Keratin-4 (Keratin 4)

A type II keratin that is found associated with the KERATIN-13 in the internal stratified EPITHELIUM. Defects in gene for keratin-4 are a cause of HEREDITARY MUCOSAL LEUKOKERATOSIS.

Also Known As:

Networked: 31 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yang, Jie: 2 articles (07/2018 - 04/2014)
2.	Kawachi, Hiroshi: 2 articles (03/2012 - 03/2011)
3.	Aragaki, Tadanobu: 2 articles (03/2011 - 12/2010)
4.	Okada, Norihiko: 2 articles (03/2011 - 12/2010)
5.	Sakamoto, Kei: 2 articles (03/2011 - 12/2010)
6.	Yamaguchi, Akira: 2 articles (03/2011 - 12/2010)
7.	Braakhuis, Boudewijn J M: 2 articles (02/2010 - 12/2009)
8.	Brakenhoff, Ruud H: 2 articles (02/2010 - 12/2009)
9.	Heck, Albert J R: 2 articles (02/2010 - 12/2009)
10.	Schaaij-Visser, Tieneke B M: 2 articles (02/2010 - 12/2009)

Related Diseases

1.	Nevus (Nevi) 07/01/2018 - "The aim of this study was to investigate the roles of keratin 4 (KRT4) gene in the development of human white sponge nevus (WSN). " 11/22/2022 - "White Sponge Nevus Caused by Keratin 4 Gene Mutation: A Case Report." 12/01/2019 - "Other entities that can induce large papillomatous lesions that involve the mucous membranes and skin include condyloma acuminatum, which is sexually transmitted, and white sponge nevus, often due to a mutation of cytokeratin 4 or 13. " 07/01/2018 - "Keratin 4 regulates the development of human white sponge nevus." 02/01/2018 - "We describe a novel heterozygous missense mutation in the keratin-4 gene of a Swedish family with white sponge nevus. "
2.	Neoplasms (Cancer) 03/13/2012 - "Reduced expression of cytokeratin 4 and 13 is a valuable marker for histologic grading of esophageal squamous intraepithelial neoplasia." 04/06/2000 - "Interestingly, ELF3 suppressed basal keratin 4 promoter activity in both esophageal and cervical epithelial cancer cell lines, a novel result, while simultaneously activating the late-differentiation linked SPRR2A promoter. " 08/01/1994 - "Cytokeratin 4 was detected in a minor population of tumor cells. " 02/01/2010 - "In a previous study we discovered by a comprehensive proteomics approach that compared to normal mucosa, protein expression of cornulin, keratin 4 and keratin 13 is decreased in tumors and severe dysplasia, preneoplastic tissue with a high risk of malignant progression. " 01/01/2021 - "Keratin 4 (KRT4), ribosomal protein L14 (RPL14), proprotein convertase subtilisin/kexin type 6 (PCSK6), poly(A)-binding protein cytoplasmic 3 (PABPC3), and sterile alpha and TIR motif containing 1 (SARM1) mutations were detected in both peripheral blood and tumor samples. "
3.	Papilloma (Papillomatosis) 05/01/1997 - "Expression of p53, Ki-67 and cytokeratin-4 (CK4) in oral papillomas." 05/01/1997 - "This study was carried out to investigate whether p53 expression was correlated with expression of the cellular proliferation marker Ki-67 and the epithelial differentiation marker cytokeratin-4 (CK4) in oral papillomas. "
4.	Cholesteatoma 12/01/2012 - "Cytokeratin 4 was expressed in basal layer of retroauricular skin, but occasionally expressed in suprabasal layer of cholesteatoma. " 12/01/2012 - "Immunohistochemical study was carried out in 30 cholesteatoma tissues and 10 retroauricular skins to examine the expression of involucrin, filaggrin, cytokeratin 4, 10 and 16. " 12/01/2012 - "Comparative analysis of the expression of involucrin, filaggrin and cytokeratin 4, 10, 16 in cholesteatoma."
5.	Esophageal Squamous Cell Carcinoma 03/01/2011 - "Several studies have suggested that fascin, cytokeratin 14 and cytokeratin 4 may have significant roles as biomarkers for the progression and survival of esophageal squamous cell carcinoma (ESCC). "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Keratin-13 (Keratin 13)
3.	Proteins (Proteins, Gene)
4.	Biomarkers (Surrogate Marker)
5.	Keratin-14 (Keratin 14)
6.	Differentiation Antigens
7.	Filaggrin Proteins
8.	involucrin
9.	fascin
10.	Keratin-17 (Keratin 17)