|1.||Puri, Raj K: 11 articles (01/2010 - 10/2002)|
|2.||Joshi, Bharat H: 4 articles (05/2009 - 10/2002)|
|3.||Madhankumar, A B: 4 articles (10/2008 - 11/2002)|
|4.||Mintz, Akiva: 4 articles (10/2008 - 11/2002)|
|5.||Debinski, Waldemar: 4 articles (10/2008 - 11/2002)|
|6.||Kawakami, Mariko: 4 articles (09/2006 - 12/2003)|
|7.||Jensen, Michael C: 3 articles (01/2014 - 12/2004)|
|8.||Joshi, Bharat: 3 articles (11/2012 - 11/2009)|
|9.||Gibson, Aaron M: 3 articles (09/2008 - 12/2006)|
|10.||Tabata, Yasuhiro: 3 articles (09/2008 - 12/2006)|
10/01/2008 - "Mice immunized with either recombinant or genetic IL13Ralpha2, but not mock-immunized controls, demonstrated complete protection against IL13Ralpha2( + ) glioma growth and mortality. "
01/01/2014 - "The interleukin-13 receptor alpha2 (IL13Rα2) is a cell surface receptor that is over-expressed by a subset of high-grade gliomas, but not expressed at significant levels by normal brain tissue. "
06/01/2008 - "Identification of interleukin-13 receptor alpha2 chain overexpression in situ in high-grade diffusely infiltrative pediatric brainstem glioma."
09/01/2007 - "Interleukin-13 receptor alpha2 (IL-13Ralpha2) is a glioma-restricted cell-surface epitope not otherwise detected within the central nervous system. "
02/01/2007 - "Novel recombinant adenoviral vector that targets the interleukin-13 receptor alpha2 chain permits effective gene transfer to malignant glioma."
|2.||Breast Neoplasms (Breast Cancer)
01/01/2015 - "Our findings indicate that IL13Ralpha2 could be used as a promising biomarker to predict patient outcome and provide a rationale for assessing the efficacy of anti-IL13Ralpha2 therapies in a subset of highly aggressive basal-like breast tumors as a strategy to prevent metastatic disease."
01/01/2015 - "Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis."
01/01/2015 - "Furthermore, IL13Ralpha2 silencing was associated with enhanced IL-13-mediated phosphorylation of signal transducer and activator of transcription 6 (STAT6) and impaired migratory ability of metastatic breast cancer cells. "
01/01/2015 - "We found that overexpression of the decoy receptor IL13Ralpha2 is significantly enriched in basal compared with luminal primary breast tumors as well as in a subset of metastatic basal-B breast cancer cells. "
01/01/2015 - "Depletion of IL13Ralpha2 in metastatic breast cancer cells modestly delayed primary tumor growth but dramatically suppressed lung metastasis in vivo. "
05/01/2009 - "IL-13 receptor-alpha2: a novel target for cancer therapy."
09/01/2007 - "Immunohistochemical staining of tumor specimens showed highly variable expression of IL13Ralpha2 protein both within and across specimens. "
09/01/2007 - "Increased expression of the IL13Ralpha2 gene relative to nonneoplastic brain was observed in 36 of 81 (44%) and 8 of 17 (47%) tumor specimens by microarray and quantitative real-time reverse transcription PCR analyses, respectively. "
12/17/2001 - "In vivo overexpression of IL-13 receptor alpha2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice."
09/01/2008 - "The majority of glioblastoma multiforme (GBM) tumors (80%) overexpress interleukin-13 receptor alpha2 (IL-13Ralpha2), but there is no expression of IL-13Ralpha2 in normal brain. "
|4.||Prostatic Neoplasms (Prostate Cancer)
06/15/2010 - "LNCaP prostate cancer cells stably transfected with IL13Ralpha2 were examined for accelerated growth in athymic mice. "
06/15/2010 - "Availability of a human prostate cancer cell line with high level of IL13Ralpha2 expression will facilitate the development of therapeutic modalities. "
06/15/2010 - "Importantly, the ARCaP lineage represented the only human prostate cancer cell line that expresses IL13Ralpha2 proteins at the level detectable by Western blotting. "
11/15/2008 - "Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo: a novel approach to sensitize prostate cancer to anticancer therapy."
11/01/2001 - "Gene transfer of interleukin 13 receptor alpha2 chain dramatically enhances the antitumor effect of IL-13 receptor-targeted cytotoxin in human prostate cancer xenografts."
02/01/2007 - "Allergen-dependent solubilization of IL-13 receptor alpha2 reveals a novel mechanism to regulate allergy."
12/01/2006 - "Allergy-driven alternative splicing of IL-13 receptor alpha2 yields distinct membrane and soluble forms."
08/01/2010 - "FcepsilonRI(-/-) mice exhibited lower IL-13 levels and treatment of WT mice with IL-13 receptor alpha2 prevented peanut-induced intestinal allergy and inflammation. "
|3.||Interleukin-13 Receptors (Interleukin 13 Receptor)
|4.||Interleukin-13 Receptor alpha2 Subunit
|7.||Transforming Growth Factor beta1 (TGF beta 1)
|9.||STAT6 Transcription Factor
|10.||A-Form DNA (A-DNA)
|1.||Heterologous Transplantation (Xenotransplantation)