Typhlitis

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83 relevant articles (4 outcomes, 3 trials/studies) found for this Disease

Description: Necrotizing inflammation of the CECUM ("typhlon" in Greek), sometimes spreading to the APPENDIX and/or the ILEUM. Symptoms include ABDOMINAL PAIN and DIARRHEA. Its pathogenesis is multifactorial. Typhlitis is often associated with NEUTROPENIA and chemotherapy in immunocompromised individuals (IMMUNOCOMPROMISED HOST).

Also Known As:

Cecitis; Neutropenic Typhlitis; Typhlitis, Neutropenic

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 29

Gastrointestinal Diseases: 1158

Gastroenteritis: 1701

Typhlitis: 83

Intestinal Diseases: 580

Cecal Diseases: 1

Typhlitis: 83

Related Diseases

1.	Sepsis (Septicemia)
2.	Neutropenia
3.	Mucositis
4.	Abdominal Pain (Pain, Abdominal)
5.	Cardiomyopathies (Cardiomyopathy)
53 Diseases and 57 more articles analyzed in the Research Interface, order at left...

Experts

1.	Edelman, Martin J: 1 article (10/2008)
2.	Shvartsbeyn, Marianna: 1 article (10/2008)
3.	Kerleau, J M: 1 article (05/2007)
4.	Levesque, H: 1 article (05/2007)
5.	Jardin, F: 1 article (05/2007)
6.	Robaday, S: 1 article (05/2007)
7.	Marie, I: 1 article (05/2007)
8.	Sigalet, D L: 1 article (05/2002)
9.	Otaibi, A Al: 1 article (05/2002)
10.	Barker, C: 1 article (05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Typhlitis:

1.	Clindamycin (Cleocin)FDA LinkGeneric 10/01/1989 - "Saccharomyces boulardii, a nonpathogenic yeast, was found to be effective in preventing clindamycin cecitis recurrence in an animal model" 06/01/1981 - "Necropsy findings were indistinguishable from clindamycin-induced cecitis" 05/01/1982 - "To determine whether these vaccines would reduce the severity of antibiotic-associated cecitis, the hamsters were injected subcutaneously with clindamycin" 06/01/1981 - "The absorbable cephalosporins were ineffective in protecting hamsters from clindamycin-induced cecitis" 06/01/1981 - "Daily oral administration of poorly absorbed cephalosporins protected hamsters from clindamycin-induced cecitis and death as long as the cephalosporins were continued" Get all the results and reference details, order at left...
2.	Vancomycin FDA LinkGeneric 01/01/1980 - "Cholestyramine and vancomycin were also tested for therapeutic efficacy in the hamster model of clindamycin-induced cecitis" 10/01/2004 - "Here we compared rifalazil and vancomycin for effectiveness in preventing or treating clindamycin-induced cecitis in a hamster model of CDAD" 03/01/1984 - "Death due to methotrexate-induced cecitis was prevented by daily administration of folinic acid or vancomycin" Get all the results and reference details, order at left...
3.	Cholestyramine (Questran)FDA LinkGeneric 01/01/1980 - "Cholestyramine and vancomycin were also tested for therapeutic efficacy in the hamster model of clindamycin-induced cecitis" Get all the results and reference details, order at left...
4.	Monoclonal AntibodiesIBA 03/01/1991 - "These data show that passive immunity induced by monoclonal antibodies against toxin A was effective against pseudomembranous cecitis." Get all the results and reference details, order at left...
5.	Paclitaxel (Taxol)FDA LinkGeneric 03/01/1993 - "Two cases of typhlitis have occurred after combined treatment with taxol and doxorubicin, while typhlitis has not been described after treatment with either drug alone." 12/01/1995 - "In some studies using regimens combining doxorubicin and paclitaxel, unanticipated toxicities have occurred, such as typhlitis, as well as congestive heart failure at lower than expected cumulative doses of doxorubicin" 03/01/1993 - "In this report the authors describe two cases of typhlitis in patients with metastatic breast cancer treated with taxol and doxorubicin" 03/01/1993 - "Typhlitis resulting from treatment with taxol and doxorubicin in patients with metastatic breast cancer." 08/01/1996 - "Toxicity problems have emerged using anthracyclines and paclitaxel, with sequence- and schedule-dependent toxic effects including dose-limiting typhlitis and mucositis, as well as febrile neutropenia and, in one study, cardiomyopathy" Get all the results and reference details, order at left...
6.	AnthracyclinesIBA 08/01/1996 - "Toxicity problems have emerged using anthracyclines and paclitaxel, with sequence- and schedule-dependent toxic effects including dose-limiting typhlitis and mucositis, as well as febrile neutropenia and, in one study, cardiomyopathy" 04/01/2002 - "In a retrospective analysis of 161 consecutive adult patients with de novo acute myeloid leukemia undergoing induction therapy, including cytarabine, etoposide and anthracyclines, seven patients (4.3%) developed typhlitis" Get all the results and reference details, order at left...
7.	Doxorubicin (Adriamycin)FDA LinkGeneric 03/01/1993 - "Two cases of typhlitis have occurred after combined treatment with taxol and doxorubicin, while typhlitis has not been described after treatment with either drug alone." 12/01/1995 - "In some studies using regimens combining doxorubicin and paclitaxel, unanticipated toxicities have occurred, such as typhlitis, as well as congestive heart failure at lower than expected cumulative doses of doxorubicin" 03/01/1993 - "In this report the authors describe two cases of typhlitis in patients with metastatic breast cancer treated with taxol and doxorubicin" 03/01/1993 - "Typhlitis resulting from treatment with taxol and doxorubicin in patients with metastatic breast cancer." Get all the results and reference details, order at left...
8.	Anti-Bacterial Agents (Antibiotics)IBA 08/01/2002 - "CONCLUSIONS: Pediatric cancer patients with typhlitis can be treated carefully nonoperatively with bowel rest, antibiotics, and supplemental nutrition" 08/01/1995 - "Use of antibiotics to prevent hepatitis and typhlitis in male scid mice spontaneously infected with Helicobacter hepaticus." 05/01/2002 - "With the onset of abdominal pain, 73 of 97 patients were placed on therapeutic antibiotics; patients identified with typhlitis had amphotericin plus GCSF added" 05/01/2002 - "Nonspecific abdominal pain developed on the 12 +/- 11th day posttransplant, whereas patients in whom typhlitis developed were diagnosed on day 15.5 +/- 7. All patients were treated with prophylactic antibiotics consisting of acyclovir, fluconazole, and septra" 06/01/1985 - "Hamsters given the new penicillin temocillin, either orally or by injection, did not develop antibiotic-associated colitis, whereas animals given the control antibiotics cefoxitin or clindamycin developed the disease, which is characterized by marked hemorrhagic cecitis and high cecal levels of Clostridium difficile cytotoxin." Get all the results and reference details, order at left...
9.	Streptomycin (Streptomycin Sulfate)FDA Link 10/01/1994 - "Gross examination revealed soft fecal pellets on PID 7 and 14 and catarrhal typhlitis on PID 14, irrespective of streptomycin pretreatment" 10/01/1948 - "Cure of ulcerative cecitis of rats by streptomycin." 08/01/2006 - "Two common models of infectious murine colitis and typhlitis are infection with the murine epithelial-adherent pathogen, Citrobacter rodentium, and infection of streptomycin-pretreated mice with Salmonella typhimurium" Get all the results and reference details, order at left...
10.	Penicillins (Penicillin)FDA Link 08/01/1980 - "These results implicate C difficile as an agent of penicillin-induced lethal hemorrhagic cecitis in guinea pigs." 08/01/1980 - "Penicillin treatment resulted in lethal hemorrhagic cecitis in seven of eight guinea pigs" 08/01/1980 - "Clostridium difficile-associated cecitis in guinea pigs exposed to penicillin." 12/29/1950 - "A modern orientation of treatment in acute stercoraceous typhlitis with penicillin and sulfaguanidine.]" 06/01/1985 - "Hamsters given the new penicillin temocillin, either orally or by injection, did not develop antibiotic-associated colitis, whereas animals given the control antibiotics cefoxitin or clindamycin developed the disease, which is characterized by marked hemorrhagic cecitis and high cecal levels of Clostridium difficile cytotoxin." Get all the results and reference details, order at left...
61 Drugs and Important Bio-Agents and 50 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 07/15/2005 - "To identify risk factors for typhlitis, the authors compared the demographic data and previous drug therapy of 78 patients who had typhlitis and 1231 identically treated children who did not" 07/15/2005 - "BACKGROUND: Typhlitis is increasingly recognized in children undergoing chemotherapy but is poorly characterized" 02/02/1997 - "Typhlitis (from Greek, "typhlon", cecum) is an inflammatory process involving the cecum and ascending colon--in neutropenic patients after chemotherapy" 11/01/1994 - "RESULTS: This case emphasizes the multifactorial pathogenesis of typhlitis, which may occur in the absence of chemotherapy" 11/01/1994 - "Typhlitis in the absence of chemotherapy is rare" Get all the results and reference details, order at left...
2.	Transplants (Transplant) 05/01/2002 - "This study reviews the authors' experience with abdominal pain and typhlitis in an active pediatric bone marrow transplant program" 05/01/2002 - "CONCLUSIONS: Abdominal pain is a common symptom after bone marrow transplant; however, typhlitis is relatively rare, and surgical intervention was not required in this series" 05/01/2002 - "METHODS: The Pediatric Bone Marrow Transplant Program Database was reviewed for patients presenting with abdominal pain or typhlitis" 05/01/2002 - "Neutropenic enterocolitis (typhlitis) after pediatric bone marrow transplant." 06/01/2000 - "Neutropenic typhlitis is the most severe gastrointestinal manifestation of MBI, but it also influences the occurrence of other major transplant-related complications including acute GVHD, veno-occlusive disease and systemic infections" Get all the results and reference details, order at left...
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/01/1992 - "A case of typhlitis which complicated the course of autologous bone marrow transplantation (ABMT) is reported" 01/01/1992 - "Typhlitis occurring in autologous bone marrow transplantation." 05/01/2002 - "BACKGROUND/PURPOSE: Neutropenic enterocolitis (typhlitis) is a common consideration after bone marrow transplantation" 11/01/1992 - "Other gastrointestinal tract complications of immunosuppression are discussed, including graft-versus-host disease following bone marrow transplantation, typhlitis, and pseudomembranous colitis." 07/01/1998 - "We report on the case of a 24-year-old white man with a history of chronic leukemia treated with unrelated bone marrow transplantation and chemotherapy who was correctly diagnosed with appendicitis rather than typhlitis" Get all the results and reference details, order at left...
4.	Transplantation (Transplant Recipients) 09/01/2008 - "The major gastrointestinal complications include typhlitis (neutropenic enterocolitis), pseudomembranous enterocolitis, viral enteritis, graft-versus-host disease, benign pneumatosis intestinalis, intestinal thrombotic microangiopathy, and post-transplantation lymphoproliferative disease" 05/01/1992 - "Disease entities include opportunistic infections, Kaposi's sarcoma, lymphoma and other B cell proliferative disorders, cancer following transplantation, typhlitis, and pseudomembranous colitis." Get all the results and reference details, order at left...
5.	Laparotomy 12/01/2006 - "RESULTS AND CONCLUSION: These ten cases presented with symptoms suggestive of typhlitis, with further peritonitis requiring laparotomy and small bowel segmental resection" 01/01/1980 - "We strongly recommend that laparotomy be considered in selected patients with typhlitis occurring as a complication of treated leukemia." Get all the results and reference details, order at left...
12 Therapies and Procedures and 39 more articles analyzed in the Research Interface, order at left...

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