Interleukin-21 Receptors

Cell surface receptors for interleukin 21. They are heterodimeric proteins found on DENDRITIC CELLS and LYMPHOCYTES that consist of the INTERLEUKIN-21 RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR COMMON BETA SUBUNIT.

Also Known As:

Receptors, Interleukin-21; IL-21 Receptor; IL21R; Interleukin-21 Receptor; Receptor, Interleukin-21; IL 21 Receptor; IL 21 Receptors; Interleukin 21 Receptor; Interleukin 21 Receptors; Receptor, IL-21; Receptor, Interleukin 21; Receptors, IL-21; Receptors, Interleukin 21; IL-21 Receptors

Networked: 121 relevant articles (3 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Interleukin Receptors: 114
        Interleukin-21 Receptors: 121
        Interleukin Receptor Common gamma Subunit: 42
        Interleukin-21 Receptor alpha Subunit

Experts

1.	Leonard, Warren J: 11 articles (12/2021 - 09/2005)
2.	Spolski, Rosanne: 11 articles (12/2021 - 09/2005)
3.	Yoshikai, Yasunobu: 4 articles (01/2018 - 01/2016)
4.	Young, Deborah: 4 articles (04/2014 - 01/2009)
5.	Annex, Brian H: 3 articles (12/2021 - 05/2015)
6.	Wang, Tao: 3 articles (12/2021 - 05/2015)
7.	Kopf, Manfred: 3 articles (01/2019 - 07/2008)
8.	Sun, Xun: 3 articles (01/2018 - 01/2016)
9.	Collins, Mary: 3 articles (01/2009 - 04/2007)
10.	Boztug, Kaan: 2 articles (01/2021 - 06/2015)

Related Diseases

1.	Infections 01/01/2013 - "Interleukin-21 receptor signalling is important for innate immune protection against HSV-2 infections." 01/01/2021 - "This suggests that the IL-21 receptor could be a novel marker of CD8+ T-cell dysfunction during HIV-1 infection." 01/01/2021 - "Little is known about the expression of interleukin-21 receptor (IL-21R) during HIV-1 infection or its role in HIV-1-specific CD8+ T-cell maintenance and subsequent viral control. " 01/01/2021 - "HIV-1 infection and the lack of viral control are associated with greater expression of interleukin-21 receptor on CD8+ T cells." 01/01/2018 - "We found that the absolute number of short-lived effector CD8+ T cells (SLECs) (KLRG1high CD127low) decreased significantly in IL-21 receptor-deficient (IL-21R-/-) mice during Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection. "
2.	Rheumatoid Arthritis 08/01/2023 - "Recently, the dysregulation of interleukin-21 receptor (IL-21R) has been incriminated in different autoimmune and auto-inflammatory diseases, such as systemic lupus erythematous, rheumatoid arthritis, and type 1 diabetes. " 04/01/2007 - "Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis." 05/15/2020 - "Nobiletin suppresses IL-21/IL-21 receptor-mediated inflammatory response in MH7A fibroblast-like synoviocytes (FLS): An implication in rheumatoid arthritis." 01/01/2019 - "Corrigendum: Increased Binding of Specificity Protein 1 to the IL21R Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis." 01/01/2018 - "Increased Binding of Specificity Protein 1 to the IL21R Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis."
3.	Pancreatitis 02/15/2014 - "The improved health of Il2(-/-)Il21r(-/-) mice was reflected in reduced pancreatitis and hemolytic anemia and this was associated with distinct changes in lymphocyte effector populations, including the reduced expansion of both T follicular helper cells and Th17 cells and a compensatory increase in IL-22 in the absence of IL-21R. "
4.	Hemolytic Anemia 02/15/2014 - "The improved health of Il2(-/-)Il21r(-/-) mice was reflected in reduced pancreatitis and hemolytic anemia and this was associated with distinct changes in lymphocyte effector populations, including the reduced expansion of both T follicular helper cells and Th17 cells and a compensatory increase in IL-22 in the absence of IL-21R. "
5.	Neoplasms (Cancer) 01/01/2019 - "In summary, our data showed an association of IL-21+ immune cell infiltration and IL-21 receptor expression in PDAC with poor survival, most likely due to an IL-21-mediated promotion of tumor cell invasion and enhanced colony formation, supporting the notion of the tumor-promoting abilities of the tumor microenvironment." 01/01/2019 - "Interleukin-21 receptor (IL-21R) is involved in the immunological regulation of immune cells and tumor progression in multiple malignancies. " 10/01/2009 - "All MCL cell lines and tumors examined expressed the IL-21 receptor. " 08/01/2009 - "By reverse transcription-PCR, we found consistent expression of IL-21 receptor (IL-21R) in all ALK(+)ALCL cell lines and frozen tumors examined. " 01/01/2018 - "IL-21 receptor signaling is essential for control of hepatocellular carcinoma growth and immunological memory for tumor challenge."

Related Drugs and Biologics

1.	interleukin-21 (interleukin 21)
2.	Interleukin-2 (IL2)
3.	Interleukin-22 (IL-22)
4.	Interleukin-21 Receptors
5.	Interleukin-10 (Interleukin 10)
6.	Cytokines
7.	Interleukin-4 (Interleukin 4)
8.	Interleukins
9.	Immunoglobulin E (IgE)
10.	Myelin-Oligodendrocyte Glycoprotein

Related Therapies and Procedures

1.	Therapeutics