Naphthalimides

Compounds with three fused rings that appear like a naphthalene fused to piperidone or like a benz(de)isoquinoline-1,3-dione (not to be confused with BENZYLISOQUINOLINES which have a methyl separating the naphthyl from the benzyl rings). Members are CYTOTOXINS.

Also Known As:

Networked: 116 relevant articles (9 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhao, Jin: 10 articles (02/2021 - 01/2009)
2.	Qian, Xuhong: 7 articles (08/2022 - 04/2007)
3.	Li, Qian: 7 articles (02/2021 - 01/2011)
4.	Xu, Yufang: 6 articles (08/2022 - 04/2007)
5.	Wang, Chaojie: 6 articles (10/2021 - 04/2011)
6.	Xie, Songqiang: 6 articles (10/2021 - 02/2017)
7.	Wang, Chao-Jie: 5 articles (02/2021 - 07/2009)
8.	Wang, Chao-jie: 5 articles (07/2012 - 01/2009)
9.	Xie, Song-qiang: 5 articles (07/2012 - 01/2009)
10.	Zhu, Weiping: 4 articles (08/2022 - 03/2010)

Related Diseases

1.	Neoplasms (Cancer) 10/05/2021 - "Taken together, our study implies a promising strategy for naphthalimide conjugates to treat terminal cancer of HCC by targeting autophagy and tumor microenvironment with reduced toxicities and notable activities." 01/01/2021 - "In the present study, we synthesized a variety of B19 derivatives containing a known anti-cancer fluorescent chromophore naphthalimide for the purpose of enhancing anti-cancer activity. " 11/16/2023 - "The anticancer properties of the naphthalimide derivatives allow them to target a number of cancer cell lines. " 01/01/2021 - "Naphthalimide-phenanthroimidazole incorporated new fluorescent sensor for "turn-on" Cu2+ detection in living cancer cells." 01/01/2018 - "After oxidation, this method offers an efficient approach for the synthesis of substituted naphthalimides, which showed potent cytotoxic activity against HT-29 human cancer cell line."
2.	Carcinoma (Carcinomatosis) 01/01/2020 - "Our study implies a promising strategy for naphthalimide conjugates to treat hepatic carcinoma with notable activities and reduced toxicities at a low dosage." 11/01/2009 - "The current study was designed to precisely dissect the signaling pathway(s) responsible for the naphthalimide-induced cell cycle arrest in human colon carcinoma HCT116 cells. " 08/01/2019 - "UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway." 08/01/2019 - "Purpose: Studies have determined that UNBS5162, recognized as a new naphthalimide, holds inhibitory effects in prostate and breast tumors; however, its functional implication on gastric carcinoma is currently undetermined. " 10/05/2021 - "A naphthalimide-polyamine conjugate preferentially accumulates in hepatic carcinoma metastases as a lysosome-targeted antimetastatic agent."
3.	Breast Neoplasms (Breast Cancer) 01/01/2020 - "A novel naphthalimide that selectively targets breast cancer via the arylhydrocarbon receptor pathway." 01/01/2020 - "In addition, the higher therapeutic indices of 10b for 4T1 cells in vivo indicated that naphthalimide-Pt(IV) conjugates behaved a vital function in the treatment of breast cancer. " 01/15/2022 - "Under the stimulation by cellular hypochlorous acid (HClO) and visible light, selective release of active naphthalimide can be achieved within breast cancer cell lines, the release process of which can be tracked visually using near-infrared fluorescence of MB (685 nm). " 01/15/2022 - "Biotinylated curcumin as a novel chemosensitizer enhances naphthalimide-induced autophagic cell death in breast cancer cells." 01/01/2020 - "We report that the naphthalimide analogue 2-(2-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (NAP-6) is a highly potent and selective breast cancer targeting molecule. "
4.	Melanoma (Melanoma, Malignant) 12/16/2013 - "Recently, we have demonstrated the cytotoxic effect of a series of naphthalimide derivatives against B16F10 melanoma cells. " 08/01/2011 - "Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics." 08/01/2011 - "The nitro substituted naphthalimide-ITC derivative 3d was found to be the most effective in inducing apoptosis, and in inhibiting melanoma cell and tumor growth." 01/01/2017 - "Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma." 01/01/2019 - "In this study, the effects of naphthalimides UNBS5162 and amonafide on the properties of proliferation and apoptosis in human melanoma cells were confirmed. "
5.	Diabetic Neuropathies (Diabetic Neuropathy) 04/01/2009 - "The present study investigated whether combination of resveratrol and 4-amino 1,8 naphthalimide (4-ANI) is effective in the development of diabetic neuropathy (DN). " 04/01/2009 - "Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changes."

Related Drugs and Biologics

1.	Polyamines
2.	isoquinoline
3.	Cisplatin (Platino)
4.	Resveratrol
5.	Fluorescent Dyes (Fluorescent Probes)
6.	bisnafide
7.	Peptides (Polypeptides)
8.	Iridium
9.	Hydrogen Sulfide (Sulfide, Hydrogen)
10.	Estrogens (Estrogen)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Photochemotherapy (Photodynamic Therapy)
3.	Therapeutics