Interleukin-15 Receptor alpha Subunit

A low affinity interleukin-15 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN to form a high affinity receptor for INTERLEUKIN-15.

Also Known As:

IL-15R alpha; Interleukin-15 Receptor alpha; alpha-Subunit, Receptor, Interleukin-15; IL 15R alpha; Interleukin 15 Receptor alpha; Interleukin 15 Receptor alpha Subunit; Receptor alpha, Interleukin-15; alpha, IL-15R; alpha, Interleukin-15 Receptor

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Interleukin Receptors: 114
        Interleukin-15 Receptors: 66
        Interleukin-15 Receptor alpha Subunit: 10

Experts

1.	Azzarone, Bruno: 2 articles (05/2009 - 02/2009)
2.	Devocelle, Aurore: 2 articles (05/2009 - 02/2009)
3.	Giron-Michel, Julien: 2 articles (05/2009 - 02/2009)
4.	Fukushima, Satoshi: 1 article (05/2021)
5.	Ihn, Hironobu: 1 article (05/2021)
6.	Ishibashi, Takayuki: 1 article (05/2021)
7.	Iwama, Tatsuaki: 1 article (05/2021)
8.	Kanemaru, Hisashi: 1 article (05/2021)
9.	Kimura, Toshihiro: 1 article (05/2021)
10.	Kubo, Yosuke: 1 article (05/2021)

Related Diseases

1.	Epstein-Barr Virus Infections 05/07/2009 - "It has been reported that infectious mononucleosis (IM)-symptomatic primary Epstein-Barr virus infection produces a global down-regulation of interleukin-15 receptor-alpha (IL-15Ralpha) on T cells and natural killer cells associated with a defective IL-15 responsiveness that lasts for many years after the disease episode. "
2.	Schizophrenia (Dementia Praecox) 01/01/2019 - "Schizophrenia Patient Shows a Rare Interleukin 15 Receptor alpha Variant Disrupting Signal Transduction."
3.	Obesity 01/01/2019 - "Lack of interleukin 15 receptor alpha (IL15RA) increases spontaneous activity, exercise capacity and protects from diet-induced obesity by enhancing muscle energy metabolism, suggesting a role as exercise mimetic for IL15RA antagonists. "
4.	Neoplasms (Cancer) 04/15/2008 - "Despite a marked expansion of IL-2/IL-15R beta(+) cells in lymphoid organs and peripheral blood following treatment with IL-15/IL-15R alpha complexes, the destruction of solid tumors was orchestrated by tumor-resident rather than newly infiltrating CD8(+) T cells. " 04/15/2008 - "Here, we report that in vivo delivery of IL-15/IL-15R alpha complexes triggers rapid and significant regression of established solid tumors in two murine models. " 04/15/2008 - "Our data provide novel insights into the use of IL-15/IL-15R alpha complexes to relieve tumor-resident T cells from functional suppression by the tumor microenvironment and have significant implications for cancer immunotherapy and treatment of chronic infections."
5.	Melanoma (Melanoma, Malignant) 05/01/2021 - "Immune cell therapy against disseminated melanoma by utilizing induced pluripotent stem cell-derived myeloid cell lines producing interferon-beta or interleukin-15/interleukin-15 receptor alpha."

Related Drugs and Biologics

1.	Interleukin-15 (Interleukin 15)
2.	Interferon-beta
3.	Lipids
4.	Glycoproteins (Glycoprotein)

Related Therapies and Procedures

1.	Cell- and Tissue-Based Therapy (Cell Therapy)
2.	Immunotherapy