Keratin-5 (Keratin 5)

A type II keratin that is found associated with the KERATIN-14 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-5 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.

Also Known As:

Networked: 629 relevant articles (9 outcomes, 58 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Akslen, Lars A: 9 articles (01/2017 - 10/2003)
2.	Moran, Cesar A: 8 articles (01/2019 - 07/2011)
3.	Foulkes, William D: 7 articles (01/2017 - 10/2003)
4.	Ordóñez, Nelson G: 7 articles (07/2014 - 08/2003)
5.	Magin, Thomas M: 6 articles (01/2020 - 03/2006)
6.	Stefansson, Ingunn M: 6 articles (01/2017 - 10/2003)
7.	Weissferdt, Annikka: 6 articles (07/2016 - 07/2011)
8.	Sartorius, Carol A: 5 articles (01/2020 - 07/2011)
9.	Sawamura, Daisuke: 5 articles (08/2018 - 06/2002)
10.	Wang, Xiao-Jing: 5 articles (12/2014 - 04/2004)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2010 - "In this study, based on immunostaining for HMW Cytokeratin 5 (normally present in normal breast cells and absent in malignant cells) on conventional breast nodules aspirates, 21 out of 30 evaluated cases diagnosed as "C3" and with histological control, have been reclassified as "C2", Benign or "C4", Suspicious of malignancy. " 01/01/2006 - "To study the role of E2F3 in tumor development, we established a transgenic mouse model expressing E2F3a in a number of epithelial tissues via a keratin 5 (K5) promoter. " 04/01/2021 - "Ki-67 and cytokeratin 5/6-positive breast cancers showed higher Emax/Efat ratios (P<0.05). " 10/01/2020 - "Case 2 displayed more marked cellular atypia than Case 1. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin 5/6, p63/p40, SRY-related HMG-box 10 and Ki-67, but negative for other myoepithelial markers and p16. " 01/01/2020 - "In exploratory analyses, basal-like tumors, could be identified by keratin 5, were more hypoxic and enriched for a T-cell-inflamed gene expression signature. "
2.	Carcinoma (Carcinomatosis) 01/01/2017 - "In this study, we determined the rate of cytokeratin 5/6-positive cells in primary high-grade serous carcinoma. " 05/01/2022 - "We assess the utility of cytokeratin 5/6 (CK5/6) and GATA-3 immunohistochemistry in distinguishing condyloma acuminatum from non-invasive papillary urothelial carcinoma. " 05/01/2022 - "Utility of GATA-3 and Cytokeratin 5/6 Immunostains in Separating Condyloma Acuminatum Arising in the Urinary Tract From Non-Invasive Papillary Urothelial Carcinoma." 03/01/2018 - "Undifferentiated (or lymphoepithelial-like) carcinomas of the oropharynx are more frequently p40 or cytokeratin 5/6 negative or show only weak or focal expression. " 03/01/2016 - "[Metaplastic carcinoma of the breast and the impact of the p63 and cytokeratin 5/6: experience of 40 patients]."
3.	Adenocarcinoma 11/01/2012 - "In addition, anterior gradient homolog 2 and MUC5AC are useful positive markers of adenocarcinoma in the setting of absent or diminished p63 and cytokeratin 5/6 staining." 08/01/2007 - "Neoplastic basal cells and less-differentiated adenocarcinoma cells, which were identifiable by immunolabelling for cytokeratin 5 (CK5) and CK18, were considered to be pluripotential. " 08/26/2020 - "In the following study, we examined the combination of cytokeratin 5/6, p63, p40 and MUC5AC for distinguishing squamous cell carcinoma (SCC) from adenocarcinoma of the cervix (AEC). " 12/01/2009 - "The purpose of this study was to determine whether SOX2 is differentially expressed in squamous cell carcinomas versus adenocarcinomas of the esophagus and rectum/anal canal and to compare its expression to p63, cytokeratin 5/6, and CDX2. " 08/01/1997 - "Previous studies using frozen material have suggested that cytokeratin 5 is expressed by pleural mesothelioma but not by adenocarcinoma. "
4.	Mesothelioma 01/01/2017 - "For histopathologic differentiation from mesothelioma cytokeratin, 5/6 immunohistochemistry is widely used. " 08/01/2008 - "Cytokeratin 5/6 staining was also present in 33/34 (97%) of mesothelioma cases. " 06/01/2002 - "Cytokeratin 5/6 antibody, which recently became commercially available, has been found useful in the diagnosis of mesothelioma. " 08/01/1997 - "Anti-cytokeratin 5/6: a positive marker for epithelioid mesothelioma." 01/01/1989 - "Expression of keratin 5 as a distinctive feature of epithelial and biphasic mesotheliomas. "
5.	Noninfiltrating Intraductal Carcinoma (DCIS) 07/01/2006 - "Recent studies have demonstrated that immunohistochemical staining for cytokeratin 5/6 can distinguish UDH from conventional forms of ductal carcinoma in situ. " 05/01/2013 - "The immunohistochemical expression of cytokeratin 5/6 by ductal carcinoma in situ epithelial cells may provide clinically useful information regarding the risk of progression to invasive disease." 05/01/2013 - "In the low-grade ductal carcinoma in situ subgroup, only cytokeratin 5/6 expression exhibited a negative association with the probability of invasion. " 02/01/2007 - "A total of 245 pure ductal carcinoma in situ cases from a population-based, case-control study were evaluated for histologic characteristics and immunostained for ER, HER2/neu, EGFR, cytokeratin 5/6, p53, and Ki-67. " 07/01/2006 - "We conclude that the absence of strong cytokeratin 5/6 expression by SP-DCIS distinguishes it from its morphological mimic, UDH. "

Related Drugs and Biologics

1.	Antibodies
2.	Calbindin 2
3.	Estrogen Receptors
4.	Keratins (Keratin)
5.	Keratin-7 (Cytokeratin 7)
6.	Phenobarbital (Luminal)
7.	Proteins (Proteins, Gene)
8.	Keratin-14 (Keratin 14)
9.	Amino Acids
10.	Surface-Active Agents (Surfactants)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Neoadjuvant Therapy
4.	Adjuvant Chemotherapy