Lethargy

A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simple tasks. It may be related to DEPRESSION or DRUG ADDICTION.

Networked: 838 relevant articles (34 outcomes, 28 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Fatigue
2.	Vomiting
3.	Ataxia (Dyssynergia)
4.	Seizures (Seizure)
5.	Muscle Hypotonia (Hypotonia)

Experts

1.	Li, B U K: 4 articles (07/2015 - 08/2003)
2.	Adams, Kathleen: 4 articles (03/2006 - 08/2003)
3.	Boles, Richard G: 4 articles (03/2006 - 08/2003)
4.	Klein-Schwartz, Wendy: 3 articles (05/2014 - 01/2005)
5.	Mohammadi, Mohammad-Reza: 3 articles (12/2013 - 02/2010)
6.	Akhondzadeh, Shahin: 3 articles (12/2013 - 02/2010)
7.	Harden, Lois M: 3 articles (06/2011 - 03/2009)
8.	Travison, Thomas G: 3 articles (10/2008 - 11/2007)
9.	Araujo, Andre B: 3 articles (10/2008 - 11/2007)
10.	Williams, Rachel E: 3 articles (10/2008 - 11/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lethargy:

1.	CreatinineIBA 01/01/2013 - "After adjustment for covariates, higher creatinine-corrected urinary concentrations of diethylphosphate metabolites were associated with improved attention and reduced lethargy and hypotonia in young infants. " 04/21/1993 - "Treatment was discontinued in 28 patients because of dose-limiting toxicity consisting of a syndrome of malaise, fatigue, and lethargy; recurrent reduction in creatinine clearance of 50% or more; or axonal neuropathy. " 07/01/2007 - "In contrast, at the dose of 150 mg/kg, adverse events such as lethargy, weight loss, and elevated BUN (p < 0.01) and serum creatinine (p < 0.001) levels were recorded. " 01/01/1991 - "Severe confusion and lethargy associated with rising creatinine developed in 2 patients. " 08/01/2006 - "All cats with chronic renal failure diagnosed on the basis of case histories, clinical signs (such as, lethargy, anorexia, loss of bodyweight and vomiting) and a high plasma creatinine (>180 micromol/l) were included in the study. "
2.	Phenobarbital (Luminal)FDA Link 05/01/2012 - "Ataxia, lethargy, and polydipsia were greater at 1 month for phenobarbital-treated dogs; vomiting was greater for bromide-treated dogs at 1 month and study end. " 07/01/1990 - "A 28-day-old infant developed lethargy, hypotonia, and hypothermia following a phenobarbital overdose secondary to a pharmacist's error. " 10/01/1977 - "A placebo-controlled, randomized, double-blind, parallel group study in hospital and general practice has shown that a combination of belladonna alkaloids, ergotamine tartrate, and phenobarbitone (Bellergal) was effective in treating troublesome symptoms of the premenstrual syndrome of which fatigue, tender breasts, nervousness, irritability, lethargy and listlessness were improved to a statistically significant degree. "
3.	Glucose (Dextrose)FDA LinkGeneric 09/01/2011 - "•  Adverse interactions include the blunting of thiazide effects by nonsteroidal anti-inflammatory drugs and the potential to increase fatigue, lethargy, and increase in glucose when combined with β-blockers. " 01/01/1985 - "Reductions of plasma glucose from 7.7 mM (control) to 2.5-1.7 mM (moderate hypoglycemia associated with decreased motor activity) or 1.5 mM (severe hypoglycemia with lethargy progressing to stupor) decreased glucose concentrations in the cerebral cortex, striatum, and hippocampus to less than 10% of control. " 01/01/2015 - "Hypoglycaemia caused characteristic behavioural alterations including lethargy, dullness, sitting quietly but appearing alert, followed by aesthesia and then muscular weakness with characteristic postural changes starting from drooping of head and torticollis, Rabbits recovered following glucose therapy. " 12/01/2005 - "They were chosen because clinical suspicion of infection was increased because of either patient signs and symptoms (fever, stiff neck, lethargy, worsening neurological examination) or preliminary laboratory analysis of CSF data (increased white blood cell count, increased protein level, decreased glucose). " 09/11/2004 - "In comparison with 1993-1994, there were less frequent lethargy or dehydration; lower average serum-glucose values, a better blood pH and less frequent ketonuria at the time of diagnosis. "
4.	Vitamin DFDA LinkGeneric 01/01/2007 - "Although the toxicity of vitamin D has conventionally been attributed to its induction of hypercalcemia, animal studies show that the toxic endpoints observed in response to hypervitaminosis D such as anorexia, lethargy, growth retardation, bone resorption, soft tissue calcification, and death can be dissociated from the hypercalcemia that usually accompanies them, demanding that an alternative explanation for the mechanism of vitamin D toxicity be developed. " 12/01/2009 - "We retrospectively studied seven children (six girls, one boy) aged from 7.5 to 25 months who presented to our institution after taking large doses of vitamin D (900 000-4 000 000 U) prescribed by medical practitioners for wrong indications like failure to thrive, etc. The clinical manifestations were constipation, decreased appetite, lethargy, polyuria, dehydration and failure to thrive. " 11/01/2007 - "We report on a case of severe hypercalcemia due to vitamin D intoxication in a 4-month-old infant, A 4-month-old boy was admitted for anorexia, weakness, hypotonia, constipation and lethargy. " 11/01/2007 - "When faced with an infant presenting with digestive disorders such as vomiting and constipation, associated with neurological troubles (lethargy, hypotonia) and hypercalcemia, vitamin D intoxication should be considered after tumoral, hormonal or malformative (Williams-Beuren syndrome) causes have been eliminated. " 02/01/2003 - "Vitamin D-dependent rickets type 2 in a four-month-old cat A 4-month-old male domestic shorthair cat was examined because of lethargy, vomiting, diarrhea, muscle tremors, and mydriasis. "
5.	Propranolol (Inderal)FDA LinkGeneric 02/01/1987 - "Withdrawal from the trial because of lethargy and fatigue was significantly greater among patients on methyldopa and propranolol than among those receiving captopril. "
6.	Methyldopa (Aldomet)FDA LinkGeneric 02/01/1987 - "Withdrawal from the trial because of lethargy and fatigue was significantly greater among patients on methyldopa and propranolol than among those receiving captopril. "
7.	Ergotamine (Ergotamine Tartrate)FDA LinkGeneric 10/01/1977 - "A placebo-controlled, randomized, double-blind, parallel group study in hospital and general practice has shown that a combination of belladonna alkaloids, ergotamine tartrate, and phenobarbitone (Bellergal) was effective in treating troublesome symptoms of the premenstrual syndrome of which fatigue, tender breasts, nervousness, irritability, lethargy and listlessness were improved to a statistically significant degree. "
8.	CurcuminIBA 01/01/2003 - "In this study, we demonstrate that diferuloylmethane exerts protective effect in high-dose endotoxin shock by improving survival and reducing the severity of endotoxin shock symptoms such as lethargy, diarrhea, and watery eyes following a challenge with lipopolysaccharide. "
9.	Captopril (Capoten)FDA LinkGeneric 02/01/1987 - "Withdrawal from the trial because of lethargy and fatigue was significantly greater among patients on methyldopa and propranolol than among those receiving captopril. "
10.	Belladonna AlkaloidsIBA 10/01/1977 - "A placebo-controlled, randomized, double-blind, parallel group study in hospital and general practice has shown that a combination of belladonna alkaloids, ergotamine tartrate, and phenobarbitone (Bellergal) was effective in treating troublesome symptoms of the premenstrual syndrome of which fatigue, tender breasts, nervousness, irritability, lethargy and listlessness were improved to a statistically significant degree. "

Therapies and Procedures

1.	Aftercare (After-Treatment) 01/01/2015 - "After treatment, neck masses persisted in 48.4% of patients and complaints of lethargy and fever in 6.5%. " 11/01/2006 - "After treatment, 8 of the 12 pigeons exhibited signs of anorexia, lethargy, and dehydration; these birds died within 2 d after the onset of clinical signs. " 06/15/2006 - "CASE DESCRIPTION-A 12-week-old female English Springer Spaniel was evaluated for lethargy, vomiting, and pyrexia 1 week after treatment of patent ductus arteriosus (PDA) via coil occlusion. " 03/01/2013 - "In the other patients after treatment, the symptoms such as recurrent vomiting, seizures, lethargy, and poor feeding disappeared, muscle strength and muscle tension were improved, and general biochemical abnormalities such as anemia and metabolic acidosis were corrected. " 03/01/2014 - "CAF induced inflammatory gene expression - IL-1R1 (p<0.001), IL-6 (p<0.01), TNFα (p<0.01), and MCP-1 (p<0.05) - in the rodent hypothalamus 6-24h after treatment during maximum fatigue/lethargy. "
2.	Injections 07/01/1993 - "The seroconversion rates measured by ELISA were 98.3% (59/60) at months 1 and 6 and 100% at month 7. Sixty-one per cent (109/180) of the documented injections were followed by local symptoms, essentially mild soreness at the site of injection; and 22.2% (40/180) by minor general symptoms including malaise, fatigue and lethargy. " 07/01/1982 - "After i.c.v. injections, the low frequency EEG during the lethargy and ataxia were not evident. " 10/15/1993 - "After the injections were abruptly discontinued, the horse developed anorexia, lethargy, weight loss, and bilateral forelimb lameness. " 11/13/2002 - "The pyrithiamine-injections induced several M74-like symptoms including incoordination, lethargy, whitened liver and yolk-sac precipitates. " 03/01/1978 - "Glucose and insulin injections given during lethargy showed no effects on plasma insulin and glucose respectively but confirmed a very low plasma clearance of glucose and insulin. "
3.	Arthroplasty 04/15/2006 - "There was 1 case of cup reinsertion in group 1 because of large anteversion angle; 2 cases of symptomatic DVT and 1 case of lethargy because of cerebral infarction happened in group 2. Minimally invasive total hip arthroplasty using anterior approach is a safe and effective technique with the advantages of less soft tissue damage and less blood loss." 04/01/2010 - "We report a case of Staphylococcus aureus sepsis after total shoulder arthroplasty in a patient who presented to her surgeon 8 days postoperatively with lethargy and labored breathing. "
4.	Preoperative Period 12/01/2007 - "In the preoperative period, all patients showed lethargy and cognitive deficit, both of which were eradicated after LDLT in all surviving patients. "
5.	Continuous Positive Airway Pressure 08/01/1987 - "Continuous positive airway pressure and administration of medroxyprogesterone acetate prevented further episodes and relieved much of the somnolence and lethargy that had contributed to the evidence for myxedema. "