Keratin-14 (Keratin 14)

A type I keratin that is found associated with the KERATIN-5 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-14 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.

Also Known As:

Networked: 372 relevant articles (1 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Frazer, Ian H: 7 articles (01/2021 - 11/2004)
2.	Leggatt, Graham R: 5 articles (01/2021 - 11/2004)
3.	Detmar, Michael: 5 articles (11/2016 - 01/2003)
4.	Ewald, Andrew J: 4 articles (11/2020 - 12/2013)
5.	Magin, Thomas M: 4 articles (01/2020 - 08/2015)
6.	Lettner, Thomas: 4 articles (01/2018 - 12/2010)
7.	Mattarollo, Stephen R: 4 articles (01/2018 - 01/2013)
8.	Wally, Verena: 4 articles (01/2018 - 12/2010)
9.	Reis-Filho, Jorge S: 4 articles (10/2013 - 08/2003)
10.	Fischer, Susan M: 4 articles (08/2013 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 02/15/2009 - "To study its contribution to tumor development, we overexpressed the mutant or wild-type (WT) human beta1 subunit in the basal layer of mouse epidermis using the keratin 14 promoter. " 11/01/2023 - "In contrast, the clear tumor cells expressed several myoepithelial markers, including α-smooth muscle actin, p63, and cytokeratin 14. " 01/01/2023 - "Single cell sequencing analysis discovered Keratin 14 (KRT14, one of the seven anoikis-related genes) was mainly expressed in malignant cells in various cancers. " 05/01/2015 - "Analysis of human tumor specimens confirmed a significant relationship between loss of FOXA1 and increased cytokeratin 14 expression. " 02/01/2014 - "The tumors displayed an invasive growth, with positive expressions of 34betaE12, P63 and Cytokeratin 14, and negative expressions of PSA and P504s. "
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2005 - "To study the role of HCR in psoriasis, we engineered transgenic mice with either a HCR non-risk allele or the HCR *WWCC risk allele controlled by the cytokeratin 14 promoter. " 02/15/2014 - "In the current study, we assessed IL-37 in two well-known psoriasis models: a human keratinocyte cell line (HaCaT) and the keratin 14 VEGF-A-transgenic mouse model. " 01/01/2011 - "Transgenic mice over-expressing VEGF under the Keratin 14 (K14) promoter develop an inflammatory skin condition with many of the pathobiological features of human psoriasis. " 08/01/2008 - "Transgenic keratin 14 (K14)/vascular endothelial growth factor (VEGF) mice have previously been reported to develop a psoriasis-like phenotype. " 06/01/2004 - "The expression of amphiregulin (AR) in the basal epidermis of transgenic mice [keratin 14 promoter AR gene (K14-ARGE)] has been previously shown to induce an early-onset and severe skin pathology, with many similarities to psoriasis. "
3.	Wounds and Injuries (Trauma) 12/01/2022 - "Immunofluorescence staining for cytokeratin 14 showed that keratinocytes had migrated further across the wound in the uninfected samples treated by LAWS. " 06/01/2022 - "Importantly, type II diabetic mice (db/db mice) treated with the PU-adhesive-LL37 dressing for different periods of time (6 or 14 days) showed enhanced wound healing and re-epithelialization (i.e., high keratin 14/5 levels) and lower macrophage infiltration in the wounds compared to animals treated with PU. " 06/04/2009 - "Experiments performed in transgenic mice bearing HO-1 under control of keratin 14 promoter showed that increased level of HO-1 in keratinocytes is enough to improve the neovascularization and hasten the closure of wounds. " 11/01/2005 - "The expression of cytokeratin 14 suggested a myoepithelial origin but immunophenotypical profile, invasive and neoangiogenic potential of A17 cells and tumours showed many similarities with the reactive stroma that occurs in wound repair and in cancerogenesis. " 09/01/1999 - "Keratin 14 (K14) is believed to play a pivotal role in the maintenance of epidermal cell shape and contributing to their resistance to mechanical trauma, thereby protecting the cells from lysing. "
4.	Skin Diseases (Skin Disease) 06/01/2016 - "Altered expression of keratin 14 in lesional epidermis of autoimmune skin diseases." 01/01/2022 - "More than 107 pathogenic variations were identified in Keratin 14 gene (KRT14) in patients affected by epidermolysis bullosa simplex (EBS), a rare skin disease with still no curative treatment. " 07/15/2008 - "When we transferred autoreactive TCR-Tg CD8 T cells (OT-I cells), keratin 14 (K14)-mOVA(high) Tg mice developed autoreactive skin disease (graft-vs-host disease (GVHD)-like skin lesions) while K14-mOVA(low) Tg mice did not. " 09/01/2015 - "The aim of this study was to investigate the sun exposure influence on the DNA methylation profile on the matrix metalloprotease-9 (MMP9), microRNA 137 (miR-137), cytokeratin 14 (KRT14) and 19 (KRT19) genes of skin cells of subjects with no history of skin diseases. " 11/01/1998 - "Following from the observation that amphiregulin is overexpressed in lesional psoriatic epidermis, the importance of amphiregulin in hyperproliferative skin diseases has been further supported by recent studies of the targeted expression of a transgene encoding keratin 14 promoter-driven human amphiregulin to the basal epidermis of mice. "
5.	Cysts 04/01/2014 - "Three mice (2 male, 1 female; age, 5 to 16 mo) from a mouse line transgenic for keratin 14 (K14)-driven LacZ expression and on an outbred Crl:CD1(ICR) background, were identified as having distended abdomens and livers that were diffusely enlarged by numerous cysts (diameter, 0.1 to 2.0 cm). " 09/01/2016 - "This study is an attempt to identify if both epithelial (cytokeratin 14 [CK14]) and mesenchymal (vimentin) markers are expressed in the follicular and extrafollicular variants of AOT and to compare the expression with dentigerous cyst (DC) as this cyst is known to arise from reduced enamel epithelium which expressed CK14. " 01/01/2021 - "The aim of this study was to evaluate if the expression of amelogenin, cytokeratin AE1/AE3 (CKAE1/AE3) and cytokeratin 14 (CK14) in cysts and odontogenic tumors with calcified matrices such as calcifying odontogenic cyst (COC), compound (CdO) and complex (CxO) odontomas, adenomatoid odontogenic tumor (AOT) and calcifying epithelial odontogenic tumor (CEOT) as an aggressiveness indicator. "

Related Drugs and Biologics

1.	Keratin-5 (Keratin 5)
2.	Estrogen Receptors
3.	Amino Acids
4.	Vimentin
5.	Proteins (Proteins, Gene)
6.	Keratins (Keratin)
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	Cadherins (E-Cadherin)
9.	Keratin-19 (Keratin 19)
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Gingivectomy
3.	Drug Therapy (Chemotherapy)