Interleukin-12 Receptors (Interleukin 12 Receptor)

Cell surface receptors for INTERLEUKIN-12. They exist as dimers of beta 1 and beta 2 subunits. Signaling from interleukin-12 receptors occurs through their interaction with JANUS KINASES.

Also Known As:

Interleukin 12 Receptor; Receptors, Interleukin-12; IL-12 Receptor; Interleukin-12 Receptor; Receptor, Interleukin-12; IL 12 Receptor; IL 12 Receptors; Interleukin 12 Receptors; Receptor, IL-12; Receptor, Interleukin 12; Receptors, IL-12; Receptors, Interleukin 12; IL-12 Receptors

Networked: 164 relevant articles (5 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Interleukin Receptors: 114
        Interleukin-12 Receptors: 164
        Interleukin-12 Receptor beta 1 Subunit: 4
        human IL12RB1 protein
        human IL12RB2 protein
        Interleukin-12 Receptor beta 2 Subunit
        mouse Il12rb1 protein
        mouse Il12rb2 protein
        rat Il12rb1 protein
        rat Il12rb2 protein

Experts

1.	Casanova, Jean-Laurent: 10 articles (01/2019 - 06/2003)
2.	Bustamante, Jacinta: 7 articles (10/2020 - 10/2010)
3.	Sanal, Ozden: 4 articles (01/2014 - 01/2003)
4.	Casanova, J L: 4 articles (01/2011 - 05/2001)
5.	Fieschi, Claire: 4 articles (03/2006 - 06/2003)
6.	van de Vosse, Esther: 3 articles (01/2018 - 01/2003)
7.	Boisson-Dupuis, Stéphanie: 3 articles (11/2017 - 10/2010)
8.	Levy, Jacov: 3 articles (01/2016 - 07/2003)
9.	Adusumilli, Prasad S: 3 articles (09/2015 - 02/2013)
10.	Kadota, Kyuichi: 3 articles (09/2015 - 02/2013)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2013 - "High expression of tumor interleukin-12 receptor β2 (IL-12Rβ2) was associated with better outcome (5-year RFP, 90% for high v 80% for low expression; P = .026), whereas high expression of tumor IL-7R was associated with worse outcome (5-year RFP, 76% for high v 86% for low expression; P = .001). " 01/01/2022 - "Cell type-specific IL-12 receptor-KO BM chimera studies revealed that therapeutic modulation of both lymphoid and myeloid cells is required for maximum treatment effect and tumor cure. " 12/01/2005 - "The interleukin-12 receptor beta2 (Il12rb2) gene is silenced in tumor cells from different human B-cell malignancies as opposed to their normal counterparts. " 01/01/2022 - "Study of single-cell data sets from human head and neck carcinomas revealed IL-12 receptor expression patterns similar to those observed in murine tumors. " 02/01/2013 - "Clinical impact of immune microenvironment in stage I lung adenocarcinoma: tumor interleukin-12 receptor β2 (IL-12Rβ2), IL-7R, and stromal FoxP3/CD3 ratio are independent predictors of recurrence."
2.	Allergic Rhinitis 04/01/2015 - "Erratum to: Association study between interleukin-12 receptor β1/β2 genes and allergic rhinitis in the Chinese Han population." 04/01/2015 - "Association study between interleukin-12 receptor β1/β2 genes and allergic rhinitis in the Chinese Han population." 04/01/2015 - "Interleukin-12 (IL-12) plays a key role in the protection against allergic reaction induced by allergen as well as the differentiation of T helper 1 cells in patients with allergic rhinitis (AR), exerting its biological effects through binding to specific IL-12 receptors (IL-12Rs) termed IL-12Rβ1 and IL-12Rβ2. "
3.	Carcinogenesis 01/01/2022 - "rs401502 and rs11575934 Polymorphisms of the IL-12 Receptor Beta 1 Gene are Protective Against Colorectal Carcinogenesis."
4.	Corneal Neovascularization 12/01/2004 - "IL-12 receptor knockout mice given mrIL-12vp showed a marked decrease in the area of corneal neovascularization compared with mice treated with mrIL-12. "
5.	Hypersensitivity (Allergy) 04/01/2015 - "Interleukin-12 (IL-12) plays a key role in the protection against allergic reaction induced by allergen as well as the differentiation of T helper 1 cells in patients with allergic rhinitis (AR), exerting its biological effects through binding to specific IL-12 receptors (IL-12Rs) termed IL-12Rβ1 and IL-12Rβ2. "

Related Drugs and Biologics

1.	Interleukin-12 (IL 12)
2.	Allergens
3.	Cytokines
4.	Interleukin-23 (Interleukin 23)
5.	Messenger RNA (mRNA)
6.	Interferon gamma Receptor
7.	Ligands
8.	Interleukin-12 Subunit p40
9.	Matrix Metalloproteinases (MMPs)
10.	Ki-1 Antigen

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Intranasal Administration