 - 03/2004)
6. Fasolato, Cristina: 4 articles (10/2012 - 03/2004)
7. Katayama, Taiichi: 4 articles (10/2007 - 08/2002)
8. Tohyama, Masaya: 4 articles (10/2007 - 08/2002)
9. Ghidoni, Roberta: 4 articles (04/2007 - 12/2003)
10. Binetti, Giuliano: 4 articles (04/2007 - 12/2003)

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
2. Cholangiocarcinoma
3. Neuroblastoma
4. Frontotemporal Dementia
5. Glioma (Gliomas)

Related Drugs and Biologics

1. Presenilin-1
2. Amyloid Precursor Protein Secretases (beta-Secretase)
3. Endocannabinoids (Endocannabinoid)
4. Amyloid (Amyloid Fibrils)
5. Messenger RNA (mRNA)
6. Apolipoproteins
7. Flavin-Adenine Dinucleotide (FAD)
8. Proteins (Proteins, Gene)
9. Presenilins
10. Amyloid beta-Protein Precursor (Amyloid Protein Precursor)

Related Therapies and Procedures

1. Oral Administration