Presenilin-2

Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.

Also Known As:

Networked: 343 relevant articles (3 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pizzo, Paola: 13 articles (06/2021 - 03/2004)
2.	Pozzan, Tullio: 10 articles (06/2021 - 03/2004)
3.	Fasolato, Cristina: 6 articles (06/2021 - 03/2004)
4.	Filadi, Riccardo: 6 articles (06/2021 - 05/2013)
5.	Greotti, Elisa: 6 articles (06/2021 - 01/2016)
6.	Lardelli, Michael: 6 articles (05/2021 - 01/2018)
7.	Newman, Morgan: 6 articles (05/2021 - 01/2018)
8.	Jayadev, Suman: 6 articles (01/2020 - 04/2010)
9.	Hong, Jin Tae: 6 articles (01/2017 - 09/2005)
10.	Manabe, Takayuki: 6 articles (05/2010 - 08/2002)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 07/25/2012 - "Association studies of presenilin-2 (PSEN2) polymorphisms and sporadic Alzheimer's disease (AD) have yielded inconsistent results, possibly because single studies often lack sufficient statistical power. " 07/18/2008 - "In a previous study, we reported that Alzheimer's disease-associated presenilin-2 interacts with a LIM-domain protein, namely, DRAL/FHL2/SLIM3. " 12/01/2005 - "Genetic studies of families with familial Alzheimer's disease have implicated presenilin 2 (PS2) in the pathogenesis of this disease. " 08/01/2002 - "Previously reported association studies of presenilin 2 (PSEN2) polymorphisms with early-onset Alzheimer disease (EOAD) have produced contradictory results. " 10/01/1999 - "Novel intronic polymorphisms in the presenilin-2 gene and a case-control association study of Alzheimer's disease."
2.	Brain Infarction 01/01/2021 - "Intrahippocampal silencing of XLOC_035088 significantly decreased brain XLOC_035088 expression, reduced brain infarct size, and improved neurological function through inhibiting NOTCH1 following derepression of presenilin 2 (PSEN2). "
3.	Cholangiocarcinoma 05/15/2010 - "AEA increased presenilin 1 expression and recruitment into the gamma-secretase complex, whereas 2-AG increased expression and recruitment of presenilin 2. The development of novel therapeutic strategies aimed at modulating the endocannabinoid system or mimicking the mode of action of AEA on Notch signaling pathways would prove beneficial for cholangiocarcinoma management."
4.	Neuroblastoma 04/21/2002 - "In this study, SK-N-SH human neuroblastoma cells were transfected with wild-type and mutant PS-2 gene to examine presenilin-2 effects on apoptosis. " 05/07/2013 - "Perturbation of MAM function has previously been suggested in Alzheimer's disease (AD) as shown in fibroblasts from AD patients and a neuroblastoma cell line containing familial presenilin-2 AD mutation. " 11/26/1997 - "Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines." 05/15/1999 - "We demonstrated that presenilin 1 and presenilin 2 are proteolytically processed in human glioma cell lines, transfected and untransfected human neuroblastoma SH-SY5Y cells, COS-7 cells, rat cerebellar neuronal ST15 cells, mouse and human brain. " 01/01/2004 - "To investigate the generation of intracellular Abeta, we established human neuroblastoma SH-SY5Y cells stably expressing wild-type amyloid precursor protein (APP), Swedish mutant APP, APP plus presenilin 1 (PS1) and presenilin 2 (PS2; wild-type or familial AD-associated mutant), and quantified intracellular Abeta40 and Abeta42 in formic acid extracts by sensitive Western blotting. "
5.	Frontotemporal Dementia (Semantic Dementia) 11/01/2008 - "A separate study, conducted at the University of Washington, assessed the impact of deterministic genetic testing by disclosing presenilin-1, presenilin-2, or TAU genotype to 22 individuals at risk for familial AD or frontotemporal dementia. " 03/26/2002 - "Mutations of three different genes-amyloid precursor protein (APP), presenilin 1 (PS-1), presenilin 2 (PS-2)-have been found in early-onset autosomal dominant forms of AD, of the human microtubule associated-protein tau gene (MAPT) in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), of the BRI gene in familial British dementia, of the PI12 gene in familial encephalopathy with neuroserpin inclusion bodies. "

Related Drugs and Biologics

1.	Presenilin-1
2.	Amyloid Precursor Protein Secretases (beta-Secretase)
3.	Endocannabinoids
4.	Proteins (Proteins, Gene)
5.	Amyloid (Amyloid Fibrils)
6.	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)
7.	Amyloid beta-Peptides
8.	Apolipoproteins
9.	Messenger RNA (mRNA)
10.	tau Proteins (tau Protein)

Related Therapies and Procedures

1.	Oral Administration