Interleukin-15 Receptors (Interleukin 15 Receptor)

Cell surface receptors for INTERLEUKIN-15. They are widely-distributed heterotrimeric proteins consisting of the INTERLEUKIN-15 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2, 15 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.

Also Known As:

Networked: 66 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wong, Hing C: 5 articles (01/2022 - 12/2011)
2.	Kong, Lin: 3 articles (01/2022 - 12/2011)
3.	Liu, Bai: 3 articles (01/2022 - 12/2011)
4.	Rhode, Peter R: 3 articles (01/2022 - 12/2011)
5.	Zhu, Xiaoyun: 3 articles (01/2022 - 12/2011)
6.	Jeng, Emily K: 2 articles (01/2022 - 05/2013)
7.	Fehniger, Todd A: 2 articles (11/2017 - 11/2002)
8.	Gu, Yanhong: 2 articles (05/2015 - 02/2009)
9.	Cheng, Liang: 2 articles (12/2014 - 11/2014)
10.	Du, Xuexiang: 2 articles (12/2014 - 11/2014)

Related Diseases

1.	Neoplasms (Cancer) 04/15/2012 - "Expression of the IL-15 receptor α on cancer cells was needed to efficiently induce granulated NK cells, and expression on host stromal cells was essential to prevent tumor relapse after near complete destruction. " 05/15/2008 - "The soluble alpha chain of interleukin-15 receptor: a proinflammatory molecule associated with tumor progression in head and neck cancer." 01/01/2022 - "We found that macrophages contributed to the resistance of tumor cells to IL-15, and tumor cells induced macrophages to express high levels of the α subunit of the IL-15 receptor (IL-15Rα). " 01/01/2015 - "Among the signal transduction pathways triggered by the engagement of IL-15 receptor with its ligand, the PI3K-AKT-mTOR pathway seems to be critical for the IL-15-mediated activation of NK cells, therefore being responsible for efficient anti-viral and anti-tumor responses. " 01/15/2000 - "Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma."
2.	Melanoma (Melanoma, Malignant) 01/01/2023 - "The aim of this study is to investigate the possible role of Interleukin-15/Interleukin-15 Receptor α (IL-15/IL-15Rα) complexes in melanoma development. " 01/01/2016 - "ALT-803, a novel IL-15/IL-15 receptor alpha complex, and the tyrosine kinase inhibitor, sunitinib, were examined for their single and combined effects on the growth of subcutaneous B16BL6 melanoma and on lymph node and lung metastasis. " 01/01/2022 - "Herein, we show that the immunotherapeutic HCW9218, comprising transforming growth factor-β (TGF-β) receptor II and interleukin (IL)-15/IL-15 receptor α domains, enhances metabolic and cytotoxic activities of immune cells and reduces TIS tumor cells in vivo to improve the efficacy of docetaxel and gemcitabine plus nab-paclitaxel against B16F10 melanoma and SW1990 pancreatic tumors, respectively. "
3.	Breast Neoplasms (Breast Cancer) 05/01/2019 - "Previous studies have revealed that upregulation of interleukin 15 receptor α (IL15RA) contributes to improved prognosis of breast cancer. "
4.	Obesity 01/01/2011 - "Interleukin-15, IL-15 Receptor-Alpha, and Obesity: Concordance of Laboratory Animal and Human Genetic Studies." 04/01/2016 - "The objective of the current study is to investigate the therapeutic effects of interleukin 15/soluble interleukin 15 receptor-α (IL-15/sIL-15Rα) on high-fat diet-induced obesity and obesity-associated metabolic disorders. "
5.	Liver Neoplasms (Liver Cancer) 11/01/2014 - "Our recent study demonstrates that hyper-IL-15, composed of IL-15 and the sushi domain of IL-15 receptor α chain, provides an effective therapy against well-established metastatic and autochthonous liver cancers in mouse models by triggering activation and expansion of hepatic CD8+ T cells." 12/01/2014 - "Here, we studied the therapeutic effects of hyper-interleukin15 (hyper-IL-15), which is composed of IL-15 and the sushi domain of the IL-15 receptor α chain, on metastatic and autochthonous liver cancers. "

Related Drugs and Biologics

1.	Interleukins
2.	Transforming Growth Factors (Transforming Growth Factor)
3.	Gemcitabine
4.	Docetaxel (Taxotere)
5.	130-nm albumin-bound paclitaxel
6.	Interleukin-15 (Interleukin 15)
7.	Interleukin-15 Receptors (Interleukin 15 Receptor)
8.	Therapeutic Uses
9.	Focal Adhesion Protein-Tyrosine Kinases
10.	Interferon-gamma (Interferon, gamma)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy