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Keratin-15 (Keratin 15)

A type I keratin found in the basal layer of the adult epidermis and in other stratified epithelia.
Also Known As:
Keratin 15; Cytokeratin-15; Cytokeratin 15
Networked: 33 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Mahalingam, Meera: 4 articles (08/2012 - 05/2010)
2. Hoang, Mai P: 3 articles (08/2012 - 05/2010)
3. Richards, Joanna E: 3 articles (08/2012 - 05/2010)
4. Cotsarelis, George: 2 articles (10/2013 - 08/2003)
5. Muzikansky, Alona: 2 articles (08/2012 - 05/2010)
6. Murphy, George F: 2 articles (06/2012 - 09/2003)
7. Korngold, Robert: 2 articles (06/2012 - 09/2003)
8. Misago, Noriyuki: 2 articles (09/2006 - 01/2006)
9. Narisawa, Yutaka: 2 articles (09/2006 - 01/2006)
10. Pirasteh, Hamid Reza: 1 article (05/2015)

Related Diseases

1. Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/01/2011 - "For cytokeratin-15, expression was retained in actinic keratosis (38%), squamous cell carcinoma in situ (53%) and bowenoid papulosis (60%) but appeared to be lost in squamous cell carcinoma (3%) with statistically significant differences observed between groups that retained versus those that did not (P<0.05 for all three); for cytokeratin-19, patchy yet basal expression was noted in actinic keratosis (21%), patchy and suprabasal expression was noted in squamous cell carcinoma in situ (37%), bowenoid papulosis (13%) and squamous cell carcinoma (24%) with no statistically significant differences between groups; for p63, expression was retained in actinic keratosis (90%), squamous cell carcinoma in situ (87%), bowenoid papulosis (60%) and squamous cell carcinoma (100%) with no statistically significant differences between groups. "
01/01/2011 - "In this study, we evaluate expression of cytokeratin-15, cytokeratin-19, and p63 in a series of primary cutaneous epithelial lesions that include actinic keratosis (n=29), squamous cell carcinoma in situ (n=30), bowenoid papulosis (n=15) and squamous cell carcinoma, well differentiated (n=29) in order to evaluate the role of stem cell marker expression in the grading and development of in situ and invasive malignancies. "
08/01/2012 - "In this study, we assessed immunohistochemical expression of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in 67 cases (39 porocarcinomas and 28 moderately differentiated squamous cell carcinomas) to determine their use as histologic adjuncts. "
08/01/2012 - "An immunohistochemical comparison of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in differentiating porocarcinoma from squamous cell carcinoma."
09/01/2003 - "Immunohistochemical reactivity (number positive/number of cases tested [percent positive], frequency of staining) included keratin 14 (31/64 [48%], variable), gamma-catenin (35/74 [47%], variable), keratin 5/6 (10/33 [30%], focal), calretinin (8/40 [20%], focal), keratin 20 (11/71 [15%], focal), p63 (3/20 [15%], focal), whereas 9 invasive cutaneous squamous cell carcinomas showed strong p63 positivity, epithelial-specific antigen (10/74 [14%], variable), CD117/Kit (5/37 [14%], focal), keratin 15 (3/23 [13%], rare cell), mesothelin (2/64 [3%], rare cell), and CD10 (1/41 [2%], rare cell). "
2. Basal Cell Carcinoma (Rodent Ulcer)
3. Cicatrix (Scar)
4. Alopecia (Baldness)
5. Actinic Keratosis

Related Drugs and Biologics

1. Keratin-19 (Keratin 19)
2. nestin (nestin protein)
3. Keratin-7 (Cytokeratin 7)
4. Carcinoembryonic Antigen
5. N 30
6. Keratin-20 (Cytokeratin 20)
7. calretinin
8. Keratin-5 (Keratin 5)
9. Keratin-14 (Keratin 14)
10. Keratin-17 (Keratin 17)

Related Therapies and Procedures

1. Stem Cell Transplantation