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Janus Kinase 2

A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
Also Known As:
JAK-2 Protein Tyrosine Kinase; JAK2 Protein Tyrosine Kinase; JAK 2 Protein Tyrosine Kinase
Networked: 325 relevant articles (8 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Verstovsek, Srdan: 13 articles (12/2013 - 11/2005)
2. Tefferi, Ayalew: 10 articles (04/2015 - 08/2005)
3. Vainchenker, William: 7 articles (08/2013 - 06/2006)
4. Prchal, Josef T: 6 articles (07/2015 - 11/2005)
5. Cazzola, Mario: 6 articles (06/2014 - 11/2005)
6. Kralovics, Robert: 5 articles (06/2014 - 11/2005)
7. Funakoshi-Tago, Megumi: 5 articles (11/2013 - 05/2011)
8. Green, Anthony R: 4 articles (02/2015 - 10/2009)
9. Guglielmelli, Paola: 4 articles (02/2015 - 08/2009)
10. Barbui, Tiziano: 4 articles (02/2015 - 08/2007)

Related Diseases

1. Neoplasms (Cancer)
2. Primary Myelofibrosis (Myelosclerosis)
3. Ischemia
4. Myeloproliferative Disorders (Myeloproliferative Disorder)
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. INCB018424
2. Messenger RNA (mRNA)
3. P-Glycoprotein
4. multidrug resistance-associated protein 1
5. Phosphotransferases (Kinase)
6. Protein-Tyrosine Kinases (Tyrosine Kinase)
7. STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
8. Interleukin-6 (Interleukin 6)
9. Leptin
10. Protein Kinases (Protein Kinase)

Related Therapies and Procedures

1. Stem Cell Transplantation
2. Heterologous Transplantation (Xenotransplantation)
3. Electroacupuncture
4. Liver Transplantation
5. Transplantation (Transplant Recipients)