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Interleukin-12 Subunit p35

A subunit of interleukin-12. It binds to the INTERLEUKIN-12 SUBUNIT P40 via a disulfide bond that results in the active cytokine.
Also Known As:
IL-12p35; Interleukin 12a; Interleukin-12 p35; Interleukin 12 Subunit p35; Interleukin 12 p35; Subunit p35, Interleukin-12
Networked: 64 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ghiasi, Homayon: 4 articles (11/2013 - 06/2002)
2. Cua, Daniel J: 2 articles (01/2014 - 08/2006)
3. Mott, Kevin R: 2 articles (11/2013 - 04/2011)
4. Zandian, Mandana: 2 articles (11/2013 - 04/2011)
5. Allen, Sariah J: 2 articles (11/2013 - 04/2011)
6. Ryffel, Bernhard: 2 articles (02/2012 - 01/2012)
7. Kim, Hye Sung: 2 articles (01/2012 - 08/2010)
8. Chung, Doo Hyun: 2 articles (01/2012 - 08/2010)
9. Magez, Stefan: 2 articles (01/2012 - 05/2007)
10. Osorio, Yanira: 2 articles (03/2005 - 06/2002)

Related Diseases

1. Infection
2. Melanoma (Melanoma, Malignant)
3. Colitis
4. Neoplasms (Cancer)
5. Necrosis
12/01/2015 - "The HK macrophages were incubated with ICPs and lipopolysaccharide (LPS), and the responses of cytokine genes, namely interleukin-10 (IL-10), IL-1β, IL-12p35, IL-12p40, IL-18, tumour necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), cyclo-oxygenase-2 (COX-2), interferon-1 (IFN-1), and IFN-γ were assessed by quantitative real-time PCR (qRT-PCR) at 2, 6, 12, 24, and 48 h post-stimulation (hps). "
05/01/2008 - "We measured interferon (IFN)-gamma, tumour necrosis factor-alpha, transforming growth factor (TGF)-beta(1), interleukin (IL)-4, IL-10, IL-12p35 and IL-12p40 mRNA levels by real-time PCR performed on liver samples from HCV mono-infected (n = 19) and HCV/HIV co-infected (n = 24) patients. "
07/01/2002 - "The objective of this study was to evaluate the expression of the immunoregulatory and pro-inflammatory cytokines interleukin (IL)-2, IL-4, IL-6, IL-12p35, IL-12p40, interferon-gamma (IFN-gamma), and tumour necrosis factor-alpha (TNF-alpha), and the expression of the predominantly immunosuppressive cytokines transforming growth factor-beta (TGF-beta) and IL-10 in canine idiopathic lymphocytic-plasmacytic colitis (LPC). "
04/01/2006 - "mRNA expression for the cytokines gamma-interferon (gamma-IFN), interleukin-6 (IL-6), IL-12p35, IL-13, IL-18, and thymus and activation regulated chemokine (TARC) exhibited significant increases during the challenge compared to baseline, but there was no appreciable alteration in expression for tumour necrosis factor-alpha (TNF-alpha), IL-12p40, IL-10, regulated on activation normal T-cell expressed and secreted (RANTES), IL-5, IL-2, IL-4, and IL-8. "

Related Drugs and Biologics

1. adjuvant P40 (P 40)
2. Vaccines
3. N(1)-methyl-2-lysergic acid diethylamide (MIL)
4. Interleukin-12 Subunit p40
5. Messenger RNA (mRNA)
6. Interleukin-10 (Interleukin 10)
7. Interleukin-4 (Interleukin 4)
8. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9. Cytokines
10. Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1. Immunotherapy