Interleukin-13 Receptor alpha2 Subunit

An interleukin-13 receptor subunit that is closely-related to the INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT. The receptor is found as a monomeric protein and has been considered to be a decoy receptor for interleukin-13 due the fact that it lacks cytoplasmic signaling domains.

Also Known As:

Antigens, CD213a2; CD213a2 Antigen; IL-13 Receptor alpha2; IL13Ralpha2; Interleukin-13 Decoy Receptor; Interleukin-13 Receptor alpha2; Interleukin-13 Receptor alpha2 Chain; Antigen, CD213a2; Decoy Receptor, Interleukin-13; IL 13 Receptor alpha2; Interleukin 13 Decoy Receptor; Interleukin 13 Receptor alpha2; Interleukin 13 Receptor alpha2 Chain; Interleukin 13 Receptor alpha2 Subunit; Interleukin-13 alpha2 Receptor; Receptor alpha2, IL-13; Receptor alpha2, Interleukin-13; alpha2 Receptor, Interleukin-13; CD213a2 Antigens; Receptor, Interleukin-13 alpha2

Networked: 50 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Interleukin Receptors: 114
        Interleukin-13 Receptors: 261
        Interleukin-13 Receptor alpha2 Subunit: 50
        human IL13RA2 protein

Experts

1.	Puri, Raj K: 11 articles (05/2020 - 10/2002)
2.	Joshi, Bharat H: 5 articles (05/2020 - 10/2002)
3.	Debinski, Waldemar: 4 articles (10/2008 - 11/2002)
4.	Madhankumar, A B: 4 articles (10/2008 - 11/2002)
5.	Mintz, Akiva: 4 articles (10/2008 - 11/2002)
6.	Fujisawa, Toshio: 3 articles (05/2020 - 11/2009)
7.	Leland, Pamela: 3 articles (05/2020 - 06/2008)
8.	Shimamura, Takeshi: 3 articles (05/2020 - 09/2006)
9.	Jensen, Michael C: 3 articles (01/2014 - 12/2004)
10.	Joshi, Bharat: 3 articles (11/2012 - 11/2009)

Related Diseases

1.	Glioma (Gliomas) 10/01/2008 - "Mice immunized with either recombinant or genetic IL13Ralpha2, but not mock-immunized controls, demonstrated complete protection against IL13Ralpha2( + ) glioma growth and mortality. " 06/01/2008 - "Identification of interleukin-13 receptor alpha2 chain overexpression in situ in high-grade diffusely infiltrative pediatric brainstem glioma." 02/01/2007 - "Novel recombinant adenoviral vector that targets the interleukin-13 receptor alpha2 chain permits effective gene transfer to malignant glioma." 05/01/2005 - "None of the malignant glioma cell lines cultivated in vitro and tested to date exhibited the IL13Ralpha2 receptor. " 05/01/2005 - "Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells."
2.	Breast Neoplasms (Breast Cancer) 07/25/2015 - "Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis." 07/25/2015 - "Furthermore, IL13Ralpha2 silencing was associated with enhanced IL-13-mediated phosphorylation of signal transducer and activator of transcription 6 (STAT6) and impaired migratory ability of metastatic breast cancer cells. " 07/25/2015 - "We found that overexpression of the decoy receptor IL13Ralpha2 is significantly enriched in basal compared with luminal primary breast tumors as well as in a subset of metastatic basal-B breast cancer cells. " 07/25/2015 - "Depletion of IL13Ralpha2 in metastatic breast cancer cells modestly delayed primary tumor growth but dramatically suppressed lung metastasis in vivo. " 07/25/2015 - "Importantly, breast cancer patients with high-grade tumors and increased IL13Ralpha2 levels had significantly worse prognosis for metastasis-free survival compared with patients with low expression. "
3.	Neoplasms (Cancer) 11/15/2012 - "Previous genome-wide expression studies have demonstrated the overexpression of interleukin-13 receptor alpha2 (IL13Rα2) in some human malignancies. " 09/01/2007 - "Increased expression of the IL13Ralpha2 gene relative to nonneoplastic brain was observed in 36 of 81 (44%) and 8 of 17 (47%) tumor specimens by microarray and quantitative real-time reverse transcription PCR analyses, respectively. " 12/17/2001 - "In vivo overexpression of IL-13 receptor alpha2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice." 05/01/2009 - "IL-13 receptor-alpha2: a novel target for cancer therapy." 11/01/2019 - "The interleukin-13 receptor alpha2 (IL13RA2), which is known to be overexpressed in glioblastoma multiforme, plays a role in various cellular processes such as cell migration that may contribute to tumor progression. "
4.	Glioblastoma (Glioblastoma Multiforme) 09/01/2007 - "Expression of interleukin-13 receptor alpha2 in glioblastoma multiforme: implications for targeted therapies." 11/01/2019 - "The interleukin-13 receptor alpha2 (IL13RA2), which is known to be overexpressed in glioblastoma multiforme, plays a role in various cellular processes such as cell migration that may contribute to tumor progression. " 12/04/2017 - "The interleukin-13 receptor alpha2 (IL-13Rα2) is a cancer-associated receptor overexpressed in human glioblastoma multiforme (GBM). " 09/01/2008 - "The majority of glioblastoma multiforme (GBM) tumors (80%) overexpress interleukin-13 receptor alpha2 (IL-13Ralpha2), but there is no expression of IL-13Ralpha2 in normal brain. " 09/01/2007 - "To determine possible explanations for this result, we analyzed the relative expression levels of IL13Ralpha2 in glioblastoma multiforme and nonneoplastic brain specimens using publicly available oligonucleotide microarray databases, quantitative real-time reverse transcription PCR, and immunohistochemical staining. "
5.	Prostatic Neoplasms (Prostate Cancer) 06/15/2010 - "LNCaP prostate cancer cells stably transfected with IL13Ralpha2 were examined for accelerated growth in athymic mice. " 06/15/2010 - "Availability of a human prostate cancer cell line with high level of IL13Ralpha2 expression will facilitate the development of therapeutic modalities. " 06/15/2010 - "Importantly, the ARCaP lineage represented the only human prostate cancer cell line that expresses IL13Ralpha2 proteins at the level detectable by Western blotting. " 11/15/2008 - "Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo: a novel approach to sensitize prostate cancer to anticancer therapy." 11/01/2001 - "Gene transfer of interleukin 13 receptor alpha2 chain dramatically enhances the antitumor effect of IL-13 receptor-targeted cytotoxin in human prostate cancer xenografts."

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Interleukin-13
3.	Proteins (Proteins, Gene)
4.	Interleukin-13 Receptors (Interleukin 13 Receptor)
5.	Antigens
6.	Interleukin-13 Receptor alpha2 Subunit
7.	Epitopes
8.	Interleukins
9.	Cytotoxins (Cytolysins)
10.	Vaccines

Related Therapies and Procedures

1.	Therapeutics