Keratin-10

A type I keratin that is found associated with the KERATIN-1 in terminally differentiated epidermal cells such as those that form the stratum corneum. Mutations in the genes that encode keratin-10 have been associated with HYPERKERATOSIS, EPIDERMOLYTIC.

Also Known As:

Networked: 126 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Choate, Keith A: 3 articles (05/2016 - 04/2015)
2.	Akiyama, Masashi: 3 articles (07/2008 - 12/2004)
3.	Shimizu, Hiroshi: 3 articles (07/2008 - 12/2004)
4.	Paller, Amy S: 2 articles (01/2022 - 04/2015)
5.	He, W F: 2 articles (10/2020 - 10/2020)
6.	Burger, Bettina: 2 articles (12/2019 - 01/2015)
7.	Itin, Peter H: 2 articles (12/2019 - 01/2015)
8.	Reichelt, Julia: 2 articles (12/2019 - 11/2004)
9.	Spoerri, Iris: 2 articles (12/2019 - 01/2015)
10.	van Erp, Piet E J: 2 articles (01/2018 - 01/2005)

Related Diseases

1.	Epidermolytic Hyperkeratosis (Bullous Congenital Ichthyosiform Erythroderma) 03/01/2018 - "Recessive epidermolytic ichthyosis results from loss of keratin 10 expression, regardless of the mutation location." 01/01/2018 - "A novel Y160C mutation of Keratin 10 gene in a Chinese male infant with epidermolytic hyperkeratosis. " 01/01/2018 - "A novel Y160C mutation of Keratin 10 gene in a Chinese male infant with epidermolytic hyperkeratosis." 10/01/2016 - "S159P mutation of keratin 10 gene causes severe form of epidermolytic hyperkeratosis." 04/01/2016 - "Mutations in the keratin 10 gene (KRT10) have been shown to underlie several forms of epidermolytic ichthyosis (EI), including generalized, annular and naevoid variants. "
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 09/01/2014 - "A unique proteomic profiling with abnormal expression of alpha-1 antitrypsin and presence of keratin 10 in sera of psoriasis patients were observed that may constitute new and useful findings of psoriasis and offer a clue to a better understanding of the inflammatory pathway." 01/01/2005 - "The number of Ki-67 positive nuclei and the percentage of keratin-10 positive epidermal cells in flexural and plaque psoriasis were comparable. " 07/01/2004 - "In addition to the increased keratin 10 expression in ILVEN sine psoriasis, T cells relevant in the pathogenesis of psoriasis are markedly reduced in ILVEN sine psoriasis as compared to psoriasis. " 07/01/2005 - "Furthermore, a marked decreased expression of keratin 10 was observed in psoriasis (41% of epidermal area) contrary to atopic dermatitis (70%). " 09/01/2014 - "Alpha-1 antitrypsin, retinol binding protein and keratin 10 alterations in patients with psoriasis vulgaris, a proteomic approach."
3.	Papilloma (Papillomatosis) 07/01/2001 - "However, alpha3beta1 transgenic papillomas displayed a diminished proliferative capacity and were more highly differentiated as judged by BrdUrd incorporation and keratin 10 expression, respectively, than alpha2beta1 transgenic and wild-type papillomas. " 06/01/2000 - "In this study, we added bovine papilloma virus 1 (BPV) DNA into expression vectors with the lacZ gene driven by metallothionein and keratin 10 promoters, and we transferred them into keratinocytes in vivo using the naked DNA method, and measured beta-gal activity in keratinocytes. "
4.	Bloom Syndrome 08/01/2002 - "A study of the keratin 10 deficient mouse, a model for epidermolytic hyperkeratosis, and a mouse model for Bloom syndrome are reviewed in this article. "
5.	Inflammation (Inflammations) 09/01/2010 - "The above findings suggest the following mechanism of events underlying KLK8/neuropsin-induced hyperkeratosis: (i) skin inflammation increases KLK8/neuropsin expression in the stratum spinosum; (ii) the released KLK8/neuropsin inhibits AP-2α expression in the cells of the stratum basale and stratum spinosum; (iii) the decrease in AP-2α results in cell proliferation in the stratum basale and cell differentiation in the stratum spinosum, with an increase in keratin 10 expression." 01/01/2018 - "A dose of only 1 × 105 freshly isolated, non expanded Treg injected intradermally in close proximity to the transplanted human skin prevented inflammation of the grafted tissue induced by 4 × 107 IP injected human allogeneic PBMCs, (ratio Treg:PBMC = 1:400), as indicated by the inhibition of epidermal thickening, sustained Keratin-10 expression, the absence of Keratin-16 up regulation and prevention of human CD3+ T cell influx. " 06/15/2019 - "Wound planimetry, histological examination, and biochemical and molecular methods of detecting factors of angiogenesis, inflammation, type I collagen, and keratin 10 and 14 were used to monitor wound healing. " 02/01/2000 - "Biopsies were taken from the treated lesion before treatment, after clearance and at relapse, and cells were analysed by flow cytometry with markers for differentiation (keratin 10), inflammation (vimentin), and proliferation (DNA content). " 08/01/2004 - "Significant reductions in Ki-67, keratin 16, transglutaminase, dermal CD4, epidermal CD8, and inflammation scores were seen after bexarotene treatment in combination with a significant increase in keratin 10. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Keratin-1
3.	Vimentin
4.	Metallothionein
5.	Betamethasone Valerate (Betamethasone 17 Valerate)
6.	calcipotriene (calcipotriol)
7.	clobetasone butyrate (Eumovate)
8.	Proteins (Proteins, Gene)
9.	involucrin
10.	Keratin-6 (Keratin 6A)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)