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Presenilins

Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.
Also Known As:
Presenilin
Networked: 681 relevant articles (2 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Shen, Jie: 16 articles (11/2014 - 04/2004)
2. De Strooper, Bart: 12 articles (11/2015 - 01/2004)
3. Wolfe, Michael S: 12 articles (11/2014 - 12/2002)
4. Haass, Christian: 9 articles (06/2010 - 06/2002)
5. Iwatsubo, Takeshi: 8 articles (01/2014 - 04/2002)
6. Berezovska, Oksana: 8 articles (01/2014 - 01/2003)
7. Checler, Frédéric: 8 articles (08/2012 - 03/2002)
8. Thinakaran, Gopal: 8 articles (01/2010 - 01/2003)
9. Hyman, Bradley T: 7 articles (01/2014 - 01/2003)
10. Kovacs, Dora M: 7 articles (01/2014 - 12/2002)

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
2. Neuroblastoma
3. Ischemia
4. Neurodegenerative Diseases (Neurodegenerative Disease)
5. Inflammation

Related Drugs and Biologics

1. Amyloid Precursor Protein Secretases (beta-Secretase)
2. Amyloid (Amyloid Fibrils)
3. Proteins (Proteins, Gene)
4. Flavin-Adenine Dinucleotide (FAD)
5. Presenilin-1
6. Amyloid beta-Protein Precursor (Amyloid Protein Precursor)
7. Amyloid beta-Peptides
8. Calcium
9. Apolipoproteins
10. Apolipoproteins E (ApoE)

Related Therapies and Procedures

1. Transplantation (Transplant Recipients)
2. Heart Transplantation (Grafting, Heart)