Keratin-17 (Keratin 17)

A type I keratin found associated with KERATIN-6 in rapidly proliferating squamous epithelial tissue. Mutations in the gene for keratin-17 have been associated with PACHYONYCHIA CONGENITA, TYPE 2.

Also Known As:

Networked: 209 relevant articles (2 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Gang: 15 articles (01/2022 - 06/2006)
2.	Escobar-Hoyos, Luisa F: 13 articles (01/2022 - 04/2014)
3.	Shroyer, Kenneth R: 13 articles (01/2022 - 04/2014)
4.	Coulombe, Pierre A: 8 articles (01/2021 - 06/2002)
5.	Dang, Erle: 7 articles (01/2022 - 10/2017)
6.	Babu, Sruthi: 7 articles (11/2021 - 01/2019)
7.	Fang, Hui: 6 articles (01/2022 - 10/2017)
8.	Akalin, Ali: 6 articles (11/2021 - 09/2015)
9.	Roa-Peña, Lucia: 5 articles (11/2021 - 09/2015)
10.	Smith, Frances J D: 5 articles (07/2017 - 04/2004)

Related Diseases

1.	Neoplasms (Cancer) 12/01/1993 - "Keratin 17 expression may prove prognostically helpful when assessing dysplasia in epidermal tumors." 12/01/2021 - "Previous studies show that Keratin 17 (KRT17) plays an important role in the development of many malignant tumors. " 01/01/2021 - "Accumulating evidence revealed that keratin 17 (KRT17) is closely related to the prognosis and progression of various tumors including a recent study also implying the potential role of KRT17 in the diagnosis of BCa. " 08/01/2022 - "The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance." 04/28/2022 - "Keratin 17 (KRT17), a member of the intermediate filament family, can regulate tumor cell proliferation and migration. "
2.	Cysts 01/01/2010 - "Immunostaining for cytokeratin 17 and carcinoembryonic antigen showed strongly positive results in the Meibomian gland cysts and, by comparison, negative results in cutaneous epidermal cysts. " 06/01/1997 - "We compared the patterns of keratin 10 (K10) and keratin 17 (K17) expression in epidermoid cysts, trichilemmal cysts, eruptive vellus hair cysts, and steatocystoma multiplex. " 12/01/2003 - "Using intradermal injection of a chimeric RNA-DNA oligonucleotide (RDO) or a single-stranded oligonucleotide (ssODN) into murine skin, we attempted to make a dominant mutation (R94p) in the conserve alpha-helical domain of keratin 17 (K17), the same mutation found in pachyononychia congenichia type 2 (PC-2) patients with phenotypes ranging from twisted hair and multiple pilosebaceous cysts. " 06/01/1998 - "Based on the patterns of keratin 17 mRNA and neural cell adhesion molecule antigen expression, and on the distribution of alkaline phosphatase activity, we propose that dermal cysts in hr skin arise from (i) the central ORS, (ii) bulge-derived cells, or (iii) the disintegrating proximal ORS under the influence of dermal papilla remnants. " 07/01/2019 - "The authors compared the histological and immunohistochemical profile of IKCs and epidermal inclusion cysts by staining sections from each specimen with hematoxylin and eosin, periodic acid-Schiff, Masson trichrome, cytokeratin 5, cytokeratin 17, carcinoembryonic antigen, and epithelial membrane antigen. "
3.	Epidermal Cyst (Sebaceous Cyst) 03/01/2003 - "Mutation in the 1A domain of keratin 17 underlies the affected members' phenotype, PC-2 with early onset sebaceous cysts and late-onset thickened fingernails and toenails. " 03/01/2003 - "Keratin 17 mutation in pachyonychia congenita type 2 with early onset sebaceous cysts." 01/01/2010 - "Immunostaining for cytokeratin 17 and carcinoembryonic antigen showed strongly positive results in the Meibomian gland cysts and, by comparison, negative results in cutaneous epidermal cysts. " 06/01/1997 - "We compared the patterns of keratin 10 (K10) and keratin 17 (K17) expression in epidermoid cysts, trichilemmal cysts, eruptive vellus hair cysts, and steatocystoma multiplex. "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2017 - "The purpose of this study is to explore the how microRNA-138 (miR-138) affects the expression of keratin 17 (K17) and psoriasis development. " 01/01/2022 - "Keratin 17 in psoriasis: Current understanding and future perspectives." 11/20/2020 - "Keratin 17 (K17), a type I intermediate filament, is overexpressed in the psoriatic epidermis and plays a critical pathogenic role by stimulating T cells in psoriasis. " 03/01/2014 - "Keratin 17: a critical player in the pathogenesis of psoriasis." 09/01/2012 - "Keratin 17 as a therapeutic target for the treatment of psoriasis."
5.	Carcinogenesis 01/01/2021 - "Diagnostic Value of Cytokeratin 17 during Oral Carcinogenesis: An Immunohistochemical Study." 01/01/2021 - "Little is known about the role of cytokeratin 17 (CK17) during oral carcinogenesis. " 11/01/2017 - "Keratin 17 (KRT17) was shown to be an important molecular marker for predicting the carcinogenesis, progression, and prognosis of various cancer types. " 11/01/2015 - "Overall, our study demonstrates that genetic loss of caspase-7 promotes SSL-induced skin carcinogenesis by blocking caspase-7-mediated cleavage of keratin-17. " 10/27/2016 - "Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo."

Related Drugs and Biologics

1.	Carcinoembryonic Antigen
2.	Biomarkers (Surrogate Marker)
3.	Keratin-7 (Cytokeratin 7)
4.	Keratin-5 (Keratin 5)
5.	Keratin-20 (Cytokeratin 20)
6.	Oncogene Proteins (Oncogene Protein)
7.	Caspase 7
8.	calcipotriene (calcipotriol)
9.	sodium iodate
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Radiotherapy
2.	Lasers (Laser)
3.	Therapeutics
4.	Optical Fibers
5.	Ligation