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Myeloid Differentiation Factor 88

An intracellular signaling adaptor protein that plays a role in TOLL-LIKE RECEPTOR and INTERLEUKIN 1 RECEPTORS signal transduction. It forms a signaling complex with the activated cell surface receptors and members of the IRAK KINASES.
Also Known As:
MyD88 Protein; TLR Signal Adaptor Protein MyD88; Toll-Like Receptor Signal Adaptor Protein MyD88; Toll Like Receptor Signal Adaptor Protein MyD88
Networked: 126 relevant articles (3 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Akira, Shizuo: 11 articles (10/2011 - 10/2002)
2. Erard, François: 4 articles (02/2010 - 04/2004)
3. Ryffel, Bernhard: 4 articles (02/2010 - 04/2004)
4. Takeda, Kiyoshi: 3 articles (08/2005 - 12/2003)
5. Ropert, Catherine: 3 articles (10/2004 - 01/2004)
6. Lin, Fei: 2 articles (04/2015 - 02/2015)
7. Li, Wei: 2 articles (04/2015 - 02/2015)
8. Pan, Linghui: 2 articles (04/2015 - 02/2015)
9. Yu, L: 2 articles (02/2015 - 05/2014)
10. Holzmann, Bernhard: 2 articles (02/2014 - 09/2002)

Related Diseases

1. Infection
2. Inflammation
3. Necrosis
12/01/2014 - "Myeloid differentiation factor 88 (MyD88) and Tumour necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) are key molecules in this signalling pathway. "
12/01/2007 - "Acute bronchoconstriction, tumour necrosis factor (TNF), interleukin (IL)-12 and keratinocyte-derived chemokine (KC) production, protein leak and neutrophil recruitment in the lung are abrogated in mice deficient for the adaptor molecules myeloid differentiation factor 88 (MyD88) and Toll/Interleukin-1 receptor (TIR)-domain-containing adaptor protein (TIRAP), but independent of TIR-domain-containing adaptor-inducing interferon-beta (TRIF). "
01/01/2014 - "The mRNA expression abundances of peroxisome proliferator-activated receptor coactivator-1α (PGC-1α), TLR4, myeloid differentiation factor 88 (MyD88), tumour necrosis factor-α (TNF-α), interleukin 6 (IL-6) and IL-1 receptor antagonist (IL-1Rn) were significantly affected by HF feeding, and IL-6 and IL-1Rn mRNA expressions were up-regulated in IUGR pigs compared with NBW pigs. "
02/15/2015 - "Our study shows that the VCC oligomers assembled in the liposome membranes elicit potent proinflammatory responses in monocytes and macrophages, via stimulation of the toll-like receptor (TLR)2/TLR6-dependent signalling cascades that involve myeloid differentiation factor 88 (MyD88)/interleukin-1-receptor-associated kinase (IRAK)1/tumour-necrosis-factor-receptor-associated factor (TRAF)6. VCC oligomer-mediated proinflammatory responses critically depend on the activation of the transcription factor nuclear factor-κB. "
02/01/2008 - "Our objective was to determine the effects of glutamine (Gln) on Toll-like receptor 4 (TLR-4), myeloid differentiation factor 88 (Myd88) and tumour necrosis factor (TNF)-alpha receptor-associated factor 6 (TRAF6) expression in intestinal mucosa following LPS endotoxaemia in a rat. "
4. Yersinia Infections
5. Herpes Genitalis (Genital Herpes)

Related Drugs and Biologics

1. Toll-Like Receptors (Toll-Like Receptor)
2. Interleukin-6 (Interleukin 6)
3. Interleukins
4. Collagen
5. dioscin
6. NF-kappa B (NF-kB)
7. Cytokines
8. Toll-Like Receptor 2
9. Messenger RNA (mRNA)
10. Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1. Stem Cell Transplantation
2. Transplants (Transplant)
3. Moxibustion