Keratin-6 (Keratin 6A)

A type II keratin found associated with KERATIN-16 or KERATIN-17 in rapidly proliferating squamous epithelial tissue. Mutations in gene for keratin-6A and keratin-6B have been associated with PACHYONYCHIA CONGENITA, TYPE 1 and PACHYONYCHIA CONGENITA, TYPE 2 respectively.

Also Known As:

Networked: 94 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Garrett, Scott H: 4 articles (01/2017 - 04/2008)
2.	Sens, Donald A: 4 articles (01/2017 - 04/2008)
3.	Sens, Mary Ann: 4 articles (01/2017 - 04/2008)
4.	Somji, Seema: 4 articles (01/2017 - 04/2008)
5.	Zhou, Xu Dong: 4 articles (01/2017 - 04/2008)
6.	McLean, W H Irwin: 3 articles (12/2017 - 03/2008)
7.	Smith, Frances J D: 3 articles (12/2017 - 03/2008)
8.	Li, Yi: 3 articles (01/2016 - 12/2003)
9.	Dang, Erle: 2 articles (01/2022 - 10/2017)
10.	Wang, Gang: 2 articles (01/2022 - 10/2017)

Related Diseases

1.	Pachyonychia Congenita (Jadassohn-Lewandowsky Syndrome) 03/01/2021 - "Homozygous dominant missense mutation in Keratin 6b leading to severe pachyonychia congenita." 12/01/2017 - "Keratin 6b variant p.Gly499Ser reported in delayed-onset pachyonychia congenita is a non-pathogenic polymorphism." 07/01/2015 - "A novel H1 mutation in keratin 6a in an infant with pachyonychia congenita." 01/01/2014 - "Delayed-onset pachyonychia congenita caused by a novel mutation in the V2 domain of keratin 6b." 05/01/2011 - "Pachyonychia congenita (PC) is a keratinizing disorder predominantly caused by mutations in keratin 6a (K6a) (∼50% of cases) or K6b, K16, or K17. "
2.	Neoplasms (Cancer) 12/01/2011 - "The present results, coupled with previous studies, indicate that malignant transformation of UROtsa cells by Cd(+2) or As(+3) produce similar patterns of keratin 6, 7, 16, 17, and 19 in the resulting series of cell lines and their respective tumors." 01/01/2020 - "Moreover, keratin 6A hyperexpression was positively correlated with lymph node positive and aggressive tumor T stage. " 01/01/2016 - "To examine how different initiating oncogenes drive tumor phenotype, we somatically delivered two oncogenes (ErbB2, PyMT) into a narrow and distinct subset of the mouse mammary epithelium defined by the expression of the progenitor marker keratin 6a (Krt6a), and compared the phenotypes of the resulting mammary tumors. " 12/01/2011 - "The expression of keratin 6, 16, and 17 was also correlated with areas of the urothelial tumor cells that had undergone squamous differentiation. " 06/01/2009 - "The GLI1-induced tumors are histologically heterogeneous and involve the expansion of a population of epithelial cells expressing the progenitor cell markers keratin 6 and Bmi-1. "
3.	Carcinogenesis 08/29/2014 - "Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch." 05/01/1994 - "In order to investigate the role of papillomavirus early gene expression in epithelial oncogenesis in vivo, we produced transgenic mice expressing HPV-16 early region genes from the promoter of the bovine keratin 6 gene. " 08/29/2014 - "To direct ODC expression in distinct epidermal compartments, we have developed keratin 6 (K6)-ODC/SKH-1 and keratin 14 (K14)-ODC/SKH-1 mice and employed them to investigate the role of ODC directed to these epidermal compartments on UVB-induced carcinogenesis. " 10/01/2023 - "In S6-treated lesions, Keratin 6 and Keratin 8 were less expressed, EMT was less advanced, with a higher E-cadherin/Vimentin ratio, indicating a delayed carcinogenesis when SIRT6 was inhibited. " 08/15/2001 - "To directly evaluate the role of increased ornithine decarboxylase (ODC) and polyamines in mouse skin carcinogenesis, we used bovine keratin 5 (K5) and keratin 6 (K6) promoter elements to direct the expression of antizyme (AZ) to specific skin cell populations. "
4.	Neoplasm Metastasis (Metastasis) 05/01/2019 - "Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade." 01/01/2020 - "In conclusion, current study suggests that hyperexpressed keratin 6A in lung adenocarcinoma promotes lung cancer proliferation and metastasis via epithelial-mesenchymal transition and cancer stem cells transformation." 02/01/2008 - "In addition, we found that, like their primary tumors, lung metastases in Wnt-1 transgenic mice harbor both epithelial and myoepithelial tumor cells and cells that express the putative progenitor cell marker keratin 6. Our data suggest that both gene expression profiles and cellular heterogeneity are preserved after breast cancer has spread to distant sites, and that metastases are similar to each other when their primary tumors were induced by the same oncogene and from the same subset of mammary cells."
5.	Cicatrix (Scar) 09/27/2023 - "In this study, we examined the expression pattern and distribution of cytokeratin 6a (CK6a) in healthy human skin samples of different body locations, in fetal and scar skin samples, as well as in dermo-epidermal skin substitutes (DESSs). " 12/01/2015 - "Despite healing acceleration, epidermal remodelling was delayed in the scars of Itch(-/-) mice, as indicated by enhanced epidermal thickening, keratinocyte proliferation and keratin 6 expression, and retarded keratin 14 polarization to the basal layer. "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	arsenite
3.	Spermine
4.	Spermidine
5.	anthracene
6.	Proteins (Proteins, Gene)
7.	Keratins (Keratin)
8.	Keratin-10
9.	Keratin-16 (Keratin 16)
10.	Keratin-17 (Keratin 17)

Related Therapies and Procedures

1.	Therapeutics
2.	Artificial Skin